Effect of prednisolone and ketotifen on β2-adrenoceptors in asthmatic patients receiving β2-bronchodilators

European Journal of Clinical Pharmacology

Volumn 34, Issue 2, 1988, Pages 145-150

  Brodde, O E ^a   Howe, U ^a   Egerszegi, S ^b   Konietzko, N ^b   Michel, M C ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b RUHRLANDKLINIK   (Germany)

Author keywords

asthma; beta adrenoceptor desensitization; ketotifen; lymphocyte beta2 adrenoceptors; prednisolone; salbutamol; tachyphylaxis; terbutaline; theophylline

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BUDESONIDE; CROMOGLYCATE DISODIUM; CYCLIC AMP; KETOTIFEN; PREDNISOLONE; SALBUTAMOL; TERBUTALINE; THEOPHYLLINE;

ASTHMA; CLINICAL ARTICLE; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG FUNCTION; LYMPHOCYTE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; ADULT; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; CYCLIC AMP; FEMALE; HUMAN; ISOPROTERENOL; KETOTIFEN; LYMPHOCYTES; MALE; MIDDLE AGE; PEAK EXPIRATORY FLOW RATE; PREDNISOLONE; RECEPTORS, ADRENERGIC, BETA; RESPIRATORY FUNCTION TESTS; SUPPORT, NON-U.S. GOV'T;

EID: 0023930861     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/BF00614551     Document Type: Article

References (38)

1. Bronchodilator drugs
2. Adrenergic therapy of bronchial asthma
3. Agonist-induced desensitization of the β-adrenergic receptor-linked adenylate cyclase
4. β-Adrenergic receptors: Biochemical mechanisms of physiological regulation
5. Whither beta-adrenergic tachyphylaxis?
6. Tachyphylaxis to β-adrenoceptor agonists in human bronchial smooth muscle: studies in vitro
7. Desensitization of isolated human bronchial smooth muscle to β-receptor agonists
8. Spontaneous and provoked resistance to isoproterenol in isolated human bronchi
9. Adrenergic receptors in man. Direct identification, physiologic regulation and clinical alterations
10. Sbusensitization of beta-adrenoceptors in airways and lymphocytes of healthy and asthmatic subjects
11. Reversal of human lymphocyte β-adrenoceptor desensitization by glucocorticoids
12. Hydrocortisone-induced reversal of beta-adrenergic receptor uncoupling
13. Terbutaline-induced desensitization of human lymphocyte β2-adrenoceptors. Accelerated restoration of β-adrenoceptor responsiveness by prednisone and ketotifen
14. Isolation of mononuclear cells and granulocytes from human blood
15. A protein binding assay for adenosine 3′, 5′-cyclic monophosphate
16. The attraction of proteins for small molecules and ions
17. Different mechanisms underlying reduced β2-adrenoceptor responsiveness in lymphocytes from neonates and old subjects
18. The beta-adrenergic theory of the atopic abnormality in bronchial asthma
19. Human lymphocyte beta-adrenergic receptors are unaltered with age
20. High affinity beta2-adrenergic receptors in mononuclear leukocytes: Similar density in young and old normal subjects
21. The influence of sex, age, blood pressure and physical stress on β2-adrenoceptor density in mononuclear cells
22. Human β-adrenoceptors: Relation of myocardial and lymphocyte β-adrenoceptor density
23. Cardiac beta-adrenergic receptors
24. Lymphocyte beta2-adrenoceptors mirror precisely beta2-adrenoceptor, but poorly beta1-adrenoceptor changes in the human heart
25. The American Academy of Allergy and Immunology (Chairman: Sly RM)
26. Studies in vivo and in vitro of terbutaline-induced β-adrenoceptor desensitization in healthy subjects
27. In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, β-adrenoceptor agonists and theophylline
28. β-Adrenergic tachyphylaxis in the rat and its reversal and prevention by ketotifen
29. A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma
30. Ketotifen in adult asthma
31. Clinical evaluation of a new orally active anti-anaphylactic compound: Ketotifen (HC 20–511) in Japanese adult asthmatics
32. A steroid sparing effect of ketotifen in steroid-dependent asthmatics
33. Le ketotifen dans le traitement preventif de l'asthme
34. Histamine release in vitro: Inhibition by catecholamines and methylxanthines
35. A sequence of biochemical events in the antigen-induced release of chemical mediators from sensitized human lung tissue
36. Characterization of the receptor mediating the anti-anaphylactic effects of β-adrenoceptor agonists in human lung tissue in vitro
37. Sustained inhibition of antigen-induced histamine release from human lung by the β2-adrenoceptor agonist terbutaline