메뉴 건너뛰기




Volumn 48, Issue 11, 1986, Pages 2946-2954

Roles of Cytochrome P-450 Enzymes in Chemical Carcinogenesis and Cancer Chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

EID: 0023951396     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (525)

References (132)
  • 1
    • 0001315679 scopus 로고
    • The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates
    • Mueller, G. C., and Miller, J. A. The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates. J. Biol. Chem., 176:535-544, 1948.
    • (1948) J. Biol. Chem. , vol.176 , pp. 535-544
    • Mueller, G.C.1    Miller, J.A.2
  • 2
    • 0001477544 scopus 로고
    • The metabolism of methylated aminoazo dyes. II. Oxidative demethylation by rat liver homogenates
    • Mueller, G. C., and Miller, J. A. The metabolism of methylated aminoazo dyes. II. Oxidative demethylation by rat liver homogenates. J. Biol. Chem., 202:579-587,1953.
    • (1953) J. Biol. Chem , vol.202 , pp. 579-587
    • Mueller, G.C.1    Miller, J.A.2
  • 3
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
    • Omura, T., and Sato, R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239: 2370-2378,1964.
    • (1964) J. Biol. Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 4
    • 0001426302 scopus 로고
    • Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems
    • Cooper, D. Y., Levine, S., Narasimhulu, S., Rosenthal, O., and Estabrook, R. W. Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems. Science (Wash. DC), 147:400-402, 1965.
    • (1965) Science (Wash. DC) , vol.147 , pp. 400-402
    • Cooper, D.Y.1    Levine, S.2    Narasimhulu, S.3    Rosenthal, O.4    Estabrook, R.W.5
  • 5
    • 0004933142 scopus 로고
    • The metabolism of methylated amino azo dyes. IV. Dietary factors enhancing demethylation in vitro
    • Brown, R. R., Miller, J. A., and Miller, E. C. The metabolism of methylated amino azo dyes. IV. Dietary factors enhancing demethylation in vitro. J. Biol. Chem., 209:211-222,1954.
    • (1954) J. Biol. Chem , vol.209 , pp. 211-222
    • Brown, R.R.1    Miller, J.A.2    Miller, E.C.3
  • 6
    • 84930288145 scopus 로고
    • The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methykholanthrene
    • Conney, A. H., Miller, E. C., and Miller, J. A. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methykholanthrene. Cancer Res., 16:450-459,1956.
    • (1956) Cancer Res , vol.16 , pp. 450-459
    • Conney, A.H.1    Miller, E.C.2    Miller, J.A.3
  • 7
    • 34250951164 scopus 로고
    • The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates
    • Remmer, H. The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol., 237:296-307, 1957.
    • (1957) Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. , vol.237 , pp. 296-307
    • Remmer, H.1
  • 8
    • 0014008942 scopus 로고
    • Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene-treated rats
    • Sladek, N. E., and Mannering, G. J. Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene-treated rats. Biochem. Biophys. Res. Commun., 24:668-674,1966.
    • (1966) Biochem. Biophys. Res. Commun. , vol.24 , pp. 668-674
    • Sladek, N.E.1    Mannering, G.J.2
  • 9
    • 0001418147 scopus 로고
    • Studies in the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene
    • Alvares, A. P., Schilling, G., Levin, W., and Kuntzman, R. Studies in the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene. Biochem. Biophys. Res. Commun., 29: 521–526, 1967.
    • (1967) Biochem. Biophys. Res. Commun. , vol.29 , pp. 521-526
    • Alvares, A.P.1    Schilling, G.2    Levin, W.3    Kuntzman, R.4
  • 10
    • 0001786847 scopus 로고
    • Enzymology of rat liver cytochromes P-450
    • F. P. Guengerich (ed.) Boca Raton, FL: CRC Press
    • Guengerich, F. P. Enzymology of rat liver cytochromes P-450. In: F. P. Guengerich (ed.), Mammalian Cytochromes P-450, Vol. 1, pp. 1–54. Boca Raton, FL: CRC Press, 1987.
    • (1987) Mammalian Cytochromes P-450 , vol.1 , pp. 1-54
    • Guengerich, F.P.1
  • 11
    • 0001786847 scopus 로고
    • Enzymology of human liver cytochromes P-450
    • F. P. Guengerich (ed.) Boca Raton, FL: CRC Press
    • Distlerath, L. M., and Guengerich, F. P. Enzymology of human liver cytochromes P-450. In: F. P. Guengerich (ed.), Mammalian Cytochromes P-450, Vol. 1, pp. 133–198. Boca Raton, FL: CRC Press, 1987.
    • (1987) Mammalian Cytochromes P-450 , vol.1 , pp. 133-198
    • Distlerath, L.M.1    Guengerich, F.P.2
  • 12
    • 0001786846 scopus 로고
    • Cytochrome P-450 enzymes and drug metabolism
    • J. Bridges, L. F. Chasseaud, and G. G. Gibson (eds.) Chap. 1 London: Taylor and Francis
    • Guengerich, F. P. Cytochrome P-450 enzymes and drug metabolism. In: J. Bridges, L. F. Chasseaud, and G. G. Gibson (eds.), Progress in Drug Metabolism, Vol. 10, Chap. 1, pp. 1–54. London: Taylor and Francis, 1987.
    • (1987) Progress in Drug Metabolism , vol.10 , pp. 1-54
    • Guengerich, F.P.1
  • 16
    • 0022555426 scopus 로고
    • The regulation of cytochrome P-450 gene expression
    • Whitlock, J. P., Jr. The regulation of cytochrome P-450 gene expression. Annu. Rev. Pharmacol. Toxicol., 26:333-369,1986.
    • (1986) Annu. Rev. Pharmacol. Toxicol. , vol.26 , pp. 333-369
    • Whitlock, J.P.1
  • 18
    • 0023061373 scopus 로고
    • P-450 genes: structure, evolution, and regulation
    • Nebert, D. W., and Gonzalez, F. J. P-450 genes: structure, evolution, and regulation. Annu. Rev. Biochem., 56:945-993,1987.
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 945-993
    • Nebert, D.W.1    Gonzalez, F.J.2
  • 19
    • 0002844452 scopus 로고
    • Role of cytochrome P-450 in metabolism of chemical carcinogens
    • F. P. Guengerich (ed.) Boca Raton, FL: CRC Press
    • Kadlubar, F. F., and Hammons, G. J. Role of cytochrome P-450 in metabolism of chemical carcinogens. In: F. P. Guengerich (ed.), Mammalian Cytochromes P-450, Vol. 2, pp. 81–130. Boca Raton, FL: CRC Press, 1987.
    • (1987) Mammalian Cytochromes P-450 , vol.2 , pp. 81-130
    • Kadlubar, F.F.1    Hammons, G.J.2
  • 20
    • 84965838091 scopus 로고
    • ed Ed. 2. ACS Monograph 182 and 2. Washington, DC: American Chemical Society
    • Searle, C. E. (ed.). Chemical Carcinogens, Ed. 2. ACS Monograph 182, Vols. 1 and 2. Washington, DC: American Chemical Society, 1984.
    • (1984) Chemical Carcinogens , vol.1
    • Searle, C.E.1
  • 21
    • 0018081539 scopus 로고
    • Genetic control of carcinogen metabolism leading to individual differences in cancer risk
    • Nebert, D. W. Genetic control of carcinogen metabolism leading to individual differences in cancer risk. Biochimie (Paris), 60:1019-1029,1978.
    • (1978) Biochimie (Paris) , vol.60 , pp. 1019-1029
    • Nebert, D.W.1
  • 23
    • 0019258573 scopus 로고
    • Metabolism and activation of chemical carcinogens
    • Weisburger, E. K. Metabolism and activation of chemical carcinogens. Mol. Cell. Biochem., 32:95-104, 1980.
    • (1980) Mol. Cell. Biochem. , vol.32 , pp. 95-104
    • Weisburger, E.K.1
  • 24
    • 0018902496 scopus 로고
    • The role of metabolism in chemical mutagenesis and chemical carcinogenesis
    • Wright, A. S. The role of metabolism in chemical mutagenesis and chemical carcinogenesis. Mutat. Res., 75: 215–241, 1980.
    • (1980) Mutat. Res , vol.75 , pp. 215-241
    • Wright, A.S.1
  • 25
    • 0019841317 scopus 로고
    • Chemical carcinogenesis
    • Farber, E. Chemical carcinogenesis. N. Engl. J. Med., 305: 1379–1389, 1981.
    • (1981) N. Engl. J. Med. , vol.305 , pp. 1379-1389
    • Farber, E.1
  • 26
    • 0019519171 scopus 로고
    • Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules
    • Miller, E. C., and Miller, J. A. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer (Phila.), 47:2327-2345, 1981.
    • (1981) Cancer (Phila.) , vol.47 , pp. 2327-2345
    • Miller, E.C.1    Miller, J.A.2
  • 27
    • 0019789803 scopus 로고
    • Current concepts and controversies in chemical carcinogenesis
    • Weinstein, I. B. Current concepts and controversies in chemical carcinogenesis. J. Supramol. Struct. Cell. Biochem., 17:99-120, 1981.
    • (1981) J. Supramol. Struct. Cell. Biochem. , vol.17 , pp. 99-120
    • Weinstein, I.B.1
  • 28
    • 0020431144 scopus 로고
    • Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture
    • Conney, A. H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res., 42:4875-4917,1982.
    • (1982) Cancer Res , vol.42 , pp. 4875-4917
    • Conney, A.H.1
  • 29
    • 0000736193 scopus 로고
    • Metabolism of chemical carcinogens
    • F. F. Becker (ed.) Ed. 2 New York: Plenum Publishing Corp
    • Weisburger, J. H., and Williams, G. M. Metabolism of chemical carcinogens. In: F. F. Becker (ed.), Cancer A Comprehensive Treatise, Vol. 1, Ed. 2, pp. 241–333. New York: Plenum Publishing Corp., 1982.
    • (1982) Cancer A Comprehensive Treatise , vol.1 , pp. 241-333
    • Weisburger, J.H.1    Williams, G.M.2
  • 31
    • 0022566931 scopus 로고
    • Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates
    • Kato, R. Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates. CRC Crit. Rev. Toxicol., 16:307-348, 1986.
    • (1986) CRC Crit. Rev. Toxicol. , vol.16 , pp. 307-348
    • Kato, R.1
  • 32
    • 0003770688 scopus 로고
    • Enzymology of rabbit cytochromes P-450
    • F. P. Guengerich (ed.) Boca Raton, FL: CRC Press
    • Schwab, G. E., and Johnson, E. F. Enzymology of rabbit cytochromes P-450. In: F. P. Guengerich (ed.), Mammalian Cytochromes P-450, Vol. 1, pp. 55–105, Boca Raton, FL: CRC Press, 1987.
    • (1987) Mammalian Cytochromes P-450 , vol.1 , pp. 55-105
    • Schwab, G.E.1    Johnson, E.F.2
  • 33
    • 0023276802 scopus 로고
    • Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK 1002
    • Shimada, T., and Nakamura, S.-I. Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK 1002. Biochem. Pharmacol., 36:1979-1987,1987.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 1979-1987
    • Shimada, T.1    Nakamura, S.-I.2
  • 34
    • 0017409770 scopus 로고
    • Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest
    • Guengerich, F. P. Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest. J. Biol. Chem., 252: 3970-3979,1977.
    • (1977) J. Biol. Chem , vol.252 , pp. 3970-3979
    • Guengerich, F.P.1
  • 38
    • 77957185551 scopus 로고
    • Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver
    • Kawano, S., Kamataki, T., Maeda, K., Kato, R., Nakao, T., and Mizoguchi, I. Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver. Fundam. Appl. Toxicol., 5: 487-498,1985.
    • (1985) Fundam. Appl. Toxicol. , vol.5 , pp. 487-498
    • Kawano, S.1    Kamataki, T.2    Maeda, K.3    Kato, R.4    Nakao, T.5    Mizoguchi, I.6
  • 39
    • 0343614616 scopus 로고
    • Oxidation of carcinogenic aryl amines by cytochrome P-450 enzymes
    • C. M. King, L. J. Romano, and D. Schuetzle (eds.) New York: Elsevier Scientific Publishing Co., Inc
    • Guengerich, F. P., Butler, M. A., Macdonald, T. L., and Kadlubar, F. F. Oxidation of carcinogenic aryl amines by cytochrome P-450 enzymes. In: C. M. King, L. J. Romano, and D. Schuetzle (eds.), Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp. 89–95. New York: Elsevier Scientific Publishing Co., Inc., 1987.
    • (1987) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes , pp. 89-95
    • Guengerich, F.P.1    Butler, M.A.2    Macdonald, T.L.3    Kadlubar, F.F.4
  • 40
    • 0019990422 scopus 로고
    • Cytochrome P-450 and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene, and its covalent binding to nuclear DNA
    • Frederick, C. B., Mays, J. B., Ziegler, D. M., Guengerich, F. P., and Kadlubar, F. F. Cytochrome P-450 and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene, and its covalent binding to nuclear DNA. Cancer Res., 42:2671-2677,1982.
    • (1982) Cancer Res. , vol.42 , pp. 2671-2677
    • Frederick, C.B.1    Mays, J.B.2    Ziegler, D.M.3    Guengerich, F.P.4    Kadlubar, F.F.5
  • 41
    • 0022006601 scopus 로고
    • Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases
    • Hammons, G. J., Guengerich, F. P., Weis, C. C., Beland, F. A., and Kadlubar, F. F. Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases. Cancer Res., 45:3578-3585, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 3578-3585
    • Hammons, G.J.1    Guengerich, F.P.2    Weis, C.C.3    Beland, F.A.4    Kadlubar, F.F.5
  • 42
    • 0017093791 scopus 로고
    • Metabolism of benzo(a)pyrene and benzo(a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes
    • Wood, A. W., Levin, W., Lu, A. Y. H., Yagi, H., Hernandez, O., Jerina, D. M., and Conney, A. H. Metabolism of benzo(a)pyrene and benzo(a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. J. Biol. Chem., 251:4882-4890, 1976.
    • (1976) J. Biol. Chem. , vol.251 , pp. 4882-4890
    • Wood, A.W.1    Levin, W.2    Lu, A.Y.H.3    Yagi, H.4    Hernandez, O.5    Jerina, D.M.6    Conney, A.H.7
  • 45
    • 0021166751 scopus 로고
    • Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo(a)pyrene
    • Yamazoe, Y., Shimada, M., Maeda, K., Kamataki, T., and Kato, R. Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo(a)pyrene. Xenobiotica, 14: 549–552, 1984.
    • (1984) Xenobiotica , vol.14 , pp. 549-552
    • Yamazoe, Y.1    Shimada, M.2    Maeda, K.3    Kamataki, T.4    Kato, R.5
  • 46
    • 0022360383 scopus 로고
    • Comparative study on the metabolism of N-methyl-4-aminoazobenzene by two forms of cytochrome P-448
    • Kimura, T., Kodama, M., Nagata, C., Kamataki, T., and Kato, R. Comparative study on the metabolism of N-methyl-4-aminoazobenzene by two forms of cytochrome P-448. Biochem. Pharmacol., 34:3375-3377, 1985.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3375-3377
    • Kimura, T.1    Kodama, M.2    Nagata, C.3    Kamataki, T.4    Kato, R.5
  • 47
    • 0022344604 scopus 로고
    • Participation of a rat liver cytochrome P-450 induced by pregnenolone 16a-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin
    • Shimada, T., and Guengerich, F. P. Participation of a rat liver cytochrome P-450 induced by pregnenolone 16a-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin. Mol. Pharmacol., 28:215-219,1985.
    • (1985) Mol. Pharmacol. , vol.28 , pp. 215-219
    • Shimada, T.1    Guengerich, F.P.2
  • 48
    • 0022916021 scopus 로고
    • Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes
    • Beaune, P., Kremers, P. G., Kaminsky, L. S., De Graeve, J., and Guengerich, F. P. Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes. Drug Metab. Dispos., 74:437-442, 1986.
    • (1986) Drug Metab. Dispos. , vol.74 , pp. 437-442
    • Beaune, P.1    Kremers, P.G.2    Kaminsky, L.S.3    De Graeve, J.4    Guengerich, F.P.5
  • 49
    • 0020528873 scopus 로고
    • Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes
    • Kaminsky, L. S., Guengerich, F. P., Dannan, G. A., and Aust, S. D. Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes. Arch. Biochem. Biophys., 225: 398-404,1983.
    • (1983) Arch. Biochem. Biophys. , vol.225 , pp. 398-404
    • Kaminsky, L.S.1    Guengerich, F.P.2    Dannan, G.A.3    Aust, S.D.4
  • 50
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • Guengerich, F. P., Martin, M. W., Beaune, P. H., Kremers, P., Wolff, T., and Waxman, D. J. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem., 261: 5051-5060,1986.
    • (1986) J. Biol. Chem. , vol.261 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.W.2    Beaune, P.H.3    Kremers, P.4    Wolff, T.5    Waxman, D.J.6
  • 51
    • 0021823707 scopus 로고
    • Cytochrome P-450 isozyme/ isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin
    • Kaminsky, L. S., and Guengerich, F. P. Cytochrome P-450 isozyme/ isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. Eur. J. Biochem., 149:479-489,1985.
    • (1985) Eur. J. Biochem. , vol.149 , pp. 479-489
    • Kaminsky, L.S.1    Guengerich, F.P.2
  • 52
    • 0022847113 scopus 로고
    • Expression of bovine 17a-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells
    • Zuber, M. X., Simpson, E. R., and Waterman, M. R. Expression of bovine 17a-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Science (Wash. DC), 234:1258-1261,1986.
    • (1986) Science (Wash. DC) , vol.234 , pp. 1258-1261
    • Zuber, M.X.1    Simpson, E.R.2    Waterman, M.R.3
  • 53
    • 0023136337 scopus 로고
    • Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes
    • Hall, S. D., Guengerich, F. P., Branch, R. A., and Wilkinson, G. R. Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. J. Pharmacol. Exp. Ther., 240:216-222,1987.
    • (1987) J. Pharmacol. Exp. Ther. , vol.240 , pp. 216-222
    • Hall, S.D.1    Guengerich, F.P.2    Branch, R.A.3    Wilkinson, G.R.4
  • 54
    • 0020533983 scopus 로고
    • Suicidal destruction of cytochrome P-450 during oxidative drug metabolism
    • Ortiz de Montellano, P. R., and Correia, M. A. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism. Annu. Rev. Pharmacol. Toxicol., 23:481-503,1983.
    • (1983) Annu. Rev. Pharmacol. Toxicol. , vol.23 , pp. 481-503
    • Ortiz de Montellano, P.R.1    Correia, M.A.2
  • 55
    • 0020288436 scopus 로고
    • Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies
    • Fujino, T., Park, S. S., West, D., and Gelboin, H. V. Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies. Proc. Natl. Acad. Sci. USA, 79:3682-3686, 1982.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3682-3686
    • Fujino, T.1    Park, S.S.2    West, D.3    Gelboin, H.V.4
  • 56
    • 0022263133 scopus 로고
    • Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin 0-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism
    • Distlerath, L. M., Reilly, P. E. B., Martin, M. V., Davis, G. G., Wilkinson, G. R., and Guengerich, F. P. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin 0-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem., 260:9057-9067,1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 9057-9067
    • Distlerath, L.M.1    Reilly, P.E.B.2    Martin, M.V.3    Davis, G.G.4    Wilkinson, G.R.5    Guengerich, F.P.6
  • 57
    • 0021279379 scopus 로고
    • Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450)
    • Kaminsky, L. S., Dannan, G. A., and Guengerich, F. P. Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450). Eur. J. Biochem., 747:141-148,1984.
    • (1984) Eur. J. Biochem. , vol.747 , pp. 141-148
    • Kaminsky, L.S.1    Dannan, G.A.2    Guengerich, F.P.3
  • 58
    • 0017671864 scopus 로고
    • Preparation and properties of highly-purified cytochrome P-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits
    • Guengerich, F. P. Preparation and properties of highly-purified cytochrome P-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits. Mol. Pharmacol., 13:911-923,1977.
    • (1977) Mol. Pharmacol. , vol.13 , pp. 911-923
    • Guengerich, F.P.1
  • 59
    • 0018265604 scopus 로고
    • Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats
    • Guengerich, F. P. Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats. J. Biol. Chem., 253:7931-7939,1978.
    • (1978) J. Biol. Chem , vol.253 , pp. 7931-7939
    • Guengerich, F.P.1
  • 60
    • 0023121619 scopus 로고
    • Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase
    • Umbenhauer, D. R., Martin, M. V., Lloyd, R. S., and Guengerich, F. P. Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. Biochemistry, 26:1094-1099,1987.
    • (1987) Biochemistry , vol.26 , pp. 1094-1099
    • Umbenhauer, D.R.1    Martin, M.V.2    Lloyd, R.S.3    Guengerich, F.P.4
  • 61
    • 0018743832 scopus 로고
    • Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro
    • Levitt, R. C., Pelkonen, O., Okey, A. B., and Nebert, D. W. Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro. J. Natl. Cancer Inst., 62:947-955,1979.
    • (1979) J. Natl. Cancer Inst , vol.62 , pp. 947-955
    • Levitt, R.C.1    Pelkonen, O.2    Okey, A.B.3    Nebert, D.W.4
  • 62
    • 0039327850 scopus 로고
    • The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk for cancer
    • P. O. P. Ts'o and H. V. Gelboin (eds.) New York: Academic Press
    • Nebert, D. W., Atlas, S. A., Guenthner, T. M., and Kouri, R. E. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk for cancer. In: P. O. P. Ts'o and H. V. Gelboin (eds.), Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment, Vol. 2, pp. 345–390. New York: Academic Press, 1978.
    • (1978) Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment , vol.2 , pp. 345-390
    • Nebert, D.W.1    Atlas, S.A.2    Guenthner, T.M.3    Kouri, R.E.4
  • 63
    • 0018616373 scopus 로고
    • The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice
    • Levitt, R. C., Fysh, J. M., Jensen, N. M., and Nebert, D. W. The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice. Genetics, 92:1205-1210,1979.
    • (1979) Genetics , vol.92 , pp. 1205-1210
    • Levitt, R.C.1    Fysh, J.M.2    Jensen, N.M.3    Nebert, D.W.4
  • 64
    • 0019732935 scopus 로고
    • Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia
    • Nebert, D. W. Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia. Environ. Health Perspect., 39:11-22,1981.
    • (1981) Environ. Health Perspect. , vol.39 , pp. 11-22
    • Nebert, D.W.1
  • 65
    • 0018072908 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin: cocarcinogen which enhances 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically “nonresponsive” at Ah locus
    • Kouri, R. E., Rude, T. H., Joglekar, R., Dansette, P. M., Jerina, D. M., Atlas, S. A., Owens, I. S., and Nebert, D. W. 2,3,7,8-Tetrachlorodibenzo-p-dioxin: cocarcinogen which enhances 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically “nonresponsive” at Ah locus. Cancer Res., 38:2777-2783,1978.
    • (1978) Cancer Res. , vol.38 , pp. 2777-2783
    • Kouri, R.E.1    Rude, T.H.2    Joglekar, R.3    Dansette, P.M.4    Jerina, D.M.5    Atlas, S.A.6    Owens, I.S.7    Nebert, D.W.8
  • 66
    • 84965831406 scopus 로고
    • Tumour production by TCDD in skin of HRS/J hairless mice
    • Poland, A., Palen, D., and Glover, E. Tumour production by TCDD in skin of HRS/J hairless mice. Nature (Lond.), 300:217-273,1982.
    • (1982) Nature (Lond.) , vol.300 , pp. 217-273
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 67
    • 0015074909 scopus 로고
    • Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone
    • McLean, A. E. M., and Marshall, A. Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone. Br. J. Exp. Pathol., 52: 322–329, 1971.
    • (1971) Br. J. Exp. Pathol. , vol.52 , pp. 322-329
    • McLean, A.E.M.1    Marshall, A.2
  • 69
    • 84984119449 scopus 로고
    • Studies on ear duct tumors in rats. Part II: Inhibitory effects of methylcholanthrene and 1,2-benzanthracene on tumor formation by 4-dimethylaminostilbene
    • Tawfic, H. N. Studies on ear duct tumors in rats. Part II: Inhibitory effects of methylcholanthrene and 1,2-benzanthracene on tumor formation by 4-dimethylaminostilbene. Acta Pathol. Jpn., 15:255-260,1965.
    • (1965) Acta Pathol. Jpn , vol.15 , pp. 255-260
    • Tawfic, H.N.1
  • 70
    • 0014452109 scopus 로고
    • The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis
    • Kunz, W., Schande, G., and Thomas, C. The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis. Z. Krebsforsch., 72:291-304,1969.
    • (1969) Z. Krebsforsch. , vol.72 , pp. 291-304
    • Kunz, W.1    Schande, G.2    Thomas, C.3
  • 71
    • 0018604170 scopus 로고
    • Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice
    • Uchida, E., and Hirono, I. Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice. Gann, 70:639-644, 1979.
    • (1979) Gann , vol.70 , pp. 639-644
    • Uchida, E.1    Hirono, I.2
  • 72
    • 0001400418 scopus 로고
    • Liver tumor inhibition and adrenal histologic responses in rats to which 3'-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered
    • Richardson, H. L., Stier, A. R., and Borsos-Nachtnebel, E. Liver tumor inhibition and adrenal histologic responses in rats to which 3'-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered. Cancer Res., 12:356-361,1952.
    • (1952) Cancer Res. , vol.12 , pp. 356-361
    • Richardson, H.L.1    Stier, A.R.2    Borsos-Nachtnebel, E.3
  • 73
    • 84961026584 scopus 로고
    • On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene
    • Miller, E. C., Miller, J. A., Brown, R. R., and MacDonald, J. C. On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene. Cancer Res., 18: 469-477,1958.
    • (1958) Cancer Res. , vol.18 , pp. 469-477
    • Miller, E.C.1    Miller, J.A.2    Brown, R.R.3    MacDonald, J.C.4
  • 74
    • 0020326790 scopus 로고
    • Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
    • Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257: 7847–7851, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 7847-7851
    • Castagna, M.1    Takai, Y.2    Kaibuchi, K.3    Sano, K.4    Kikkawa, U.5    Nishizuka, Y.6
  • 75
    • 0020001470 scopus 로고
    • Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenic process and by the initation-promotion regimen
    • Verma, A. K., Conrad, E. A., and Boutwell, R. K. Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenic process and by the initation-promotion regimen. Cancer Res., 42:3519-3525, 1982.
    • (1982) Cancer Res. , vol.42 , pp. 3519-3525
    • Verma, A.K.1    Conrad, E.A.2    Boutwell, R.K.3
  • 76
    • 0020571874 scopus 로고
    • Inhibition of 7-bromoethylbenz(a)anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone
    • Verma, A. K., Garcia, C. T., Ashendel, C. L., and Boutwell, R. K. Inhibition of 7-bromoethylbenz(a)anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone. Cancer Res., 43:3045-3049,1983.
    • (1983) Cancer Res. , vol.43 , pp. 3045-3049
    • Verma, A.K.1    Garcia, C.T.2    Ashendel, C.L.3    Boutwell, R.K.4
  • 77
    • 0020548941 scopus 로고
    • Evidence for a new model of tumor progression from carcinogenesis and tumor promotion studies with 7-bromoethylbenz(a)anthracene
    • Scribner, J. D., Scribner, N. K., McKnight, B., and Mottet, N. K. Evidence for a new model of tumor progression from carcinogenesis and tumor promotion studies with 7-bromoethylbenz(a)anthracene. Cancer Res., 43: 2034-2041,1983.
    • (1983) Cancer Res. , vol.43 , pp. 2034-2041
    • Scribner, J.D.1    Scribner, N.K.2    McKnight, B.3    Mottet, N.K.4
  • 78
    • 0023224579 scopus 로고
    • Inhibition by pentachlorophenol of the initiating and promoting activities of l'-hydrox-ysafrole for the formation of enzyme-altered foci and tumors in rat liver
    • Boberg, E. W., Liem, A., Miller, E. C., and Miller, J. A. Inhibition by pentachlorophenol of the initiating and promoting activities of l'-hydrox-ysafrole for the formation of enzyme-altered foci and tumors in rat liver. Carcinogenesis (Lond.), 8:531-539,1987.
    • (1987) Carcinogenesis (Lond.) , vol.8 , pp. 531-539
    • Boberg, E.W.1    Liem, A.2    Miller, E.C.3    Miller, J.A.4
  • 79
    • 0015623197 scopus 로고
    • Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes
    • Kellermann, G., Luyten-Kellermann, M., and Shaw, C. R. Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am. J. Hum. Genet., 25:327-331,1973.
    • (1973) Am. J. Hum. Genet. , vol.25 , pp. 327-331
    • Kellermann, G.1    Luyten-Kellermann, M.2    Shaw, C.R.3
  • 80
    • 0015682899 scopus 로고
    • Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma
    • Kellermann, G., Shaw, C. R., and Luyten-Kellermann, M. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N. Engl. J. Med., 298:934-937,1973.
    • (1973) N. Engl. J. Med. , vol.298 , pp. 934-937
    • Kellermann, G.1    Shaw, C.R.2    Luyten-Kellermann, M.3
  • 82
    • 0020385021 scopus 로고
    • Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopre-served lymphocytes
    • Kouri, R. E., McKinney, C. E., Slomiany, D. J., Snodgress, D. R., Wray, N. P., and McLemore, T. L. Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopre-served lymphocytes. Cancer Res., 42:5030-5037,1982.
    • (1982) Cancer Res. , vol.42 , pp. 5030-5037
    • Kouri, R.E.1    McKinney, C.E.2    Slomiany, D.J.3    Snodgress, D.R.4    Wray, N.P.5    McLemore, T.L.6
  • 83
    • 0022432242 scopus 로고
    • 1-450 gene sequence and correlation of mRNA with genetic differences in benzo-(a)pyrene metabolism
    • 1-450 gene sequence and correlation of mRNA with genetic differences in benzo-(a)pyrene metabolism. Nucl. Acids Res., 13:4503-4520,1985.
    • (1985) Nucl. Acids Res. , vol.13 , pp. 4503-4520
    • Jaiswal, A.K.1    Gonzalez, F.J.2    Nebert, D.W.3
  • 84
    • 0023217811 scopus 로고
    • Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls
    • Karki, N. T., Pokela, R., Nuutinen, L., and Pelkonen, O. Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls. Int. J. Cancer, 39:565-570,1987.
    • (1987) Int. J. Cancer , vol.39 , pp. 565-570
    • Karki, N.T.1    Pokela, R.2    Nuutinen, L.3    Pelkonen, O.4
  • 86
    • 0019380168 scopus 로고
    • Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer
    • Idle, J. R., Mahgoub, A., Sloan, T. P., Smith, R. L., Mbanefo, C. O., and Bababunmi, E. A. Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer. Cancer Lett., 11:331-338,1981.
    • (1981) Cancer Lett. , vol.11 , pp. 331-338
    • Idle, J.R.1    Mahgoub, A.2    Sloan, T.P.3    Smith, R.L.4    Mbanefo, C.O.5    Bababunmi, E.A.6
  • 88
    • 0022559830 scopus 로고
    • 1 catalyzed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man?
    • 1 catalyzed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man? Arch. Toxicol., 58:165-170,1986.
    • (1986) Arch. Toxicol , vol.58 , pp. 165-170
    • Plummer, A.1    Boobis, A.R.2    Davies, D.S.3
  • 89
    • 0021130765 scopus 로고
    • Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
    • Ayesh, R., Idle, J. R., Ritchie, J. C., Crothers, M. J., and Hetzel, M. R. Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature (Lond.), 312:169-170,1984.
    • (1984) Nature (Lond.) , vol.312 , pp. 169-170
    • Ayesh, R.1    Idle, J.R.2    Ritchie, J.C.3    Crothers, M.J.4    Hetzel, M.R.5
  • 91
    • 84912886080 scopus 로고
    • Biochemical and molecular epidemiology of human cancer indicators of carcinogen exposure, DNA damage, and genetic predisposition
    • D. J. Birkett (ed.) London: Taylor and Francis, in press
    • Harris, C. C., Weston, A., Willey, J. C., Trivers, G. E., and Mann, D. L. Biochemical and molecular epidemiology of human cancer indicators of carcinogen exposure, DNA damage, and genetic predisposition. In: D. J. Birkett (ed.), Microsomes and Drug Oxidations (Proceedings of the Seventh International Symposium). London: Taylor and Francis, in press, 1988.
    • (1988) Microsomes and Drug Oxidations (Proceedings of the Seventh International Symposium)
    • Harris, C.C.1    Weston, A.2    Willey, J.C.3    Trivers, G.E.4    Mann, D.L.5
  • 92
    • 84931699446 scopus 로고
    • The debrisoquine hydroxilation [sic] phenotype and the acetylator phenotype as genetic risk factors for the occurrence of larynx and pharynx carcinoma
    • Suppl. 5
    • Ritter, J., Somasundaram, R., Heinemeyer, G., and Roots, I. The debrisoquine hydroxilation [sic] phenotype and the acetylator phenotype as genetic risk factors for the occurrence of larynx and pharynx carcinoma. Acta Pharmacol. Toxicol., 59 (Suppl. 5): 221, 1986.
    • (1986) Acta Pharmacol. Toxicol , vol.59 , pp. 221
    • Ritter, J.1    Somasundaram, R.2    Heinemeyer, G.3    Roots, I.4
  • 93
    • 0023193252 scopus 로고
    • Genetic predisposition to bladder cancer, ability to hydroxylate debrisoquine and mephenytoin as risk factors
    • Kaisary, A., Smith, P., Jaczq, E., McAllister, C. B., Wilkinson, G. R., Ray, W. A., and Branch, R. A. Genetic predisposition to bladder cancer, ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res., 47: 5488–5493, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 5488-5493
    • Kaisary, A.1    Smith, P.2    Jaczq, E.3    McAllister, C.B.4    Wilkinson, G.R.5    Ray, W.A.6    Branch, R.A.7
  • 94
    • 0018902754 scopus 로고
    • Research on esophageal cancer in China: a review
    • Yang, C. S. Research on esophageal cancer in China: a review. Cancer Res., 40:2633-2644,1980.
    • (1980) Cancer Res. , vol.40 , pp. 2633-2644
    • Yang, C.S.1
  • 95
    • 0022829026 scopus 로고
    • Microsomal enzymes of cholesterol biosynthesis: purification of lanosterol 14a-methyl demethylase cytochrome P-450 from hepatic microsomes
    • Trzaskos, J., Kawata, S., and Gaylor, J. C. Microsomal enzymes of cholesterol biosynthesis: purification of lanosterol 14a-methyl demethylase cytochrome P-450 from hepatic microsomes. J. Biol. Chem., 261:14651-14657, 1986.
    • (1986) J. Biol. Chem. , vol.261 , pp. 14651-14657
    • Trzaskos, J.1    Kawata, S.2    Gaylor, J.C.3
  • 96
    • 0023180688 scopus 로고
    • Purification and characterization of human placental aromatase cytochrome P-450
    • Kellis, J. T., Jr., and Vickery, L. E. Purification and characterization of human placental aromatase cytochrome P-450. J. Biol. Chem., 262:4413-4420,1987.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4413-4420
    • Kellis, J.T.1    Vickery, L.E.2
  • 97
    • 0023259588 scopus 로고
    • Evidence for functional and structural multiplicity of pregnenolone- 16α-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes
    • Graves, P. E., Kaminsky, L. S., and Halpert, J. Evidence for functional and structural multiplicity of pregnenolone- 16α-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes. Biochemistry, 26: 3887–3894, 1987.
    • (1987) Biochemistry , vol.26 , pp. 3887-3894
    • Graves, P.E.1    Kaminsky, L.S.2    Halpert, J.3
  • 98
    • 0022511389 scopus 로고
    • Identification of intratissue sites for xenobiotic activation and detoxication
    • New York: Plenum Publishing Corp
    • Baron, J., Voigt, J. M., Whitter, T. B., Kawabata, T. T., Knapp, S. A., Guengerich, F. P., and Jakoby, W. B. Identification of intratissue sites for xenobiotic activation and detoxication. Adv. Exp. Med., 197:119-144. New York: Plenum Publishing Corp., 1986.
    • (1986) Adv. Exp. Med , vol.197 , pp. 119-144
    • Baron, J.1    Voigt, J.M.2    Whitter, T.B.3    Kawabata, T.T.4    Knapp, S.A.5    Guengerich, F.P.6    Jakoby, W.B.7
  • 99
    • 0018166425 scopus 로고
    • Tumorigenicity studies with diol-epoxides of benzo[α]-pyrene which indicate that (+) trans-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tet-rahydrobenzo[a]pyrne is an ultimate carcinogen in newborn mice
    • Kapitulnik, J., Wislocki, P. G., Levin, W., Yagi, H., Jerina, D. M., and Conney, A. H. Tumorigenicity studies with diol-epoxides of benzo[α]-pyrene which indicate that (+) trans-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tet-rahydrobenzo[a]pyrne is an ultimate carcinogen in newborn mice. Cancer Res., 38: 354-358,1978.
    • (1978) Cancer Res. , vol.38 , pp. 354-358
    • Kapitulnik, J.1    Wislocki, P.G.2    Levin, W.3    Yagi, H.4    Jerina, D.M.5    Conney, A.H.6
  • 100
    • 0021880336 scopus 로고
    • Enzymatic activation of chemicals to toxic metabolites
    • Guengerich, F. P., and Liebler, D. C. Enzymatic activation of chemicals to toxic metabolites. CRC Crit Rev. Toxicol., 14:259-307, 1985.
    • (1985) CRC Crit Rev. Toxicol. , vol.14 , pp. 259-307
    • Guengerich, F.P.1    Liebler, D.C.2
  • 101
    • 0022497049 scopus 로고
    • In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats
    • Hogy, L. L., and Guengerich, F. P. In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. Cancer Res., 46: 3932–3938, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 3932-3938
    • Hogy, L.L.1    Guengerich, F.P.2
  • 102
    • 0023619510 scopus 로고
    • Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats
    • Mattocks, A. R., and Driver, H. E. Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats. Chem.-Biol. Interact, 63:91-104,1987.
    • (1987) Chem.-Biol. Interact , vol.63 , pp. 91-104
    • Mattocks, A.R.1    Driver, H.E.2
  • 103
    • 0003621701 scopus 로고
    • Pharmacokinetic model of aromatic amine-induced urinary bladder carcinogenesis in beagle dogs administered 4-aminobiphenyl
    • C. M. King, L. J. Romano, and D. Schuetzle (eds.) New York: Elsevier Scientific Publishing Co., Inc
    • Kadlubar, F. F., Dooley, K. L., Benson, R. W., Roberts, D. W., Butler, M. A., Teitel, C. H., Bailey, J. R., and Young, J. F. Pharmacokinetic model of aromatic amine-induced urinary bladder carcinogenesis in beagle dogs administered 4-aminobiphenyl. In: C. M. King, L. J. Romano, and D. Schuetzle (eds.), Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp. 173–180. New York: Elsevier Scientific Publishing Co., Inc., 1987.
    • (1987) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes , pp. 173-180
    • Kadlubar, F.F.1    Dooley, K.L.2    Benson, R.W.3    Roberts, D.W.4    Butler, M.A.5    Teitel, C.H.6    Bailey, J.R.7    Young, J.F.8
  • 104
    • 0020366526 scopus 로고
    • Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues
    • Dannan, G. A., and Guengerich, F. P. Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues. Mol. Pharmacol., 22:787-794, 1982.
    • (1982) Mol. Pharmacol. , vol.22 , pp. 787-794
    • Dannan, G.A.1    Guengerich, F.P.2
  • 105
    • 0021747810 scopus 로고
    • Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme
    • Williams, D. E., Ziegler, D. M., Nordin, D. J., Hale, S. E., and Masters, B. S. S. Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme. Biochem. Biophys. Res. Commun., 125:116-122,1984.
    • (1984) Biochem. Biophys. Res. Commun. , vol.125 , pp. 116-122
    • Williams, D.E.1    Ziegler, D.M.2    Nordin, D.J.3    Hale, S.E.4    Masters, B.S.S.5
  • 106
    • 0021707098 scopus 로고
    • Arachidonic acid-dependent cooxidation: a potential pathway for the activation of chemical carcinogens in vivo
    • Krauss, R. S., and Eling, T. E. Arachidonic acid-dependent cooxidation: a potential pathway for the activation of chemical carcinogens in vivo. Biochem. Pharmacol., 33:3319-3324,1984.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 3319-3324
    • Krauss, R.S.1    Eling, T.E.2
  • 107
    • 0022258515 scopus 로고
    • Prostaglandin H synthase-dependent epoxidation of aflatoxin B
    • Battista, J. R., and Marnett, L. J. Prostaglandin H synthase-dependent epoxidation of aflatoxin B,. Carcinogenesis (Lond.), 6:1227-1229,1985.
    • (1985) Carcinogenesis (Lond.) , vol.6 , pp. 1227-1229
    • Battista, J.R.1    Marnett, L.J.2
  • 108
    • 0005380150 scopus 로고
    • Arachidonic acid metabolism and tumor initiation
    • L. J. Marnett (ed.) The Hague: Martinus Nihoff Publishing
    • Marnett, L. J. Arachidonic acid metabolism and tumor initiation. In: L. J. Marnett (ed.), Arachidonic Acid Metabolism and Tumor Initiation, pp. 39–82. The Hague: Martinus Nihoff Publishing, 1985.
    • (1985) Arachidonic Acid Metabolism and Tumor Initiation , pp. 39-82
    • Marnett, L.J.1
  • 109
    • 0021806856 scopus 로고
    • Characterization of rat cytochrome p-450mc synthesized in Saccharomyces cerevisiae
    • Sakaki, T., Oeda, K., Miyoshi, M., and Ohkawa, H. Characterization of rat cytochrome p-450mc synthesized in Saccharomyces cerevisiae. J. Biochem. (Tokyo), 98:167-175,1985.
    • (1985) J. Biochem. (Tokyo) , vol.98 , pp. 167-175
    • Sakaki, T.1    Oeda, K.2    Miyoshi, M.3    Ohkawa, H.4
  • 110
    • 0023254839 scopus 로고
    • 4 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells
    • 4 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells. J. Biochem. (Tokyo), 101: 1129-1139,1987.
    • (1987) J. Biochem. (Tokyo) , vol.101 , pp. 1129-1139
    • Imai, Y.1
  • 111
    • 0023664028 scopus 로고
    • Rat testosterone 7a-hydroxylase: isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene
    • Nagata, K., Matsunaga, T., Gillette, J., Gelboin, H. V., and Gonzalez, F. J. Rat testosterone 7a-hydroxylase: isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. J. Biol. Chem., 262; 2787–2793, 1987.
    • (1987) J. Biol. Chem , vol.262 , pp. 2787-2793
    • Nagata, K.1    Matsunaga, T.2    Gillette, J.3    Gelboin, H.V.4    Gonzalez, F.J.5
  • 112
    • 0022467917 scopus 로고
    • Oxidation of quinidine by human liver cytochrome P-450
    • Guengerich, F. P., Müler-Enoch, D., and Blair, I. A. Oxidation of quinidine by human liver cytochrome P-450. Mol. Pharmacol., 30:287-295,1986.
    • (1986) Mol. Pharmacol. , vol.30 , pp. 287-295
    • Guengerich, F.P.1    Müler-Enoch, D.2    Blair, I.A.3
  • 113
    • 0023355128 scopus 로고
    • Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition
    • Knodell, R. G., Hall, S. D., Wilkinson, G. R., and Guengerich, F. P. Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. J. Pharmacol. Exp. Ther., 241:1112-1119, 1987.
    • (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 1112-1119
    • Knodell, R.G.1    Hall, S.D.2    Wilkinson, G.R.3    Guengerich, F.P.4
  • 114
    • 84965833001 scopus 로고
    • Relationship between tolbutamide hydroxylation and other cytochrome P-450 dependent oxidations in human liver microsomes
    • D. J. Birkett (ed.) London: Taylor and Francis, in press
    • Miners, J. O., Robson, R. A., Smith, K. J., McManus, M. E., and Birkett, D. J. Relationship between tolbutamide hydroxylation and other cytochrome P-450 dependent oxidations in human liver microsomes. In: D. J. Birkett (ed.), Microsomes and Drug Oxidations (Seventh International Symposium). London: Taylor and Francis, in press, 1988.
    • (1988) Microsomes and Drug Oxidations (Seventh International Symposium)
    • Miners, J.O.1    Robson, R.A.2    Smith, K.J.3    McManus, M.E.4    Birkett, D.J.5
  • 115
    • 0017818061 scopus 로고
    • Modeling the uptake, metabolism, and excretion of dichlo-romethane by man
    • Peterson, J. E. Modeling the uptake, metabolism, and excretion of dichlo-romethane by man. Am. Ind. Hyg. Assoc. J., 39:41-47,1978.
    • (1978) Am. Ind. Hyg. Assoc. J. , vol.39 , pp. 41-47
    • Peterson, J.E.1
  • 117
    • 0020742162 scopus 로고
    • Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles
    • Straubinger, R. M., Hong, K., Friend, D. S., and Papahadjopoulos, D. Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles. Cell, 32:1069-1079,1983.
    • (1983) Cell , vol.32 , pp. 1069-1079
    • Straubinger, R.M.1    Hong, K.2    Friend, D.S.3    Papahadjopoulos, D.4
  • 118
    • 0020286103 scopus 로고
    • Injection of proteins into primary rat hepatocytes by erythrocyte-mediated techniques
    • Docherty, P. A., and Aronson, N. N., Jr. Injection of proteins into primary rat hepatocytes by erythrocyte-mediated techniques. Biochem. Biophys. Res. Commun., 109:527-532,1982.
    • (1982) Biochem. Biophys. Res. Commun. , vol.109 , pp. 527-532
    • Docherty, P.A.1    Aronson, N.N.2
  • 119
    • 0021050127 scopus 로고
    • Erythrocyte-mediated microinjection, a technique to study protein degradation in muscle cells
    • McElligott, M. A., and Dice, J. F. Erythrocyte-mediated microinjection, a technique to study protein degradation in muscle cells. Biochem. J., 216: 559-566,1983.
    • (1983) Biochem. J. , vol.216 , pp. 559-566
    • McElligott, M.A.1    Dice, J.F.2
  • 120
    • 0022438848 scopus 로고
    • Models of hepato-carcinogenesis in the rat-contrasts and comparisons
    • Goldsworthy, T. L., Hanigan, M. H., and Pitot, H. C. Models of hepato-carcinogenesis in the rat-contrasts and comparisons. CRC Crit. Rev. Toxicol., 17:61-89, 1986.
    • (1986) CRC Crit. Rev. Toxicol. , vol.17 , pp. 61-89
    • Goldsworthy, T.L.1    Hanigan, M.H.2    Pitot, H.C.3
  • 121
    • 84965819533 scopus 로고
    • Factors affecting the usefulness of drugs
    • Ed. 3, Chap. 2 Philadelphia: W. B. Saunders Co
    • Cline, M. J., and Haskell, C. M. Factors affecting the usefulness of drugs. Cancer Chemotherapy, Ed. 3, Chap. 2, pp. 13–30. Philadelphia: W. B. Saunders Co., 1980.
    • (1980) Cancer Chemotherapy , pp. 13-30
    • Cline, M.J.1    Haskell, C.M.2
  • 122
    • 9844221427 scopus 로고
    • Antineoplastic drugs
    • H. Kant, W. H. E. Roschlau, and E. M. Sellers (eds.) Ed. 4, Chap. 59 Toronto, Canada: University of Toronto Press
    • Erlichman, C., and Kerr, I. G. Antineoplastic drugs. In: H. Kant, W. H. E. Roschlau, and E. M. Sellers (eds.), Principles of Medical Pharmacology, Ed. 4, Chap. 59, pp. 699–710. Toronto, Canada: University of Toronto Press, 1985.
    • (1985) Principles of Medical Pharmacology , pp. 699-710
    • Erlichman, C.1    Kerr, I.G.2
  • 123
    • 0023157369 scopus 로고
    • Hepatic drug metabolizing enzymes in primary and secondary tumors of human liver
    • El Mouelhi, M., Didolkar, M. S., Elias, E. G., Guengerich, F. P., and Kauffman, F. C. Hepatic drug metabolizing enzymes in primary and secondary tumors of human liver. Cancer Res., 47:460-466,1987.
    • (1987) Cancer Res. , vol.47 , pp. 460-466
    • El Mouelhi, M.1    Didolkar, M.S.2    Elias, E.G.3    Guengerich, F.P.4    Kauffman, F.C.5
  • 125
    • 0021205298 scopus 로고
    • Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450
    • Marinello, A. J., Bansal, S. K., Paul, B., Koser, P. L., Love, J., Struck, R. F., and Gurtoo, H. L. Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450. Cancer Res., 44:4615-4621,1984.
    • (1984) Cancer Res. , vol.44 , pp. 4615-4621
    • Marinello, A.J.1    Bansal, S.K.2    Paul, B.3    Koser, P.L.4    Love, J.5    Struck, R.F.6    Gurtoo, H.L.7
  • 127
    • 0021368325 scopus 로고
    • Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-α-(2-methylazo)-p-toluamide, the azo derivative of procarbazine
    • Prough, R. A., Brown, M. I., Dannan, G. A., and Guengerich, F. P. Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-α-(2-methylazo)-p-toluamide, the azo derivative of procarbazine. Cancer Res., 44:543-548,1984.
    • (1984) Cancer Res. , vol.44 , pp. 543-548
    • Prough, R.A.1    Brown, M.I.2    Dannan, G.A.3    Guengerich, F.P.4
  • 128
    • 0021322055 scopus 로고
    • Stereoselective monooxygenation of carcinostatic l-(2-chloroethyl)-3-(cy-clohexyl)-1 -nitrosourea and l-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes
    • Potter, D. W., Levin, W., Ryan, D. E., Thomas, P. E., and Reed, D. J. Stereoselective monooxygenation of carcinostatic l-(2-chloroethyl)-3-(cy-clohexyl)-1 -nitrosourea and l-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes. Biochem. Pharmacol., 55:609-613,1984.
    • (1984) Biochem. Pharmacol. , vol.55 , pp. 609-613
    • Potter, D.W.1    Levin, W.2    Ryan, D.E.3    Thomas, P.E.4    Reed, D.J.5
  • 129
    • 0038134267 scopus 로고
    • Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats
    • Cowan, K. H., Batist, G., Tulpule, A., Sinha, B. K., and Myers, C. E. Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proc. Natl. Acad. Sci. USA, 83:9328-9332,1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 9328-9332
    • Cowan, K.H.1    Batist, G.2    Tulpule, A.3    Sinha, B.K.4    Myers, C.E.5
  • 130
    • 0023547074 scopus 로고
    • Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats
    • Carr, B. I. Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats. Cancer Res., 47:5577-5583, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 5577-5583
    • Carr, B.I.1
  • 131
    • 0018736351 scopus 로고
    • Clinical pharmacokinetics of cyclophosphamide
    • Colvin, M., and Grochow, L. B. Clinical pharmacokinetics of cyclophosphamide. Clin. Pharmacokinet., 4:380-394,1979.
    • (1979) Clin. Pharmacokinet. , vol.4 , pp. 380-394
    • Colvin, M.1    Grochow, L.B.2
  • 132
    • 0022574425 scopus 로고
    • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism: purification and characterization of two similar forms involved in the reaction
    • Shimada, T., Misono, K. S., and Guengerich, F. P. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism: purification and characterization of two similar forms involved in the reaction. J. Biol. Chem., 261: 909–921, 1986.
    • (1986) J. Biol. Chem. , vol.261 , pp. 909-921
    • Shimada, T.1    Misono, K.S.2    Guengerich, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.