Lewy bodies are ubiquitinated - A light and electron microscopic immunocytochemical study

Acta Neuropathologica

Volumn 75, Issue 4, 1988, Pages 345-353

  Kuzuhara, S ^a,b   Mori, H ^b   Izumiyama, N ^b   Yoshimura, M ^b   Ihara, Y ^b  

^a Tokyo Metropolitan Institute of Gerontology   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Immunocytochemistry; Lewy body; Paired helical filaments; Ubiquitin

Indexed keywords

MONOCLONAL ANTIBODY; UBIQUITIN;

HISTOCHEMISTRY; HISTOLOGY; HUMAN; HUMAN CELL; LEWY BODY; PAIRED HELICAL FILAMENT; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; BRAIN DISEASES; BRAIN STEM; CEREBRAL CORTEX; CYTOPLASMIC GRANULES; CYTOSKELETAL PROTEINS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; PARKINSON DISEASE; SUPPORT, NON-U.S. GOV'T;

EID: 0023931333     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/BF00687787     Document Type: Article

References (28)

1. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85
2. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy
3. Phase and electron microscopic observation of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease
4. The Lewy body in Parkinson's disease
5. Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys
6. Reaction of Lewy bodies with antibodies to phosphorylated and nonphosphorylated neurofilaments
7. Bodian's silver method stains neurofilament polypeptides
8. Lewy bodies of Parkinson's disease contain neurofilament antigens
9. Microtubule-associated protein tau, a component of Alzheimer paired helical filaments
10. Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology
11. The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates
12. Ubiquitin: roles in protein modification and breakdown
13. Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells
14. Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
15. Staining of Alzheimer's neurofibrillary tangles with antiserum against 200K component of neurofilament
16. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins
17. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease
18. Lewy bodies in cerebral cortex. Report of three cases
19. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree. A new disease?
20. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
21. High-molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain
22. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
23. Immunocytochemical study on senile plaques in Alzheimer's disease. I. Preparation of an anti-microtubule-associated proteins (MAPs) antiserum and its specificity
24. Immunocytochemical study on senile plaques in Alzheimer's disease. II. Abnormal dendrites in senile plaques as revealed by anti-microtubule-associated proteins (MAPs) immunostaining
25. One of the antigenic determinants of paired helical filaments is related to tau protein
26. MPTP: a neurotoxin relevant to the pathophysiology of Parkinson's disease. The 1985 George C. Cotzias lecture
27. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ
28. Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”