Molecular mechanisms for the hypoxiadependent activation of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233)

Biochemical Pharmacology

Volumn 37, Issue 8, 1988, Pages 1487-1495

  Laderoute, Keith ^a   Wardman, Peter ^b   Rauth, A Michael ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RADIOISOTOPE; TIRAPAZAMINE; XANTHINE OXIDASE;

CYTOTOXICITY; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIC CELL; NONHUMAN; PLASMID; PULSE RADIOLYSIS; RADIATION; REDUCTION;

CARBON DIOXIDE; DNA, BACTERIAL; ELECTRONS; FREE RADICALS; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; OXIDATION-REDUCTION; OXYGEN; PLASMIDS; TRIAZINES; XANTHINE OXIDASE;

EID: 0023929181     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(88)90010-X     Document Type: Article

References (31)

1. Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide
2. THE PREPARATION OF CYANAMIDE, UREA, AND RELATED COMPOUNDS LABELED WITH LONG-LIVED RADIOACTIVE CARBON
3. CHARACTERIZATION OF THE RED PIGMENT FORMED IN THE 2-THIOBARBITURIC ACID DETERMINATION OF OXIDATIVE RANCIDITYb
4. STRONGLY BASIC SYSTEMS: III. THEH−FUNCTION FOR VARIOUS SOLVENT SYSTEMS
5. REEVALUATION OF THE SPECTRAL AND KINETIC PROPERTIES OF HO2AND O2-FREE RADICALS
6. Radiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects