Oxygen Dependent Regulation of DNA Synthesis and Growth of Ehrlich Ascites Tumor Cells in Vitro and in Vivo

Cancer Research

Volumn 48, Issue 8, 1988, Pages 2053-2060

  Probst, Hans ^a   Gekeler, Volker ^a   Schiffer, Helmut ^a   Klenzle Pfeilsticker, Hildegard ^a   Stropp, Udo ^a   Sttzer, Karl Eogen ^a   Frenzel Stötzer, Iris ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CELL CULTURE; DNA SYNTHESIS; EHRLICH ASCITES TUMOR; HYPOXIA; MOUSE; NONHUMAN;

ANIMAL; CARCINOMA, EHRLICH TUMOR; DNA; DNA REPLICATION; INTERPHASE; MICE; OXYGEN; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0023938135     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Acker, H., Carlsson, J., Durand, R., and Sutherland, R. M. (eds.). Spheroids in Cancer Research: Methods and Perspectives, Berlin: Springer Verlag, 1984.
2. Shrieve, D. C., Deen, D. F., and Harris, J. W. Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro. Cancer Res., 4:3521-3527,1983.
3. Pettersen, E. O., and Lindmo, T. Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia. Br. J. Cancer, 48: 809–817, 1983.
4. Rotlin, D., Robinson, B., and Tannock, F. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. Cancer Res., 46:2821-2826, 1986.
5. Kennedy, K. A., Teicher, B. A., Rockwell, S., and Sartorelli, A. C. The hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem. Pharmacol., 29:1-8,1980.
6. Spiro, I. J., Rice, G. C., Durand, R. E., Stinckler, R., and Ling, C. C. Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia. Int. J. Radiat. Oncol. Biol. Phys., 10:1275-1285,1984.
7. Song, C. W., Lee, I., Hasegawa, T., Rhee, J. G., and Levitt, S. H. Increase in PO2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen. Cancer Res., 47:442-446, 1987.
8. Probst, H., and Gekeler, V. Reversible inhibition of replicon initiation in Ehrlich ascites cells by anaerobiosis. Biochem. Biophys. Res. Commun., 94: 55-60,1980.
9. Probst, H., Gekeler, V., and Helftenbein, E. Oxygen dependence of nuclear DNA replication in Ehrlich ascites cells. Exp. Cell Res., 154:327-341,1984.
10. Hand, R. Eucaryotic DNA: organisation of the genome replication. Cell, 15: 317-325,1978.
11. Huberman, J. A. Eucaryotic DNA replication: a complex picture partially clarified. Cell, 48:7-8,1987.
12. Nakamura, H., Morita, T., and Sato, C. Structural organisations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp. Cell Res., 165: 291-297,1986.
13. Allison, D. C., Anderson, S., Ridolpho, P. F., Meyne, J., and Robertson, J. Alterations in the DNA metabolism of MCa-11 mouse mammary tumor cells grown in vivo and in vitro. Cancer Res., 46:3951-3957, 1986.
14. Nielsen, K., and Granzow, C. Chromosome band pattern of near tetraploid Ehrlich-Lettré mouse ascites cells (ELT Bonn) in vivo and in vitro. Hereditas, 98:95-103,1983.
15. Probst, H., and Maisenbacher, J. Use of zonal centrifugation for preparing synchronous cultures from Ehrlich ascites cells grown in vivo. Exp. Cell Res., 78:335-344, 1973.
16. Altmann, H. J. Bestimmung von in Wasser gelöstem Sauerstoff mit Leukob-erbellinblau I. Eine schnelle Winkler-Methode. Z. Anal. Chem., 262:97-99, 1972.
17. Probst, H., Hofstaetter, T., Jenke, H. S., Gentner, P., and Müller-Scholz, D. Metabolism and non-random occurrence of nonnascent short chains in the DNA of Ehrlich ascites cells. Biochim. Biophys. Acta, 740:200-211,1983.
18. Read, S. M., and Northcote, N. J. Minimization of variation in the response to different proteins of the Coomassie Blue G dye-binding assay for protein. Anal. Biochem., 116:53-64, 1981.
19. Probst, H., Hamprecht, K., and Gekeler, V. Replicon initiation frequency and intracellular levels of ATP, ADP, AMP and of diadenosine 5’,5’-P1 P4-tetraphosphate in Ehrlich ascites cells cultured aerobically and anaerobically. Biochem. Biophys. Res. Commun., 110:688-693, 1983.
20. Kaltenbach, J. P., Kaltenbach, M. H., and Lyons, B. Nigrosin as a dye for differentiating live and dead cells. Exp. Cell Res., 16:112-117, 1958.
21. Baker, D. J., and Town, C. D. “Anoxia” in radiobiology. Br. J. Radiol., 39: 706-707,1966.
22. Franko, A. J., Freedman, H. I., and Koch, C. J. Oxygen supply to spheroids in spinner and liquid-overlay culture. In: H. Acker, J. Carlsson, R. Durand, and R. M. Sutherland (eds.), Spheroids in Cancer Research: Methods and Perspectives, pp. 162–167. Berlin: Springer Verlag, 1984.
23. Chapman, J. D., Sturrock, J., Boag, J. W., and Crookall, J. O. Factors affecting the oxygen tension around cells growing in plastic Petri dishes. Int J. Radiat Biol., 17:305-328,1970.
24. Mueller-Klieser, W. F., and Sutherland, R. M. Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. Cancer Res., 42:237-242,1982.
25. Bedford, J. S., and Mitchell, J. B. The effect of hypoxia on the growth and radiation response of mammalian cells in culture. Br. J. Radiol., 47: 687-696,1974.
26. Jones, D. P. Renal metabolism during normoxia, hypoxia, and ischemic injury. Ann. Rev. Physiol., 48:33-50, 1986.
27. Hudson, H. M. The labelled mitosis curve for a population consisting of fast and slowly cycling cells. J. Theor. Biol., 66:63-79,1977.
28. Probst, H., Blütters, R., and Fielitz, J. DNA replication in asynchronous and synchronous Ehrlich ascites cells in different conditions of growth. Exp. Cell Res., 130:1-3,1980.
29. Hochhauser, S. J., Stein, J. L., and Stein, G. S. Gene expression and cell cycle regulation. Int Rev. Cytol., 71:95-243,1981.
30. Pettersen, E. O., and Lindmo, T. Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S. Br. J. Cancer, 43: 355–366, 1981.
31. Merz, R., and Schneider, F. Growth characteristics of in vitro cultured Ehrlich ascites tumor cells under anaerobic conditions and after reaeration. Z. Naturforsch. Sect. C Biosci., 37:326-334,1982.