Quantitative Neuroanatomy in Schizophrenia: A Controlled Magnetic Resonance Imaging Study

Archives of General Psychiatry

Volumn 45, Issue 6, 1988, Pages 533-541

  Kelsoe, John R ^a   Cadet, Jean Lud ^c,d   Pickar, David ^a   Weinberger, Daniel R ^b  

^a Clinical Neuroscience Branch ^*  (United States)

^b Intramural Res Prog Natl I   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d Columbia University School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; BRAIN VENTRICLE; CLINICAL ARTICLE; DENSITY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA;

ADULT; BRAIN; CEREBRAL VENTRICLES; CORPUS CALLOSUM; DILATATION, PATHOLOGIC; FEMALE; HUMAN; MAGNETIC RESONANCE IMAGING; MALE; SCHIZOPHRENIA;

EID: 0023947312     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1988.01800300029003     Document Type: Article

References (94)

1. Alzheimer A: Beitráge zur pathologischen Anatomie der Hirnrinde und zur anatomischen Grundlage einiger Psychosen. Monatsschr Psychiatr Neurol 1897;2:82-120.
2. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L: Postmortem evidence of structural brain changes in schizophrenia: Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatry 1986;43:36-42.
3. Weinberger DR, Kleinman JE, Luchins DJ, Bigelow LB, Wyatt RJ: Cerebellar pathology in schizophrenia: A controlled postmortem study. Am J Psychiatry 1980;137:359-361.
4. Rosenthal R, Bigelow LB: Quantitative brain measurements in chronic schizophrenia. Br J Psychiatry 1972;121:259-264.
5. Bigelow LB, Nasrallah HA, Rauscher FP: Corpus callosum thickness in chronic schizophrenia. Br J Psychiatry 1983;142:284-287.
6. Bogerts B, Meertz E, Schönfeldt-Bausch R: Basal ganglia and limbic system pathology in schizophrenia: A morphometric study of brain volume and shrinkage. Arch Gen Psychiatry 1985;42:784-791.
7. Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L: Cerebral ventricular size and cognitive impairment in chronic schizophrenics. Lancet 1976;2:924-926.
8. Shelton RC, Weinberger DR: Computerized tomography in schizophrenia: A review and synthesis, in Nasrallah HA, Weinberger DR (eds): Handbook of Schizophrenia. Amsterdam, Elsevier Science Publishers, 1986, vol 1:The Neurology of Schizophrenia, pp 207-250.
9. Nyback H, Weisel F-A, Berggren B-M, Hindmarsch T: Computed tomography of the brain in patients with acute psychosis and healthy controls. Acta Psychiatr Scand 1982;65:403-414.
10. Weinberger DR, DeLisi LE, Perman GP, Targum S, Wyatt RJ: Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 1982;39:778-783.
11. Luchins DJ, Meltzer HY: A blind controlled study of occipital cerebral asymmetry in schizophrenia. Psychiatry Res 1983;10:87-95.
12. Pearlson GD, Veroff AF: Computerized tomographic scan changes in manic-depressive illness. Lancet 1981;2:470.
13. Johnstone EC, Crow TJ, Frith CD, Stevens M, Kreel L, Husband J: The dementia of dementia praecox. Acta Psychiatr Scand 1978;57:305-324.
14. Weinberger DR, Torrey EF, Neophytides AN, Wyatt RJ: Lateral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 1979;36:735-739.
15. Moriguchi I: A study of schizophrenic brains by computerized tomographic scans. Folia Psychiatr Neurol Jpn 1981;35:55-72.
16. Weinberger DR, DeLisi LE, Neophytides AN, Wyatt RJ: Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiatry Res 1981;4:65-71.
17. Tanaka Y, Hazama H, Kawahara R, Kobayashi K: Computerized tomography of the brain in schizophrenic patients. Acta Psychiatr Scand 1981;63:191-197.
18. Okasha A, Madkour O, Madg FA: Cortical and central atrophy in chronic schizophrenia, a controlled study, in Perris C, Struwe G, Jansson B (eds): Biological Psychiatry 1981. Amsterdam, Elsevier Science Publishers, 1981, pp 241-245.
19. Takahashi R, Inaba Y, Inanaga K, Kato N, Kumashiro H, Nishimura T, Okuma T, Otskui S, Sakai T, Sato T, Shimazono Y: CT scanning and the investigation of schizophrenia, in Perris C, Struwe G, Jansson B (eds): Biological Psychiatry 1981. Amsterdam, Elsevier Science Publishers, 1981, pp 259-268.
20. Johnstone EC, Owens DGC, Crow TJ, Jagoe R: A CT study of 188 patients with schizophrenia, affective psychosis and neurotic illness, in Perris C, Struwe G, Jansson B (eds): Biological Psychiatry 1981. Amsterdam, Elsevier Science Publishers, 1981, pp 237-240.
21. Okasha A, Madkur O: Cortical and central atrophy in schizophrenia. Acta Psychiatr Scand 1982;65:29-34.
22. Frangos E, Athanassenas G, Gregoriades A, Kapsalakis Z: Lateral cerebral ventricular enlargement in chronic schizophrenia. Enkaphalos 1982;19:64-70.
23. Andreasen NC, Smith MR, Jacoby CG, Dennert JW, Olsen SA: Ventricular enlargement in schizophrenia: Definition and prevalence. Am J Psychiatry 1982;139:292-296.
24. Andreasen NC, Olsen SA, Dennert JW, Smith MR: Ventricular enlargement in schizophrenia: Relationship to positive and negative symptoms. Am J Psychiatry 1982;139:297-302.
25. Reveley AM, Reveley MA, Clifford CA, Murray RM: Cerebral ventricular size in twins discordant for schizophrenia. Lancet 1982;1:540-541.
26. Nasrallah HA, Jacoby CG, McCalley-Whitters M, Kuperman S: Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Arch Gen Psychiatry 1982;39:774-777.
27. Nasrallah HA, Kuperman S, Hamra BJ, McCalley-Whitters M: Clinical differences between schizophrenic patients with and without large cerebral ventricles. J Clin Psychiatry 1983;44:407-409.
28. Woods BT, Wolf J: A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia. Am J Psychiatry 1983;140:1564-1570.
29. Schulz SC, Koller MM, Kishore PR, Hamer RM, Gehl JJ, Friedel RO: Ventricular enlargement in teenage patients with schizophrenia spectrum disorders. Am J Psychiatry 1983;140:1592-1595.
30. Pearlson CG, Garbacz DJ, Breakey WR, Ahn HS, DePaulo JR: Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Res 1984;12:1-9.
31. Pearlson CG, Garbacz DJ, Moberg PJ, Ahn HS, DePaulo JR: Symptomatic, familial perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. J Nerv Ment Dis 1985;173:42-50.
32. Luchins DJ, Lewine RRJ, Meltzer HY: Lateral ventricular size, psychopathology, and medication response in the psychoses. Biol Psychiatry 1984;19:29-44.
33. Schulsinger F, Parnas J, Petersen ET, Schulsinger H, Teasdale TW, Meduick SA, Moller L, Silverton L: Cerebral ventricular size in the offspring of schizophrenic mothers. Arch Gen Psychiatry 1984;41:602-606.
34. Williams AD, Reveley MA, Kolakowska T, Ardern M, Mandelbrote BM: Schizophrenia with good and poor outcome: II. Cerebral ventricular size and its clinical significance. Br J Psychiatry 1985;146:239-246.
35. Dewan MJ, Pandurangi AD, Rice SH, Ramachandran T, Levy B, Boucher M, Yozawitz A, Major LF: Central brain morphology in chronic schizophrenic patients: A controlled CT study. Biol Psychiatry 1983;18:1133-1140.
36. DeMeyer MK, Gilmore R, DeMeyer WE, Hendric H, Edwards M, Franco JN: Third ventricle size and ventricular brain ratio in treatment-resistant psychiatric patients. J Operat Psychiatry 1984;15:2-8.
37. Pandurangi AK, Dewan MJ, Lee SH, Ramachandran T, Levy BF, Boucher M, Yozawitz A, Major L: The ventricular system in chronic schizophrenic patients: A controlled tomography study. Br J Psychiatry 1984;144:172-176.
38. Gluck E, Radu EW, Gerhardt P: A computed tomographic prolective trohoc study of chronic schizophrenics. Neuroradiology 1980;20:167-171.
39. Mundt C, Radu W, Gluck E: Computertomographische Untersuchungen der Liquorräume an chronisch schizophrenen Patienten. Nervenarzt 1980;51:745-748.
40. Gatta WF, Kasper S, Kohlmeyer K, Beckman H: Die kraniale Computer Tomographic in der Schizophrenieforschung. Fortschr Neurol Psychiatr 1981;49:286-291.
41. Boronow J, Pickar D, Ninan PT, Roy A, Hommer D, Linnoila M, Paul SM: Atrophy limited to the third ventricle in chronic schizophrenic patients: Report of a controlled series. Arch Gen Psychiatry 1985;42:266-271.
42. Shelton RC, Karson CN, Doran AR, Pickar D, Bigelow LB, Weinberger DR: Cerebral structural pathology in schizophrenia: Evidence for a selective prefrontal cortical defect. Am J Psychiatry 1988;145:154-163.
43. Doran AR, Boronow J, Weinberger DR, Wolkowitz OM, Breier A, Pickar D: Structural brain pathology in schizophrenia revisited: Prefrontal cortex pathology is inversely correlated with CSF levels of homovanillic acid. Neuropsychopharmacology 1988;1:25-32.
44. Weinberger DR, Torrey EF, Wyatt RJ: Cerebellar atrophy in chronic schizophrenia. Lancet 1979;1;718-719.
45. Lippman S, Manshadi M, Baldwin H, Drasin G, Rice J, Alrajeh S: Cerebellar vermis dimensions on computerized tomographic scans of schizophrenic and bipolar patients. Am J Psychiatry 1982;139:667-668.
46. Heath RG, Franklin DE, Walker CF, Keating JW: Cerebellar vermal atrophy in psychiatric patients. Biol Psychiatry 1982;17:569-583.
47. Nasrallah HA, Rizzo M, Damasio H, McCalley-Whitters M, Kuperman S, Jacoby CG: Neurological differences between paranoid and nonparanoid schizophrenia: II. Computed tomographic findings. J Clin Psychiatry 1982;43:307-309.
48. Heath RG, Franklin DE, Shraberg D: Gross pathology of the cerebellum in patients diagnosed and treated as functional psychiatric disorders. J Nerv Ment Dis 1979;167:585-592.
49. Nasrallah HA, McCalley-Whitters M, Jacoby GC: Cortical atrophy in schizophrenia and mania: A comparative study. J Clin Psychiatry 1982;43:439-441.
50. Dewan MJ, Pandurangi AK, Lee SH, Ramachandran T, Levy BF, Boucher M, Yozawitz A, Major L: Cerebral morphology in chronic schizophrenic patients: A controlled computed tomographic study. Psychiatry Res 1983;10:97-103.
51. Rieder RO, Mann LS, Weinberger DR, van Kammen DP, Post RM: Computed tomographic scans in patients with schizophrenia, schizoaffective, and bipolar affective disorder. Arch Gen Psychiatry 1983;40:735-739.
52. Golden CJ, Graber B, Coffman J, Berg R, Bloch S, Brogan D: Brain density deficits in chronic schizophrenia. Psychiatry Res 1980;3:179-184.
53. Lyon K, Wilson J, Golden CJ, Graber B, Coffman JA, Bloch S: Effects of long-term neuroleptic use on brain density. Psychiatry Res 1981;5:33-37.
54. Golden CJ, Graber B, Coffman J, Berg RA, Newllin DB, Bloch S: Structural deficits in schizophrenia: Identification by tomographic scan measurements. Arch Gen Psychiatry 1981;38:1014-1017.
55. Largen JW, Calderon M, Smith RC: Asymmetries in the density of white and gray matter in the brains of schizophrenic patients. Am J Psychiatry 1983;140:1060-1062.
56. Kanba S, Shima S, Tsukumo D, Masuda Y, Asai M: Brain CT density in chronic schizophrenia. Biol Psychiatry 1984;19:273-274.
57. Coffman JA, Nasrallah HA: Brain density patterns in schizophrenia and mania. J Affective Disord 1984;6:307-315.
58. Luchins DJ, Weinberger DR, Wyatt RJ: Schizophrenia, evidence of a subgroup with reversed cerebral asymmetry. Arch Gen Psychiatry 1979;36:1309-1311.
59. Andreasen NC, Dennert JW, Olsen SA, Damasio AR: Hemispheric asymmetries and schizophrenia. Am J Psychiatry 1982;139:427-430.
60. Luchins DJ, Weinberger DR, Wyatt RJ: Schizophrenia and cerebral asymmetry detected by computed tomography. Am J Psychiatry 1982;139:753-757.
61. Jernigan TL, Zatz LM, Moses JA Jr, Cardellino JP: Computed tomography in schizophrenics and normal volunteers: II. Cranial asymmetry. Arch Gen Psychiatry 1982;39:771-773.
62. Kling AS, Kurtz N, Tachiki K, Orzech A: CT scans in subgroups of chronic schizophrenics. J Psychiatr Res 1983;17:375-384.
63. Tsai LY, Nasrallah HA, Jacoby CG: Hemispheric asymmetries on computed tomographic scans in schizophrenia and mania. Arch Gen Psychiatry 1983;40:1286-1289.
64. Donnelly EF, Weinberger DR, Waldman IN, Wyatt RJ: Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenia patients. J Nerv Ment Dis 1980;168:305-308.
65. Golden CJ, Moses JA, Zelazowski R, Graber B, Zatz LM, Horvath TB, Berger PA: Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics, measurement by the standardized Luria-Nebraska neuropsychological battery. Arch Gen Psychiatry 1980;37:619-623.
66. Golden CJ, MacInnes WD, Ariel RN, Ruedrich SL, Chu C-C, Coffman JA, Graber B, Bloch S: Cross-validation of the ability of the Luria-Nebraska neuropsychological battery to differentiate chronic schizophrenics with and without ventricular enlargement. J Consult Clin Psychol 1982;50:87-95.
67. Weinberger DR, Bigelow LB, Kleinman JE, Klein ST, Rosenblatt JE, Wyatt RJ: Cerebral ventricular enlargement in chronic schizophrenia, an association with poor response to treatment. Arch Gen Psychiatry 1980;37:11-13.
68. Smith RC, Largen J, Calderon M, Schoolar J, Shvartsburd A, Ravichandran GK: CT scans and neuropsychological tests as predictors of clinical response in schizophrenics. Schizophr Bull 1983;19:505-509.
69. Schulz SC, Sinicrope P, Kishore P, Friedel RO: Treatment response and ventricular enlargement in young schizophrenic patients. Schizophr Bull 1983;19:510-512.
70. Luchins DJ, Lewine RJ, Meltzer HY: Lateral ventricular size in the psychoses: Relation to psychopathology and therapeutic and adverse response to medication. Schizophr Bull 1983;19:518-522.
71. DeLisi LE, Schwartz CC, Targum SD, Byrnes SM, Cannon-Spoor E, Weinberger DR, Wyatt RJ: Ventricular brain enlargement and outcome of acute schizophreniform disorder. Psychiatry Res 1983;9:169-171.
72. Besson JAO, Corrigan FM, Cherryman GR, Smith FW: Nuclear magnetic resonance brain imaging in chronic schizophrenia. Br J Psychiatry 1987;150:161-163.
73. Mathew RJ, Partain CL, Prakash R, Kulkarni MV, Logan TP, Wilson WH: A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging. Acta Psychiatr Scand 1985;72:414-421.
74. Nasrallah HA, Andreasen NC, Coffman JA, Olson SC, Dunn VD, Ehrhardt JC, Chapman SM: A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 1986;21:274-282.
75. Andreasen N, Nasrallah HA, Dunn V, Olson SC, Grove WM, Ehrhardt JC, Coffman JA, Crossett JHW: Structural abnormalities in the frontal system in schizophrenia: A magnetic resonance imaging study. Arch Gen Psychiatry 1986;43:136-144.
76. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC: Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res 1984;12:137-147.
77. Mathew RJ, Partain CL: Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients. Am J Psychiatry 1985;142:970-971.
78. Johnstone EC, Crow TJ, Macmillan JF, Owens DG, Bydder GM, Steiner RE: A magnetic resonance study of early schizophrenia. J Neurol Neurosurg Psychiatry 1986;49:136-139.
79. Smith RC, Baumgartner R, Calderon M: Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Res 1987;20:33-46.
80. American Psychiatric Association, Committee on Nomenclature and Statistics: Diagnostic and Statistical Manual of Mental Disorders, ed 3. Washington, DC, American Psychiatric Association, 1980.
81. Oldfield RC: The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 1971;9:97-113.
82. DeArmond SJ, Fusco MM, Dewey MM: Structure of the Human Brain, ed 2. New York, Oxford University Press, 1976.
83. Bradley WG, Adey WR, Hasso AN: Magnetic Resonance Imaging of Brain, Head and Neck. Rockville, Md, Aspen Systems Corp, 1985.
84. Winer BJ: Statistical Principles in Experimental Design. New York, McGraw-Hill International Book Co, 1971, pp 283-296.
85. SAS Institute Inc: Statistical Analysis System (Version S). Cary, NC, SAS Institute Inc, 1985.
86. Reid AC, Matheson MS, Teasdale G: Ventricles in benign intracranial hypertension. Lancet 1980;2:7-8.
87. Nemenyi P: Linear hypothesis: Multiple comparisons, in Kruskal WH, Tamur JM (eds): International Encyclopedia of Statistics. New York, The Free Press, 1978, p 565.
88. Weinberger DR: Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987;44:660-669.
89. Nasrallah HA, Bigelow LB, Rauscher FP, Wyatt RJ: Corpus callosum thickness in schizophrenia, new research abstract NR15. Presented at the American Psychiatric Association Annual Meeting, San Diego, May 16, 1979.
90. Weinberger DR, Berman KF, Iadarola M, Driesen N, Karson C, Coppola R: Hat size in schizophrenia. Arch Gen Psychiatry 1987;44:672.
91. DeLisi LE, Goldin LR: Hat size in schizophrenia. Arch Gen Psychiatry 1987;44:672-673.
92. Stevens JR, Waldmon IN: Hat size in schizophrenia. Arch Gen Psychiatry 1987;44:673.
93. Reveley MA, Reveley AM: Hat size in schizophrenia. Arch Gen Psychiatry 1987;44:673-674.
94. Condon B, Patterson J, Wyper D, Hadley D, Grant R, Teasdale G, Rowan J: Use of magnetic resonance imaging to measure intracranial cerebrospinal fluid volume. Lancet 1986;1:1355-1357.