The formation of reactive intermediates in the MAO-catalyzed oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Toxicology

Volumn 49, Issue 2-3, 1988, Pages 513-519

  Trevor, A J ^a   Castagnoli, N ^a   Singer, T P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Monoamine oxidase; Nigrostriatal neurotoxicity; Radical intermediates; Reactive metabolites

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING); FREE RADICAL;

ANIMAL CELL; METABOLIC ACTIVATION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; BIOTRANSFORMATION; MONOAMINE OXIDASE; OXIDATION-REDUCTION; PYRIDINES; RECEPTORS, DOPAMINE; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023950806     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(88)90037-6     Document Type: Article

References (22)

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