Plasma Glucose Concentrations at the Onset of Hypoglycemic Symptoms in Patients with Poorly Controlled Diabetes and in Nondiabetics

New England Journal of Medicine

Volumn 318, Issue 23, 1988, Pages 1487-1492

  Boyle, Patrick J ^a   Schwartz, Natalie S ^a   Shah, Suresh D ^a   Clutter, William E ^a   Cryer, Philip E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; JUVENILE DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0023941280     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198806093182302     Document Type: Article

References (35)

1. Maddock RK, Krall LP. Insulin reactions: manifestations and need for recognition of long-acting insulin reactions. Arch Intern Med 1953; 91: 695–703.
2. Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Ann Intem Med 1985; 103: 184–90.
3. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 1987; 316: 1376–83.
4. DeFronzo RA, Hendler R, Christensen N. Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration. Diabetes 1980; 29: 125–31.
5. Santiago JV, Clark WL, Shah SD, Cryer PE. Epinephrine, norepinephrine, glucagon, and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man. J Clin Endocrinol Metab 1980; 51: 877–83.
6. Cryer PE. Does central nervous system adaptation to antecedent glycemia occur in patients with insulin-dependent diabetes mellitus? Ann Intern Med 1985; 103: 284–6.
7. Cryer PE, Gerich JE. Glucose counterregulation, hypoglycemia, and intensive insulin therapy of diabetes mellitus. N Engl J Med 1985; 313: 232–41.
8. Schwartz NS, Clutter WE, Shah SD, Cryer PE. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest 1987; 79: 777–81.
9. Kuzuya H, Blix PM, Horwitz DL, Steiner DN, Rubenstein AH. Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 1977; 26: 22–9.
10. Ensinck JW. Immunoassays for glucagon. In: Lefebvre P, ed. Glucagon: handbook of experimental pharmacology. Vol. 66. New York: SpringerVerlag, 1983:203–21.
11. Schalch DS, Parker ML. A sensitive double antibody immunoassay for human growth hormone in plasma. Nature 1964; 203: 1141–2.
12. Farmer RW, Pierce CE. Plasma cortisol determination: radioimmunoassay and competitive protein binding compared. Clin Chem 1974; 20: 411–4.
13. Shah SD, Clutter WE, Cryer PE. External and internal standards in the single isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine. J Lab Clin Med 1985; 106: 624–9.
14. Pinter JK, Hayashi JA, Watson JA. Enzymic assay of glycerol, dihydroxyacetone, and glyceraldehyde. Arch Biochem Biophys 1967; 121: 404–14.
15. Lowry OH, Passonneau JV, Hasselberger FX, Schulz DW. Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J Biol Chem 1964; 239: 18–30.
16. Cahill GF Jr, Herrera MG, Morgan AP, et al. Hormone-fuel interrelationships during fasting. J Clin Invest 1966; 45: 1751–69.
17. Sussman KE, Crout JR, Marble A. Failure of warning in insulin-induced hypoglycemic reactions. Diabetes 1963; 12: 38–45.
18. Hoeldtke RD, Boden G, Shuman CR, Owen OE. Reduced epinephrine secretion and hypoglycemia unawareness in diabetic autonomie neuropathy. Ann Intern Med 1982; 96: 459–62.
19. Heller SR, Macdonald IA, Herbert M, Tattersall RB. Influence of sympathetic nervous system on hypoglycaemic warning symptoms. Lancet 1987; 2: 359–63.
20. Cryer PE. Diseases of the sympathochromaffin system. In: Felig P, Baxter J, Broadus A, Frohman L, eds. Endocrinology and metabolism. 2nd ed. New York: McGraw-Hill, 1987:671–92.
21. Foster KG, Ginsburg J, Weiner JS. Role of circulating catecholamines in human eccrine sweat gland control. Clin Sci 1970; 39: 823–32.
22. Allen JA, Roddie IC. The role of circulating catecholamines in sweat production in man. J Physiol 1972; 227: 801–14.
23. Corrall RJM, Frier BM, Davidson NM, Hopkins WM, French EB. Cholinergic manifestations of the acute autonomic reaction to hypoglycaemia in man. Clin Sci 1983; 64: 49–53.
24. Shah SD, Tse TF, Clutter WE, Cryer PE. The human sympathochromaffin system. Am J Physiol 1984; 247: E380–E384.
25. Marks V, Marrack D, Rose FC. Hyperinsulinism in the pathogenesis of neuroglycopenic syndromes. Proc R Soc Med 1961; 54: 747–9.
26. Holmes CS, Hayford JT, Gonzalez JL, Weydert JA. A survey of cognitive functioning at different glucose levels in diabetic persons. Diabetes Care 1983; 6: 180–5.
27. Herold KC, Polonsky KS, Cohen RM, Levy J, Douglas F. Variable deterioration in cortical function during insulin-induced hypoglycemia. Diabetes 1985; 34: 677–85.
28. Pramming S, Thorsteinsson B, Theilgaard A, Pinner EM, Binder C. Cognitive function during hypoglycaemia in type I diabetes mellitus. Br Med J 1986; 292: 647–50.
29. Gjedde A, Crone C. Blood–brain glucose transfer: repression in chronic hyperglycemia. Science 1981; 214: 456–7.
30. McCall AL, Millington WR, Wurtman RJ. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus. Proc Natl Acad Sci USA 1982; 79: 5406–10.
31. McAll A, Sussman I, Carson M, Ruderman N. Glucose exposure of cultured microvascular endothelium regulates hexose transport but not growth. Diabetes 1987; 36: 23A. abstract.
32. Matthaei S, Horuk R, Olefsky JM. Blood–brain glucose transfer in diabetes mellitus: decreased number of glucose transporters at blood–brain barrier. Diabetes 1986; 35: 1181–4.
33. Brooks DJ, Gibbs JSR, Sharp P, et al. Regional cerebral glucose transport in insulin-dependent diabetic patients studied using [11c]3–0-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab 1986; 6: 240–4.
34. Grill V, Gutniak M, Blomqvist G, Stone-Elander S, Widen L. Decreased cerebral metabolic rate of glucose (CMRgl) in IDDM: studies with positron emission tomography (PET). Diabetes 1987; 36: 14A. abstract.
35. Cryer PE. Hypoglycemia and insulin dependent diabetes mellitus. In: Alberti KGMM, Krall LP, eds. The diabetes annual. Vol. 4. Amsterdam: Elsevier (in press).