Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins

Clinical Infectious Diseases

Volumn 10, Issue 4, 1988, Pages 746-751

  Hiraoka, Masaki ^a,b   Inoue, Matsuhisa ^a,b   Mitsuhashi, Susumu ^a,b  

^a Episome Institute   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; BETA LACTAMASES; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CEPHALOSPORINASE; IMIPENEM;

ANTIBIOTIC RESISTANCE; ARTICLE; CELL MEMBRANE PERMEABILITY; CITROBACTER; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HYDROLYSIS; KINETICS; METABOLISM; MOLECULAR CLONING; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEUS VULGARIS;

BETA-LACTAMASES; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CELL MEMBRANE PERMEABILITY; CEPHALOSPORINASE; CEPHALOSPORINS; CITROBACTER; CLONING, MOLECULAR; COMPARATIVE STUDY; DRUG RESISTANCE, MICROBIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HYDROLYSIS; IMIPENEM; KINETICS; MUTATION; PROTEUS VULGARIS;

EID: 0024043725     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/clinids/10.4.746     Document Type: Article

References (31)

1. Seeberg AH, Tolxdorff-Neutzling RM, Wiedemann B. Chromosomal P-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins. An-timicrob Agents Chemother 1983;23:918-25
2. Towner KJ, Massam M. Resistance to P-lactamase-stable cephalosporin antibiotics in strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from blood cultures. J Antimicrob Chemother 1985;16:699-707
3. Curtis NAC, Eisenstadt RL, Rudd C, White AJ. Inducible type 1 P-lactamases of gram-negative bacteria and resistance to P-lactam antibiotics. J Antimicrob Chemother 1986;17:51-61
4. Sanders CC, Sanders WE. Microbial resistance to newer generation (5-lactam antibiotics: Clinical and laboratory im-plications. J Infect Dis 1985;151:399-406
5. Lindberg F, Normark S. Contribution of chromosomal (3lactamases to P-lactam resistance in enterobacteria. Rev Infect Dis 1986;8(Suppl 3):S292-304
6. Then RL, Angehrn P. Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism. Antimicrob Agents Chemother 1982;21:711-7
7. Sanders CC. Novel resistance selected by newer expandedspectrum cephalosporins: A concern. J Infect Dis 1983;147:585-9
8. Piddock LJV, Wise R. Newer mechanisms of resistance to P-lactam antibiotics in gram-negative bacteria. J Antimicrob Chemother 1985;16:279-84
9. Vu H, Nikaido H. Role of p-lactam hydrolysis in the mechanism of resistance of a P-Iactamase-constitutive Enterobacter cloacae strain to expanded-spectrum P-lactams. Antimicrob Agents Chemother 1985;27:393-8
10. Toda M, Sato K, Nakazawa H, Inoue M, Mitsuhashi S. Effect of N-formimidoyl thienamycin (MK0787) on P-lactamases and activity against P-lactamase-producing strains. Antimicrob Agents Chemother 1980;18:837-8
11. Vuye A, Pijck J. In vitro antibacterial activity of BMY-28142, a new extended-spectrum cephalosporin. Antimicrob Agents Chemother 1985;27:574-7
12. Phelps DJ, Carlton DD, Farrell CA, Kessler RE. Affinity of cephalosporins for P-lactamases as a factor in antibacterial efficacy. Antimicrob Agents Chemother 1986;29:845-8
13. Hiraoka M, Masuyoshi S, Mitsuhashi S, Tomastu K, Inoue M. Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime. J An-tibiot (Tokyo) 1988;41:86-93
14. Tajima M, Takenouchi Y, Sugawara S, Inoue M, Mitsuhashi S. Purification and properties of chromosomally mediated P-lactamase from Citrobacter freundii GN7391. J Gen Microbiol 1980;121:449-56
15. Minami S, Inoue M, Mitsuhashi S. Purification and properties of a cephalosporinase from Enterobacter cloacae. Antimicrob Agents Chemother 1980;18:853-7
16. Tajima M, Masuyoshi S, Inoue M, Takenouchi Y, Sugawara S, Mitsuhashi S. Purification and properties of p-lactamases from Serratia marcescens. J Gen Microbiol 1981;126:179-84
17. Murata T, Minami S, Yasuda K, Iyobe S, Inoue M, Mitsuhashi S. Purification and properties of cephalosporinase from Pseudomonas aeruginosa. J Antibiot (Tokyo) 1981; 34:1164-70
18. Minami S, Inoue M, Mitsuhashi S. Purification and properties of cephalosporinase in Escherichia coli. Antimicrob Agents Chemother 1980;18:77-80
19. Matsubara N, Yotsuji A, Kumano K, Inoue M, Mitsuhashi S. Purification and some properties of a cephalosporinase from Proteus vulgaris. Antimicrob Agents Chemother 1981;19:185-7
20. Hirai K, Iyobe S, Inoue M, Mitsuhashi S. Purification and properties of a new P-lactamase from Pseudomonas cepacia. Antimicrob Agents Chemother 1980;17:355-8
21. Saino Y, Kobayashi F, Inoue M, Mitsuhashi S. Purification and properties of inducible penicillin P-lactamase isolated from Pseudomonas maltophilia. Antimicrob Agents Chemother 1982;22:564-70
22. Saino Y, Inoue M, Mitsuhashi S. Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873. Antimicrob Agents Chemother 1984;25:362-5
23. Sato K, Matsuura Y, Miyata K, Inoue M, Mitsuhashi S. Characterization of cephalosporinases from Bacteroidesfragilis, Bacteroides thetaiotaomicron and Bacteroides vulgatus. J Antibiot (Tokyo) 1983;36:76-85
24. Casadaban MJ. Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and mu. J Mol Biol 1976;104:541-55
25. Hall MN, Silhavy TJ. Genetic analysis of the ompB locus in Escherichia coli K-12. J Mol Biol 1981;151:1-15
26. Chang ACY, Cohen SN. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the pl5A cryptic miniplasmid. J Bacteriol 1978;134: 1141-56
27. Maejima T, Ohya Y, Mitsuhashi S, Inoue M. Cloning and expression of the gene(s) for chromosome-mediated p-lactamase production of Proteus vulgaris in Escherichia coli. Plasmid 1987;18:120-6
28. Minami S, Yotsuji A, Inoue M, Mitsuhashi S. Induction of P-lactamase by various P-lactam antibiotics in Enterobacter cloacae. Antimicrob Agents Chemother 1980;18:382-5
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75
30. Yoshimura F, Nikaido H. Diffusion of P-lactam antibiotics through the porin channels of Escherichia coli K-12. Antimicrob Agents Chemother 1985;27:84-92
31. Mitsuyama J, Hiruma R, Yamaguchi A, Sawai T. Identification of porins in outer membrane of Proteus, Morganella, and Providencia spp. and their role in outer membrane permeation of P-lactams. Antimicrob Agents Chemother 1987;31:379-84