Pulse Dosing Versus Continuous Infusion of Antibiotics: Pharmacokinetic-Pharmacodynamic Considerations

Clinical Pharmacokinetics

Volumn 14, Issue 2, 1988, Pages 71-95

  LeBel, Marc ^a,b,c,d   Spino, Michael ^a,b,c  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

HUMAN; INTRAVENOUS DRUG ADMINISTRATION; REVIEW;

ANTIBIOTICS; HUMAN; INFUSIONS, INTRAVENOUS;

EID: 0023957592     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/00003088-198814020-00002     Document Type: Review

References (73)

1. The influence of route of administration on wound fluid concentration of prophylactic antibiotics
2. A comparative experimental study of the circulation of amoxycillin and penicillin G in the cerebrospinal fluid of dogs as a function of the type of intravenous administration
3. Efficacy of continuous versus intermittent administration of penicillin G in Streptococcus pneumoniae pneumonia in normal and immunodeficient rats
4. Pharmacokinetics of antibiotics
5. General principles of antibiotic tissue penetration
6. Comparison of the effects of continuous and intermittent systemic administration on the penetration of gentamicin into infected rabbit eyes
7. Pharmacokinetics of tissue penetration of antibiotics
8. Influence of constant infusion versus bolus injections of antibiotics
9. Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model
10. A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients
11. The role of schedule in antibiotic therapy of the neutropenic patient
12. Cefoperazone for the treatment of infections in patients with cancer
13. High-dose penicillin therapy and pneumococcal pneumonia
14. Serum bactericidal rate as measure of antibiotic interactions
15. The etiology and persistence of cryptic bacterial infections: a hypothesis
16. The postantibiotic effect
17. Choice of drug and dosage regimen: two important risk factors for aminoglycoside nephrotoxicity
18. Integration of selected pharmacologic and microbiologic properties of three new beta-lactam antibiotics: a hypothesis for comparison
19. Experimental approach to the problem of treatment failure with penicillin
20. ‘Continuous’ vs ‘discontinuous’ therapy with penicillin: the effect of the interval between injections on therapeutic efficacy
21. Effect of schedule of administration on the therapeutic efficacy of penicillin
22. The effect of the method of administration on the therapeutic efficacy of sodium penicillin in experimental syphilis
23. Kinetics of cephaloridine in experimental wounds
24. The inhibitory quotient: a method for interpreting minimum inhibitory concentration data
25. A comparative trial of sisomicin therapy by intermittent versus continuous infusion
26. Effect of dose on pharmacokinetics and serum bactericidal activity of mezlocillin
27. Multiple dose pharmacokinetics of ceftazidime in cancer patients
28. Antibiotic therapy of infection due to Pseudomonas aeruginosa in normal and granulocytopenic mice: comparison of murine and human pharmacokinetics
29. Impact of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice
30. Constant infusions vs intermittent doses of gentamicin against Pseudomonas aeruginosa in vitro
31. Penetration of penicillin into foci of infection
32. Pharmacokinetics and nephrotoxicity of continuous intravenous infusion of gentamicin in low birth weight infants
33. Penetration of tobramycin into infected extravascular fluids and its therapeutic effectiveness
34. Novel approaches for the use of aminoglycosides: the value of experimental models
35. Theory and application of pulse dosing: a summary of the symposium
36. Comparative studies of intermittent and continuous administration of aminoglycosides in the treatment of bronchopulmonary infections due to Gram-negative bacteria
37. Bacterial elimination and therapeutic effectiveness under different schedules of amoxicillin administration
38. Gentamicin intravenous infusion rate: effect on interstitial fluid concentration
39. Antimicrobial combinations
40. Influence of the route of administration on the pharmacokinetics of amikacin
41. Influence of four modes of administration on penetration of aztreonam, cefuroxime, and ampicillin into interstitial fluid and fibrin clots and on in vivo efficacy against Haemophilis influenzae
42. Difference in blister fluid penetration after single and multiple doses of ceftriaxone
43. Low concentrations of antibiotics
44. Postantibiotic leukocyte enhancement: increased susceptibility of bacteria pretreated with antibiotics to activity of leukocytes
45. Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model
46. Comparative efficacy of cefotiam, cefmenoxime, and ceftriaxone in experimental endocarditis and correlation with pharmacokinetics and in vitro efficacy
47. Efficacy of different dosing schedules of tobramycin for treating a murine Klebsiella pneumoniae bronchopneumonia
48. Effects of method of antibiotic administration on extravascular penetration: crossover study of cefazolin given by intermittent injection or constant infusion
49. Studies on the pathogenesis of meningitis: IV. Penicillin levels in the cerebrospinal fluid in experimental meningitis
50. Once-daily vs continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin
51. Influence of dosage interval on the therapeutic response to gentamicin in mice infected with Klebsiella pneumoniae
52. Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in an experimental Klebsiella pneumoniae pneumonia in rats
53. Continuous versus intermittent administration of ceftazidime in experimental Klebsiella pneumoniae pneumonia in normal and leukopenic rats
54. Intermittent or continuous therapy of experimental meningitis due to Streptococcus pneumoniae in rabbits: preliminary observations on the post-antibiotic effect in vivo
55. Dual individualization with antibiotics
56. The influence of the dosage regimen on the therapeutic effectiveness of penicillin G in experimental lobar pneumonia
57. The influence of the dosage regimen on the therapeutic activity of penicillin G
58. Pharmacokinetic and microbiologic evaluation of dosage regimens of newer cephalosporins and penicillins
59. Continuous-infusion ampicillin therapy of enterococcal endocarditis in rats
60. Pharmacological study of cefazolin during intermittent and continuous infusion: a crossover investigation in humans
61. Effect of method of administration on extravascular penetration of four antibiotics
62. Effect of the ratio of surface area to volume on the penetration of antibiotics into extravascular spaces in an in vitro model
63. Kinetics of antimicrobial activity
64. Serum bactericidal activity as a monitor of antibiotic therapy
65. Netilmicin in the treatment of infections in patients with cancer
66. Non-linear saturable pharmacodynamic modelling of piperacillin versus Pseudomonas aeruginosa