Impaired polyglutamylation of methotrexate as a cause of resistance in ccrf-cem cells after short-term, high-dose treatment with this drug

Cancer Research

Volumn 48, Issue 8, 1988, Pages 2149-2155

  Pizzorno, Giuseppe ^a,b   Mini, Enrico ^a,b   Coronnello, Marcella ^a,b   McGuire, John J ^a,b   Moroson, Barbara A ^a,b   Cashmore, Arlene R ^a,b   Dreyer, Robert N ^b   Lin, James T ^b   Mazzei, Teresita ^b   Periti, Piero ^b   Bertino, Joseph R ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE; METHOTREXATE POLYGLUTAMATE; RADIOISOTOPE;

CELL CULTURE; DRUG METABOLISM; DRUG RESISTANCE; HUMAN; HUMAN CELL; LEUKEMIA CELL;

DRUG RESISTANCE; HUMAN; METHOTREXATE; PEPTIDES; POLYGLUTAMIC ACID; QUINAZOLINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETREXATE; TUMOR CELLS, CULTURED;

EID: 0023935785     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

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