Human fibroblasts from cancer patients: lifespan and transformed phenotype in vitro and role of mesenchyme in vivo

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 199, Issue 2, 1988, Pages 313-325

  Azzarone, B ^a   Chaponnier, C ^c   Krief, P ^a   Mareel, M ^b   Suarez, H ^d   Macieira Coelho, A ^a  

^a INSERM   (France)

^b Lab of Experimental Cancerology   (Belgium)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d Institut de Recherches Scientifiques sur le Cancer   (France)

Author keywords

Alteration in vitro; Human fibroblasts

Indexed keywords

INTERLEUKIN 2 RECEPTOR; MEMBRANE ANTIGEN;

CANCER PATIENT; CELL CULTURE; CELL LINE; CELL TRANSFORMATION; CYTOLOGY; FIBROBLAST; HEREDITY; HUMAN; HUMAN CELL; LIFESPAN; MESENCHYME; PRIORITY JOURNAL;

AGE FACTORS; CELL DIVISION; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; HUMAN; PHENOTYPE; SKIN; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0023947993     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(88)90211-4     Document Type: Article

References (59)

1. Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata
2. Role of cytoskeletal elements in the retractile activity of human skin fibroblasts
3. Further characterization of the defects of skin fibroblasts from cancer patients
4. Spontaneous transformation of human skin fibroblasts derived from neoplastic patients
5. Effect of low dose rate irradiation on the division potential of cells in vitro
6. Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells
7. Fibrin clot retraction in normal and transformed avian fibroblasts
8. Fibrin clot retractile activity in normal, established, and tumorigenic human epithelial cells in culture
9. Abnormal properties of skin fibroblasts from patients with breast cancer
10. 4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin
11. Analysis of the expression of the 4F2 surface antigen in normal and neoplastic fibroblastic human cells of embryonic and adult origin
12. Evolution in the structure and distribution of 4F2-antigen from the oncofetal to the adult phenotype of human fibroblasts
13. Monoclonal antibody defining fibroblasts appearing in fetal and neoplastic tissues
14. Enhanced collagenase production by fibroblasts derived from human basal cell carcinoma
15. Different agglutinability of fibroblasts underlying various precursor lesion of human uterine cervical carcinoma
16. The actin filament-severing domain gelsolin
17. Chromosome instability in lymphocytes, fibroblasts and colon epithelial-like cells from patients with familial polyposis coli
18. Endothelial-cell proliferation in experimental tumours
19. Effect of low-dose-rate irradiation on the division potential of cells in vitro. V. Human skin fibroblasts from donors with a high risk of cancer
20. Effect of growth arrest on the doubling potential of human fibroblasts in vitro: a possible influence of the donor
21. Sister chromatid exchange induction by benzo[a]pyrene in cultured peripheral blood lymphocytes of lung cancer patients and healthy individuals with or without familial history of neoplasms
22. Regression of mouse mammary gland anlagen in recombinants of Tfm and wild-type tissues: testosterone acts via the mesenchyme
23. Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary gland
24. Fibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro
25. Tumours wounds that do not heal Similarities between tumor stroma generation and wound healing
26. Isolation of human diploid cell variants with enhanced colony-forming efficiency in semisolid medium after a single-step chemical mutagenesis
27. Heteroploid conversion of human skin cells by methylcholantrene
28. The limited in vitro lifetime of human duploïd strains
29. Differential mutagen susceptibility in cultured lymphocytes of normal individuals and cancer patients
30. Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens
31. Hereditary adenomatosis of the colon and rectum: relevance to cancer promotion and cancer control in humans
32. Spontaneous immortalization rate of cultured Chinese hamster cells
33. Tissue interaction in androgen response of embryonic mammary rudiment of mouse: identification of target tissue for testosterone
34. Genetic instability in fibroblasts of patients with thyroid cancers (TC)
35. Organization of actin in epithelial cells during regenerative and neoplastic conditions
36. Genetic predisposition to breast cancer
37. Implications of reorganization of the cell genome for aging and immortalization of dividing cells in vitro
38. Aging, cancer, and the life span of cells in vitro
39. Frequency of UV-induced neoplastic transformation of diploid fibroblasts is higher in xeroderma pigmentosum cells than in normal cells
40. Is invasiveness in vitro characteristic of malignant cells?
41. Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro
42. Replicative life span of cultivated human cells. Effects of donor's age, tissue and genotype
43. Immortalization in culture of rat cells: a genealogic study
44. Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment
45. Spontaneous in vitro transformation of human fibroblasts
46. 60Co gamma rays
47. Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes
48. Chromosomal radiosensitivity during the G2 cell-cycle period of skin fibroblasts from individuals with familial cancer
49. Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten's murine sarcoma virus
50. Actin content and organization in normal and transformed cells in culture
51. Human cell transformation by Simian virus 40 a review
52. Resistance of human cells to oncogenic transformation
53. Occurrence of a fetal fibroblast phenotype in familial breast cancer
54. Skin fibroblast obtained from cancer patients display foetal-like migratory behaviour on collagen gels
55. The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas
56. Chromosomal variation and the establishment of somatic cell lines in vitro
57. Spontaneous in vitro malignant transformation in a xeroderma pigmentosum fibroblast line
58. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines