Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function

Biochemical Pharmacology

Volumn 37, Issue 13, 1988, Pages 2495-2501

  Moncada, Salvador ^a   Radomski, Marek W ^a   Palmer, Richard M J ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PROSTACYCLIN;

ENDOTHELIUM; HUMAN; HUMAN CELL; THROMBOCYTE;

ANIMAL; BIOLOGICAL PRODUCTS; BLOOD PLATELETS; ENDOTHELIUM, VASCULAR; HUMAN; NITRIC OXIDE;

EID: 0023928184     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(88)90236-5     Document Type: Article

References (60)

1. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
2. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
3. The release and fate of vasoactive hormones in the circulation
4. Prostacycli—discovery and biological importance
5. Prostacyclin and endothelium-derived relaxing factor: biological interactions and significance
6. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium
7. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium
8. The role of endothelium in the responses of vascular smooth muscle to drugs
9. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
10. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
11. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta
12. Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells
13. Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets
14. Mechanism of action of some inhibitors of endothelium-derived relaxing factor
15. Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture
16. The nature of endothelium-derived vascular relaxant factor
17. The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide or bovine retractor penis inhibitory factor
18. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin
19. The generation of Superoxide radical during the autooxidation of hemoglobin
20. Comparative pharmacology of EDRF and nitric oxide on vascular strips
21. Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta
22. Endothelium-dependent vasodilation by melittin: are lipoxygenase products involved?
23. A phorbol ester inhibits the release of endothelium-derived relaxing factor
24. Endothelial cells as mediators of vasodilation of arteries
25. Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells
26. Inhibitors of acyl-coenzyme A: lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor
27. Turnover of inositol phospholipids and signal transduction
28. Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides
29. Induction of prostacyclin biosyn-thesis is closely associated with increased guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium
30. Nitric oxide release accounts for the biological activity of endo-thelium-derived relaxing factor
31. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
32. Progress in autophannacology. A survey of present knowledge of the chemical regulation of certain functions by natural constituents of the tissues
33. Reaction of Superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution
34. A comparison between the rate of reaction of nitric oxide in the gas phase and in whole cigarette smoke
35. Stabilization and partial characterization of endothelium derived relaxing factor from cultured bovine ortic endothelial cells
36. Endothelium-derived relaxing factor released from cultured cells; differentiation from nitric oxide
37. Endothelium-derived relaxing factor is a selective relaxant of vascular smooth muscle
38. Anion exchange resins discriminate between nitric oxide and EDRF
39. Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP)
40. The end of the quest?
41. Single stretchactivated ion channels in vascular endothelial cells as mechanotransducers?
42. The effect of low-density lipoproteins on the synthesis of cyclic nucleotides induced by prostacyclin in isolated platelets
43. Effect of forskolin on the maintenance of platelet properties during storage
44. Endothelium-dependent and independent relaxation of aortic rings from hypertensive rats
45. The loss of endothelium-dependent vascular relaxation in hypertension
46. Effect of hypercholesterolemia on vascular reactivity in the rabbit: 1: Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits
47. Paradoxical vaso-constriction induced by acetylcholine in atherosclerotic coronary arteries
48. Properties and mechanisms of production and action of endothelium-derived relaxing factor
49. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta
50. Evidence that the inactivated form of inhibitory factor extracted from bovine retractor penis is nitrite and the acid-activated form is nitric oxide
51. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopoly-saccharaide
52. Macrophage cytotoxicity: role for l-arginine deiminase and imino nitrogen oxidation to nitrite
53. Evidence for the role of endothelium-derived relaxing factor in acetycholine-induced vasodilatation in the intact lung
54. The effect of nitric oxide on the isolated perfused rabbit heart
55. The role of endothelium in the control of vascular tone