Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

Biochemical Pharmacology

Volumn 37, Issue 13, 1988, Pages 2507-2510

  Schellens, J H M ^a   Soons, P A ^a   Breimer, D D ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NIFEDIPINE;

ADULT; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS;

FEMALE; HUMAN; MALE; METABOLIC CLEARANCE RATE; NIFEDIPINE;

EID: 0023943652     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(88)90238-9     Document Type: Article

References (12)

1. Variability in nifedipine pharmacokinetics: a new oxidation polymorphism in man
2. Oxidation of 4-Aryl- and 4-Alkyl-Substituted 2,6-Dimethyl-3,5-bis (alkoxycarbonyl)-1,4-dihydropyridines by Human Liver Microsomes and Immunochemical Evidence for the Involvement of a Form of Cytochrome P-450
3. Nifedipine: kinetics and dynamics in healthy subjects
4. Pharmacokinetics and metabolism of nifedipine
5. Pharmacokinetics and metabolism of nifedipine
6. Variability in drug metabolism: importance of genetic constitution
7. Assessment of in vivo oxidative drug metabolizing enzyme activity in man by applying a cocktail approach
8. Liquid Chromatographic determination of nifedipine in plasma and of its main metabolite in urine
9. Is the probit plot of use to detect polymorphism of drug metabolism ?
10. Impaired metabolic dehydrogenation of nifedipine
11. Investigations on the Metabolism and Protein Binding of Nifedipine. In New Therapy of Ischemic Heart Disease