Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of μ opioid receptors in mice

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 337, Issue 4, 1988, Pages 423-428

  Baba, Miwa ^a   Oishi, Ryozo ^a   Saeki, Kiyomi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

D Ala2, McPhe4, Gly(ol)5 enkephalin; Blood brain barrier; Buprenorphine; Morphine; Opioids; Sodium fluorescein

Indexed keywords

BUPRENORPHINE; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ETHYLKETAZOCINE; FLUORESCEIN SODIUM; LEUCINE ENKEPHALIN[2 DEXTRO THREONINE]; MORPHINE; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALOXONE; PENTAZOCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD LEVEL; BRAIN LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; BLOOD-BRAIN BARRIER; BUPRENORPHINE; CARBON DIOXIDE; FLUORESCEIN; FLUORESCEINS; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED STRAINS; MORPHINE; NARCOTICS; PENTAZOCINE; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0023950370     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00169534     Document Type: Article

References (33)

1. Reinitiation of sensitivity to naloxone by a single narcotic injection in postaddicted mice
2. Selectivities of opioid peptide analogues as agonists and antagonists at the δ-receptor
3. ICI 174864: A highly selective antagonist for the opioid δ-receptor
4. Histamine- and acetylcholine-induced changes in the permeability of the blood-brain of normotensive and spontaneously hypertensive rats
5. Opiate interaction with cholinergic neurons
6. Evidence for a functional cholinergic innervation of cerebral arteries
7. Effect of morphine on tyrosine hydroxylase activity in mouse brain
8. Multiple opioid receptors: Criteria for identification and classification
9. Fluorescein spectrophotofluorometry: A sensitive quantitative method for evaluating the blood brain barrier
10. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
11. Analogues of β-LPH 61–64 possessing selective agonist activity at µ-opiate receptors
12. Opioid αreceptor involvement in supraspinal and spinal antinociception in mice
13. Spread of sodium fluorescein in normal brain tissue
14. Opioid analgesics and antagonists
15. Neural control of brain microvessel function
16. Properties of a selective kappa agonist. U-50,488H
17. Enhanced naloxone distribution to the brain by morphine pretreatment in mice
18. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties
19. Alterations in the antagonism by naloxone of morphine-induced respiratory depression and analgesia after morphine pretreatment
20. Morphine-induced changes in histamine dynamics in mouse brain
21. In vivo binding of naloxone to opioid receptors in morphine-dependent mice
22. Relationship of brain morphine levels to analgesic activity in acutely treated mice and rats and in pellet-implanted mice
23. Identification of opiate receptor binding in intact animals
24. The effect of dibenzazepines (tricyclic antidepressants) on cerebral capillary permeability in the rat in vitro
25. Central noradrenergic regulation of cerebral blood flow and vascular permeability
26. Serotonin neurons project to small blood vessels in the brain
27. Morphine-induced increase in the incorporation of 14-C-tyrosine into 14-C-dopamine and 14-C-norepinephrine in the mouse brain, antagonism by naloxone and tolerance
28. The µ, κ and δ properties of various opioid agonists
29. Penetration barrier to sodium fluorescein and fluorescein-labelled dextrans of various molecular sizes in brain capillaries
30. Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier
31. Increased serotonin turnover in acutely morphine-treated mice
32. Deltakephalin, Tyr-DThr-Gly-Phe-Leu-Thr: A new highly potent and fully specific agonist for 6-receptors