Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation

Journal of the National Cancer Institute

Volumn 80, Issue 3, 1988, Pages 188-194

  Begin, Michel E ^a   Ells, Greg ^a   Horrobin, David F ^a  

^a Efamol Limited   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; COPPER; FATTY ACID; GAMMA LINOLENIC ACID; INDOMETACIN; IRON; POLYUNSATURATED FATTY ACID;

CELL CULTURE; HUMAN; HUMAN CELL; LIPID PEROXIDATION;

ANTIOXIDANTS; BREAST NEOPLASMS; CELL LINE; CELL SURVIVAL; COPPER; CYTOTOXICITY, IMMUNOLOGIC; FATTY ACIDS, UNSATURATED; FEMALE; FREE RADICALS; HUMAN; INDOMETHACIN; IRON; KINETICS; LIPID PEROXIDES;

EID: 0023941665     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/80.3.188     Document Type: Article

References (29)

1. Bégin M, Das UN, Ells G, et al. Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukotrienes Med 1985;19:177–186
2. Bégin ME, Ells G, Das UN, et al. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. JNCI 1986;77:1053–1062
3. Dippenaar N, Booyens J, Fabbi D, et al. The reversibility of malignancy: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. S Afr Med 1982;62:683–685
4. Booyens J, Engelbrecht P, Le Roux S, et al. Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A and E on the proliferation of human osteogenic sarcoma cells in culture. Prostaglandins Leukotrienes Med 1984;15:15–34
5. Fujiwara F, Todo S, Imashuku S. Antitumor effect of y-linolenic acid on cultured human neuroblastoma cells. Prostaglandins Leukotrienes Med 1986;23:311–320
6. Begin ME, Ells G. Effects of C18 fatty acids on breast carcinoma cells cultured in vitro. Anticancer Res 1987;7:215–218
7. Kappus H. Lipid peroxidation: mechanisms, analysis, enzymology and biological relevance. In: Sies H, ed. Oxidative stress. New York: Academic Press, 1985:273–303
8. Vladimirov YA. Free radical lipid peroxidation in biomembranes: mechanisms, regulation, and biological consequences. In: Johnson JE Jr, Walford R, Hannan D, et al, eds. Free radicals, aging, and degenerative diseases. New York: Liss, 1986:141–195
9. Morisaki N, Ljndsey JA, Snrrs JM, et al. Fatty acid metabolism and cell proliferation. V. Evaluation of pathways for the generation of lipid peroxides. Lipids 1984;19:381–394
10. Gavino VC, Miller JS, Ikareblha SO, et al. Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures. J Lipid Res 1981;22:763–769
11. Koshthara Y, Neichi T, Murota S-I, et al. Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochim Biophys Acta 1984;792:92–97
12. Das UN, Huang YS, Bégin ME, et al. Uptake and distribution of ris-unsaturated fatty acids and their effects on free radical generation in normal and tumor cells in vitro. J Free Radic Biol Med 1986;2:9–14
13. Porter NA, Wagner CR. Phospholipid autoxidation. In: Pryor WA, ed. Advances in free radical biology and medicine, vol 2. London: Pergamon Press, 1986:283–323
14. Haluwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1986;219:1–14
15. Burton GW, Foster DO, Perly B, et al. Biological antioxidants. Philos Trans R Soc Lond [Biol] 1985;311:565–578
16. Schauenstein E, Esterbauer H, Zollner H, eds. Aldehydes in biological systems. London: Pion, 1977
17. Draper HH, McGirr LG, Hadley M. The metabolism of malondialde- hyde. Lipids 1986;21:305–307
18. Dianzani MU. Biochemical effects of saturated and unsaturated aldehydes. In: McBrien DG, Slater TF, eds. Free radical, lipid peroxidation and cancer. London: Academic Press, 1982:129–158
19. Schauenstein E. Effects of low concentrations of aldehydes on tumor cells and tumor growth. In: McBrien DG, Slater TF, eds. Free radical, lipid peroxidation and cancer. London: Academic Press, 1982:159–171
20. Esterbauer H. Aldehydic products of lipid peroxidation. In: McBrien DG, Slater TF, eds. Free radical, lipid peroxidation and cancer. London: Academic Press, 1982:101–128
21. Bird RP, Draper HH. Uptake and oxidation of malonaldehyde by cultured mammalian cells. Lipids 1982;17:519–523
22. 2+ of catalytic activity of the superoxide-producing NADPH oxidase in membrane fractions of human neutrophils and monocytes. J Biol Chem 1985;260:3635–3639
23. Bromberg Y, Pick E. Unsaturated fatty acids as second messengers of superoxide generation by macrophages. Cell Immunol 1983;79:240–252
24. Badwey J A, Curnutte JT, Robinson JM, et al. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. J Biol Chem 1984;259:7870–7877
25. Curnutte JT, Badwey JA, Robinson JM, et al. Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J Biol Chem 1984;259:11851–11857
26. Morimoto YM, Sato E, Nobori K, et al. Effect of calcium ion on fatty acid-induced generation of superoxide in guinea pig neutrophils. Cell Struct Funct 1986;11:143–155
27. Schlager SI, Madden LD, Meltzer MS, et al. Role of macrophage lipids in regulating tumoricidal activity. Cell Immunol 1983;77:52–68
28. Ohlrogge JB, Kernan TB. Toxicity of activated oxygen: lack of dependence on membrane unsaturated fatty acid composition. Biochem Biophys Res Commun 1983;113:301–308
29. Suzuki S. Is lipid peroxidation essential for radiation damage to membranes? Membrane damage and its repair in the thermophilic bacterium Thermus thermophilus HB-8. In: Walden TL Jr, Hughes HN, eds. Proceedings of the international conference on prostaglandins and lipid metabolism in radiation injury, Rockville, MD, Oct 2-3, 1986. New York: Plenum Press, 1987