FK 482, A new orally active cephalosporin synthesis and biological properties

The Journal of Antibiotics

Volumn 41, Issue 6, 1988, Pages 828-830

  Inamoto, Yoshiko ^a   Chiba, Toshiyuki ^a   Kamimura, Toshiaki ^a   Takaya, Takao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CEFACLOR; CEFDINIR; CEFIXIME;

ANTIMICROBIAL ACTIVITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; LETTER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ADMINISTRATION, ORAL; ANIMAL; CEPHALOSPORINS; DOGS; MICE; RABBITS; RATS;

EID: 0023951374     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.41.828     Document Type: Article

References (6)

1. Yamanaka, H.; H. Takasugi, T. Masugi, H. Kochi, K. Miyai & T. Takaya:Studies on β-lactam antibiotics. VIII. Structure-activity relationships of 7β-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem-4-carboxylic acid. J. Antibiotics 38: 1068—1076, 1985
2. Yamanaka, H.; T. Chiba, K. Kawabata, H. Takasugi, T. Masugi & T. Takaya: Studies on β-lactam antibiotics. IX. Synthesis and biological activity of a new orally active cephalosporin, cefixime (FK027). J. Antibiotics 38: 1738–1751, 1985
3. Yamanaka, H.; K. Kawabata, K. Miyai, H. Takasugi, T. Kamimura, Y. Mine& T. Takaya: Studies on β-lactam antibiotics. X. Synthesis and structure-activity relationships of 7β-[(Z)-2-(2-amino - 4 - thiazolyl) - 2 - (carboxymethoxyimino)-acetamido]cephalosporin derivatives. J. Antibiotics 39: 101 — 110, 1986
4. Kawabata, K.; H. Yamanaka, H. Takasugi & T. Takaya: Studies on β-lactam antibiotics. XIII. Synthesis and structure-activity relationships of 7β-[(Z)-2-aryl-2-carboxymethoxyimino-acetamido]-3-vinylcephalosporins. J. Antibiotics 39: 404–414, 1986
5. Takaya, T.; T. Kamimura, Y. Watanabe, Y. Matsumoto, S. Tawara, F. Shibayama, Y. Mine& S. Kuwahara: FK482, a new orally active cephalosporin: In vitro antibacterial activity. Program and Abstracts of the 27th Intersci. Conf. on Antimicrob. Agents Chemother., No. 652, p. 210, New York, Oct. 4–7, 1987
6. Ochiai, M.; A. Morimoto, Y. Matsushita& T. Okada: Synthesis and structure-activity relationships of 7β-[2-(2-aminothiazol-4-yl)acetamido]cephalosporin derivatives. IV. Synthesis of 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid derivatives and related compounds. J. Antibiotics 34: 160–170, 1981