T-Cell Lymphomas Containing Epstein–Barr Viral DNA in Patients with Chronic Epstein–Barr Virus Infections

New England Journal of Medicine

Volumn 318, Issue 12, 1988, Pages 733-741

  Jones, James F ^a,b,c,d,e   Shurin, Susan ^a,b,c,d,e   Abramowsky, Carlos ^a,b,c,d,e   Tubbs, Raymond R ^a,b,c,d,e   Sciotto, Cosimo G ^a,b,c,d,e   Wahl, Raymond ^a,b,c,d,e   Sands, Julie ^a,b,c,d,e   Gottman, Dirk ^a,b,c,d,e   Katz, Ben Z ^a,b,c,d,e   Sklar, Jeffrey ^a,b,c,d,e  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Penrose Hospital   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIBIOTIC AGENT; CYCLOPHOSPHAMIDE; DNA; METHOTREXATE; PREDNISONE; VINCRISTINE;

CASE REPORT; EPSTEIN BARR VIRUS; HISTOCHEMISTRY; HUMAN; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; T CELL LYMPHOMA;

ADULT; ANTIBODIES, VIRAL; CASE REPORT; CHILD, PRESCHOOL; DNA, NEOPLASM; DNA, VIRAL; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMAN; LYMPHOMA; MALE; MIDDLE AGE; PHENOTYPE; T-LYMPHOCYTES;

EID: 0023928446     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198803243181203     Document Type: Article

References (48)

1. Epstein MA, Achong BG, eds. The Epstein-Ban virus. Berlin: Springer-Verlag, 1979:1–22.
2. Shearer WT, Ritz J, Finegold MJ, et al. Epstein-Ban” virus-associated Bcell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N Engl J Med 1985; 312: 1151–9.
3. Hanto DW, Sakamoto K, Purtilo DT, Simmons RL, Najarian JS. The Epstein–Barr vims in the pathogenesis of posttransplam lymphoproliferative disorders: clinical, pathologic, and virologic correlation. Surgery 1981; 90: 204–13.
4. Leyvraz S, Henle W, Chahinian AP, et al. Association of Epstein-Ban virus with thymic carcinoma. N Engl J Med 1985; 312: 1296–9.
5. Andiman W, Gradoville L, Heston L, et al. Use of cloned probes to detect Epstein–Barr viral DNA in tissues of patients with neoplastic and lymphoproliferative diseases. J Infect Dis 1983; 148: 967–77.
6. Schooley RT, Densen P, Harman D, et al. Antineutrophil antibodies in infectious mononucleosis. Am J Med 1984; 76: 85–90.
7. Lederman HM, Yolken R, D'Souza BJ, Winkelstein JA. Chronic disseminated Epstein–Barr virus infection and humoral immunodeficiency: detection of viral antigen by ELISA inhibition assay. Pediatr Infect Dis 1983; 2: 388–90.
8. Pagano JS, Shaw JE. Molecular probes and genomology. In: Epstein MA, Achong BG, eds. The Epstein-Ban virus. Berlin: Springer-Verlag, 1979:109–46.
9. Sixbey JW, Nedrud JG, Raab-Traub N, Hanes RA, Pagano JS. Epstein–Barr virus replication in oropharyngeal epithelial cells. N Engl J Med 1984; 310: 1225–30.
10. Wolf H, Haus M, Wilmes E. Persistence of Epstein-Ban vims in the parotid gland. J Virol 1984; 51: 795–8.
11. Tosato G, Blaese RM. Epstein–Barr virus infection and immunoregulation in man. Adv Immunol 1985; 37: 99–149.
12. Croce CM, Nowell PC. Molecular genetics of human B cell neoplasia. Adv Immunol 1986; 38: 245–74.
13. Tobi M, Straus SE. Chronic Epstein-Ban vims disease: a workshop held by the National Institute of Allergy and Infectious Diseases. Ann Intent Med 1985; 103: 951–3.
14. Jones JF, Ray CG, Minnich LL, Hicks MJ, Kibler R, Lucas DO. Evidence for active Epstein-Ban vims infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med 1985; 102: 1–7.
15. Sheibani K, Tubbs RR. Enzyme immunohistochemistry: technical aspects. Semin Diagn Pathol 1984; 1: 235–50.
16. Epstein AL, Marder RJ, Winter JN, Fox Rl. Two new monoclonal antibodies (LN-1, LN-2) reactive with B5 formalin-fixed, paraffin-embedded tissues with follicular and mantle zone human B lymphocytes and derived tumors. J Immunol 1984; 133: 1028–36.
17. Linder J, Ye YL, Harrington DS, Armitage JO, Weisenberger DD. Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue. Am J Pathol 1987; 127: 1–8.
18. Fingeroth JD, Weis JJ, Tedder RF, Strominger JL, Biro PA, Fearon DT. Epstein–Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA 1984; 81: 4510–4.
19. Fischer DK, Miller G, Gradoville L, et al. Genome of a mononucleosis Epstein–Barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates. Cell 1981; 24: 543–53.
20. Raab-Traub N, Flynn K. The structure of the termini of the Epstein–Barr virus as a marker of clonal cellular proliferation. Cell 1986; 47: 883–9.
21. Aisenberg achéal, Krontiris TG, Mak TW, Wilkes BM. Rearrangement of the gene for the beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders. N Engl] Med 1985; 313: 529–33.
22. Cleary ML, Chao J, Wamke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci USA 1984; 81: 593–7.
23. Sklar J, Cleary ML, Thielemans K, Gralow J, Wamke R, Levy R. Biclonal B-cell lymphoma. N Engl J Med 1984; 311: 20–7.
24. Weiss LM, Wood GS, Ellisen LW, Reynolds TC, Sklar J. Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease). Am J Pathol 1987; 126: 417–21.
25. Weiss LM, Wood GS, Trela M, Warnke RA, Sklar J. Clonal T-cell populations in lymphomatoid papulosis: evidence of a lymphoproliferative origin for a clinically benign disease. N Engl J Med 1986; 315: 475–9.
26. Siegelman MH, Cleary ML, Wamke R, Sklar J. Frequent biclonality and Ig gene alterations among B cell lymphomas that show multiple histologic forms. J Exp Med 1985; 161: 850–63.
27. Mullins JI, Rubsamen H, Franchini G, Wong-Staal F, Gallo RC. HTLV-Iuk: molecular cloning and analysis of proviral and flanking-sequence DNA from a cell line derived from a patient with peripheral T-cell lymphoma. In: Gallo RC, Essex ME, Gross L, eds. Human T-cell leukemia/lymphoma virus. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, 1984:157–66.
28. Brigati DJ, Myerson D, Leary JJ, et al. Detection of viral genomes and cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes. Virology 1983; 126: 32–50.
29. Haase A, Brahic M, Stowring L, Blum H. Detection of viral nucleic acids by in situ hybridization probes. Methods Virol 1984; 7: 189–226.
30. Grogan TM, Fielder K, Rangel C, et al. Peripheral T-cell lymphoma: aggressive disease with heterogeneous immunotypes. Am J Clin Pathol 1985; 83: 279–88.
31. Haynes BF. Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. In: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, eds. Leukocyte typing II. Vol. 1. New York: Springer-Verlag, 1986: 3–30.
32. Reinherz EL, Morimoto C, Fitzgerald KA, Hussey RE, Daley JF, Schlossman SF. Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J Immunol 1982; 128: 463–8.
33. Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J. Epstein–Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol 1987; 129: 86–91.
34. Skare J, Edson C, Farley J, Strominger JL. The B95–8 isolate of Epstein–Barr virus arose from an isolate with a standard genome. J Virol 1982; 44: 1088–91.
35. Stevenson M, Volsky B, Hedenskog M, Volsky DJ. Immortalization of human T lymphocytes after transfection of Epstein–Barr virus DNA. Science 1986; 233: 980–4.
36. Alfieri C, Ghibu F, Joncas JH. Lytic, nontransforming Epstein–Barr virus (EBV) from a patient with chronic active EBV infection. Can Med Assoc J 1984; 131: 1249–52.
37. Miller G, Grogan E, Fischer DK, et al. Antibody responses to two Epstein–Barr virus nuclear antigens defined by gene transfer. N Engl J Med 1985; 312: 750–5.
38. Edson CM, Cohen LK, Henle W, Strominger JL. An unusually high-titer human anti-Epstein Barr virus (EBV) serum and its use in the study of EBVspecific proteins synthesized in vitro and in vivo. J Immunol 1983; 130: 919–24.
39. Schooley RT, Carey RW, Miller G, et al. Chronic Epstein–Barr virus infection associated with fever and interstitial pneumonitis: clinical and serologic features and response to antiviral chemotherapy. Ann Intern Med 1986; 104: 636–43.
40. Purtilo DT, Szymanski I, Bhaman J, et al. Epstein–Barr virus infection in the X-linked recessive lymphoproliferative syndrome. Lancet 1978; 1: 798–801.
41. Sato T. Acute Epstein–Barr virus infection and diffuse large-cell lymphoma. J Infect 1985; 10: 265–7.
42. Masucci MG, Szigeti R, Ernberg I, et al. Cell-mediated immune reactions in three patients with malignant lymphoproliferative diseases in remission and abnormally high Epstein–Barr virus antibody titers. Cancer Res 1981; 41: 4292–301.
43. Ten Napel CHH, The TH, Van Egten-Bijker J, Degast GCD, Halie MR, Langanhuysen MMAC. Discordance of Epstein–Barr virus (EBV) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titers and lowered in vitro lymphocyte reactivity. Clin Exp Immunol 1978; 34: 338–46.
44. Shore A, Dosch H-M, Gelfand EW. Expression and modulation of C3 receptors during early T-cell ontogeny. Cell Immunol 1979; 45: 157–6.
45. Smith SH, Brown MH, Rowe D, Callard RE, Beverely PCL. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL 1. Immunology 1986; 58: 63–70.
46. Knowles DM II. The human T-cell leukemias: clinical, cytomorphologic, immunophenotypic, and genotypic characteristics. Hum Pathol 1986; 17: 14–33.
47. Meuer SC, Cooper DA, Hodgdon JC, et al. Immunoregulatory human T lymphocytes triggered as a consequence of viral infection: clonal analysis of helper, suppressor inducer and suppressor effector cell populations. J Immunol 1983; 131: 1167–72.
48. Miller G, Shope T, Lisco H, Stitt D, Lipman M. Epstein-Ban virus: transformation, cytopathic changes, and viral antigens in squinel monkey and marmoset leukocytes. Proc Natl Acad Sci USA 1972; 69: 383–7.