Concurrent assays of circulating bone gla-protein and bone alkaline phosphatase: Effects of sex, age, and metabolic bone disease

Journal of Clinical Endocrinology and Metabolism

Volumn 66, Issue 5, 1988, Pages 951-957

  Duda, Ralph J ^a   O’brien, John F ^a   Katzmann, Jerry A ^a   Peterson, James M ^a   Mann, Kenneth G ^b   Riggs, B Lawrence ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; OSTEOCALCIN;

ACROMEGALY; ADULT; AGE; AGED; CHRONIC KIDNEY FAILURE; FEMALE; HUMAN; HYPERPARATHYROIDISM; HYPERTHYROIDISM; HYPOPARATHYROIDISM; MAJOR CLINICAL STUDY; MALE; METABOLIC BONE DISEASE; NORMAL HUMAN; OSTEOPOROSIS; SEX; SEX DIFFERENCE;

ADULT; AGE FACTORS; ALKALINE PHOSPHATASE; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIUM-BINDING PROTEINS; FEMALE; HUMAN; MALE; MIDDLE AGE; OSTEOCALCIN; SEX FACTORS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023948105     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-66-5-951     Document Type: Article

References (30)

1. Price P 1983 Osteocalcin. In Peck WA (ed) Bone and Mineral Research, Annual 1, chapt 4. Excerpta Medica, Amsterdam, Oxford, and Princeton, p 157
2. Price PA, Parthemore JG, Deftos LJ 1980 New biochemical marker for bone metabolism: measurement by radioimmunoassay of bone gla protein in the plasma of normal subjects and patients with bone disease. J Clin Invest 66:878
3. Deftos LJ, Parthemore JG, Price PA 1982. Changes in plasma bone Gla protein during treatment of bone disease. Calcif Tissue Int 34:121
4. Delmas PD, Wahner HW, Mann K, Riggs BL 1983 Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein. J Lab Clin Med 102:470
5. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ 1984 Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1:1091
6. Delmas PD, Malaval L, Arlot ME, Meunier PJ 1985 Serum bone Gla-protein compared to bone histomorphometry in endocrine diseases. Bone 6:339
7. 47Ca-kinetics. Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, and urinary hydroxyproline excretion. J Clin Invest 76:2254
8. Slovik DM, Gundberg CM, Neer RM, Lian JB 1984 Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting. J Clin Endocrinol Metab 59:228
9. Price PA, Williamson MK, Lothringer JW 1981 Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem 256:12760
10. Riggs BL, Tsai K-S, Mann KG 1986 Effect of acute increases in bone matrix degradation on circulating levels of bone-Gla protein. J Bone Mineral Res 1:539
11. Horne M, Cornish CJ, Posen S 1968 Use of urea denaturation in the identification of human alkaline phosphatases. J Lab Clin Med 72:906
12. Green S, Antiss CL, Fishman WH 1971 Automated differential isoenzyme analysis. II. The fractionation of serum alkaline phosphatases into “liver, ” “intestinal, ” and other components. Enzym-ologia 41:9
13. Behr W, Barnert J 1986 Quantification of bone alkaline phosphatase in serum by precipitation with wheat germ lectin: a simplified method and its clinical plausibility. Clin Chem 32:1960
14. Schoenau E, Herzog KH, Boehles HJ 1986 Liquid-chromatographic determination of isoenzymes of alkaline phosphatase in serum and tissue homogenates. Clin Chem 32:816
15. Lawson GM, Katzmann JA, Kimlinger TK, O’Brien JF 1985 Isolation and preliminary characterization of a monoclonal antibody which interacts preferentially with the liver isoenzyme of human alkaline phosphatase. Clin Chem 31:381
16. Statland BE, Nishi HH, Young DS 1972 Serum alkaline phosphatase: total activity and isoenzyme determinations made by use of the centrifugal fast analyzer. Clin Chem 18:1468
17. Delmas PD, Demiaux B, Malaval L, Chapuy MC, Meunier PJ 1986 Serum bone gla-protein is not a sensitive marker of bone turnover in Paget’s disease of bone. Calcif Tissue Int 38:60
18. Delmas PD, Chatelain P, Malaval L, Bonne G 1986 Serum bone Gla-protein in growth hormone deficient children. J Bone Mineral Res 1:333
19. Epstein E, Kiechle FL, Artiss JD, Zak B 1986 The clinical use of alkaline phosphatase enzymes. Clin Lab Med 6:491
20. Stepan J, Pacovsky V, Horn V, Silinkova-Malkova E, Vokrouhlicka O, Konopasek B, Formankova J, Hrba J, Marek J 1978 Relationship of the activity of the bone isoenzyme of serum alkaline phosphatase to urinary hydroxyproline excretion in metabolic and neoplastic bone diseases. Eur J Clin Invest 8:373
21. Chyun YS, Kream BE, Raisz LG 1984 Cortisol decreases bone formation by inhibiting periosteal cell proliferation. Endocrinology 114:477
22. Meunier PJ, Dempster DW, Edouard C, Chapuy MC, Arlot M, Charhon S 1984 Bone histomorphometry in corticosteroid-induced osteoporosis and Cushing’s syndrome. Adv Exp Med 171:191
23. Majeska RJ, Nair BC, Rodan GA 1985 Glucocorticoid regulation of alkaline phosphatase in the osteoblastic osteosarcoma cell line ROS 17-2.8. Endocrinology 116:170
24. Delmas PD, Wilson DM, Mann KG, Riggs BL 1983 Effect of renal function on plasma levels of bone Gla-protein. J Clin Endocrinol Metab 57:1028
25. Malluche HH, Faugere M-C, Fanti P, Price PA 1984 Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. Kidney Int 26:869
26. Epstein S, Traberg H, Raja R, Poser J 1985 Serum and dialysate osteocalcin levels in hemodialysis and peritoneal dialysis patients and after renal transplantation. J Clin Endocrinol Metab 60:1253
27. Gundberg CM, Weinstein RS 1986 Multiple immunoreactive forms of osteocalcin in uremic serum. J Clin Invest 77:1762
28. Delmas PD, Demiaux B, Malaval L, Chapuy MC, Edourad C, Meunier PJ 1986 Serum bone gamma carboxyglutamic-acid-con-taining protein in primary hyperparathyroidism and in malignant hypercalcemia: comparison with bone histomorphometry. J Clin Invest 77:985
29. 99mTc-HDP for the detection of bone metastasis. Eur J Nucl Med 8:118
30. Rodan GA, Rodan SB 1984 Expression of the osteoblast phenotype. In Peck WA (ed) Bone and Mineral Research, Annual 2, chapt 6. Elsevier, Amsterdam, p 244