Glucocorticoid toxicity in the hippocampus: in vitro demonstration

Brain Research

Volumn 453, Issue 1-2, 1988, Pages 367-371

  Sapolsky, Robert M ^a   Packan, Desta R ^a   Vale, Wylie W ^b  

^a STANFORD UNIVERSITY   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

3 Acetylpyridine; Glucocorticoid; Glucocorticoid toxicity; Hippocampus; Kainic acid

Indexed keywords

3 ACETYLPYRIDINE; CORTICOSTERONE; KAINIC ACID; PARAQUAT; SUPEROXIDE;

ANIMAL CELL; CELL CULTURE; FETUS; HIPPOCAMPUS; NEUROTOXICITY; NONHUMAN; RAT;

ANIMAL; CELLS, CULTURED; CORTICOSTERONE; DRUG INTERACTIONS; GLUCOSE; HIPPOCAMPUS; KAINIC ACID; LACTATE DEHYDROGENASE; PARAQUAT; PICROTOXIN; PYRIDINES; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023946137     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(88)90180-1     Document Type: Article

References (21)

1. Rat hippocampal neurons in dispersed cell culture
2. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy
3. A mechanism of paraquat toxicity in mice and rats
4. Pathologic effects of antimetabolites. I. Acute lesions in hypothalamus, peripheral ganglia and adrenal medulla caused by 3-acetylpyridine and prevented by nicotinamide
5. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
6. Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis
7. Brain aging correlates: retardation by hormonal-pharmacological treatments
8. 14C-glucose by rat brain under the influence of corticosterone
9. Selective retention of corticosterone by limbic structures in rat brain
10. Adrenal steroid receptors and actions in the nervous system
11. Glucocorticoid inhibition of glucose uptake by peripheral tissues: old and new evidence, molecular mechanisms and physiological significance
12. High dose dexamethasone decreases regional cerebral glucose utilization in the rat
13. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation
14. A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults
15. Glucocorticoid toxicity in the hippocampus: Temporal aspects of neuronal vulnerability
16. Glucocorticoid toxicity in the hippocampus: Temporal aspects of synergy with kainic acid
17. Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels
18. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis
19. Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications
20. Methodological considerations in culturing peptidergic neurons
21. The role of neuronal metabolic insult in organometal neurotoxicity