Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

The Journal of Pathology

Volumn 155, Issue 1, 1988, Pages 9-15

  Lowe, James ^a   Blanchard, Andrew ^b   Morrell, Ken ^a   Lennox, Graham ^a   Reynolds, Lindsay ^b   Billett, Michael ^b   Landon, Michael ^b   Mayer, R John ^b  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

astrocytes; dementia; immunohistochemistry; intermediate filaments; liver disease; Parkinson's disease; protein catabolism; Ubiquitin

Indexed keywords

UBIQUITIN;

ASTROCYTE; ASTROCYTOMA; ETIOLOGY; HISTOCHEMISTRY; HISTOLOGY; HUMAN; HUMAN CELL; INTERMEDIATE FILAMENT; LIVER DISEASE; MALLORY BODY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; ASTROCYTOMA; BRAIN; BRAIN DISEASES; CEREBELLAR NEOPLASMS; CYTOSKELETON; DEMENTIA; HUMAN; INCLUSION BODIES; INTERMEDIATE FILAMENTS; LIVER DISEASES, ALCOHOLIC; MUSCLES; PARKINSON DISEASE; UBIQUITINS;

EID: 0023927981     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711550105     Document Type: Article

References (35)

1. Ubiquitin mediated pathways for intracellular proteolysis
2. Ubiquitin is a heat shock protein in chicken embryo fibroblasts
3. Proposed role of ATP in protein breakdown: conjugation of proteins with the multiple chains of the polypeptide of ATP‐dependent proteolysis
4. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85
5. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
6. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
7. The isolation and identification of ubiquitin from the high mobility group (HMG) non‐histone protein fraction
8. The immunocytochemical detection and quantitation of intracellular ubiquitin–protein conjugates
9. Idiopathic Parkinson's disease and the Lewy body disorders
10. Dementia and Parkinson's disease associated with diffuse cortical Lewy bodies
11. Reaction of Lewy bodies with antibodies to phosphorylated and non‐phosphorylated neurofilaments
12. Atypical senile dementia with widespread Lewy type inclusions in the cerebral cortex
13. Lewy body dimentia without Alzheimer changes
14. Present understanding of the development of Mallory's body
15. Mallory bodies—immunocytochemical detection by antisera to unique non‐prekeratin components
16. Morphologic variants of alcoholic hyaline
17. Immunocytochemistry of cerebellar astrocytomas with a special note on Rosenthal fibres
18. A note on the nature of eosinophilic granular bodies in astrocytic gliomas
19. The cytoplasmic bodies in a congenital myopathy can be stained with antibodies to desmin, the muscle‐specific intermediate filament protein
20. Cytoplasmic body neuromyopathy presenting with respiratory failure and weight loss
21. Classic and generalised variants of Pick's disease: a clinico‐pathological, ultrastructural, and immunocytochemical comparative study
22. The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies, and ‘rod‐like’ structures as seen in Guam amyotrophic lateral sclerosis and Parkinsonism–dementia complex
23. The ubiquitin system: functions and mechanisms
24. The yeast ubiquitin genes: a family of natural fusion genes
25. Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesised as a precursor
26. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses
27. Two monoclonal antibodies recognise Alzheimer's neurofibrillary tangles, neurofilaments, and microtubule associated proteins
28. A putative protein‐sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with micro‐injected purified glycolytic enzymes in cells
29. A putative protein‐sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with transplanted Sendai‐viral envelope proteins in HTC cells
30. Intracellular protein catabolism: state of the art
31. The dynamic state of heat shock proteins in chicken embryo fibroblasts
32. Locus coeruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys