Analgesic and tolerance-inducing effects of the highly selective δ opioid agonist {A figure is presented} enkephalin in mice

European Journal of Pharmacology

Volumn 150, Issue 3, 1988, Pages 347-353

  Kovács, Gábor L ^a   Nyolczas, Noémi ^a   Kriván, Márta ^a   Gulya, Károly ^b  

^a Institute of Pathophysiology   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Analgesia; Physical dependence; Tolerance; Receptor agonists (selective)

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHINE; NALOXONE; OPIATE RECEPTOR;

ANALGESIA; ANIMAL EXPERIMENT; DRUG DEPENDENCE; DRUG TOLERANCE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST;

ANALGESICS; ANIMAL; DRUG TOLERANCE; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MALE; MICE; MICE, INBRED STRAINS; MORPHINE; MORPHINE DEPENDENCE; PAIN; REACTION TIME; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; SENSORY THRESHOLDS; SUBSTANCE-RELATED DISORDERS;

EID: 0023949073     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(88)90017-9     Document Type: Article

References (22)

1. 3H)(2-D-penicillamine,5-D-penicillamine)enkephalin binding to delta-opiate receptors in the rat brain and neuroblastoma-glioma hybrid cell line (NG 108-15)
2. 3H)enkephalin as a highly selective ligand for the delta-binding site
3. A method for determining loss of pain sensitization
4. Fluoresceinmikroskopische Ventrikelliquor und Gehirn
5. Endogenous opioids and related derivatives
6. Metkephamide, a systemically active analog of methionine enkephalin with potent delta receptor selectivity
7. Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids
8. Autoradiographic localization of δ opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog
9. Light microscopic autoradiographic localization of delta opioid receptors in the rat brain by using a highly selective bis-penicillamine cyclic enkephalin analog
10. Conformationally restricted cyclic penicillamine analogues with high selectivity for delta- and mu-opioid receptors
11. Characterization of the kappa subtype of the opiate receptor in the guinea-pig brain
12. Oxytoxin and a C-terminal derivative (Z-Pro-D-Leu) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain
13. On the mode of action of an oxytocin derivative (Z-Pro-D-Leu) in morphine dependence in mice
14. Endogenous opiod peptides: Multiple agonist and receptors
15. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine dependent chronic spinal dog
16. Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors
17. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate anelgesia in mouse
18. Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice
19. Simultaneous quantitative assessment of morphine tolerance and physical dependence
20. The direction of opioid agonist towards mu-, delta- epsilon-receptors in the vas deferens of the mouse and the rat
21. Multiple opiate receptors in peripheral tissue preparations