Impaired Glucose Tolerance as a Disorder of Insulin Action

New England Journal of Medicine

Volumn 318, Issue 19, 1988, Pages 1217-1225

  Lillioja, Stephen ^a   Mott, David M ^a   Howard, Barbara V ^a   Bennett, Peter H ^a   Yki Järvinen, Hannele ^a   Freymond, Daniel ^a   Nyomba, Bulangu L ^a   Zurlo, Francesco ^a   Swinburn, Boyd ^a   Bogardus, Clifton ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS;

ADULT; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; INDIANS, NORTH AMERICAN; INSULIN; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE;

EID: 0023924773     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198805123181901     Document Type: Article

References (65)

1. Diabetes mellitus: report of a WHO Study Group. World Health Organization technical report series. No. 727. Geneva: World Health Organization, 1985.
2. Bennett PH. The diagnosis of diabetes: new international classification and diagnostic criteria. Annu Rev Med 1983; 34: 295–309.
3. Rushforth NB, Bennett PH, Steinberg AG, Miller M. Comparison of the value of the two- and one-hour glucose levels of the oral GTT in the diagnosis of diabetes in Pima Indians. Diabetes 1975; 24: 538–46.
4. Zimmet P, Whitehouse S. Bimodality of fasting and two-hour glucose tolerance distributions in a Micronesian population. Diabetes 1978; 27: 793–800.
5. Raper LR, Taylor R, Zimmet P, Milne B, Balkau B. Bimodality in glucose tolerance distributions in the urban Polynesian population of Western Samoa. Diabetes Res 1984; 1: 19–26.
6. Rosenthal M, McMahan CA, Stern MP, et al. Evidence of bimodality of two hour plasma glucose concentrations in Mexican Americans: results from the San Antonio Heart Study. J Chronic Dis 1985; 38: 5–16.
7. Jarrett RJ, Keen H. Hyperglycæmia and diabetes mellitus. Lancet 1976; 2: 1009–12.
8. Al Sayegh H, Jarrett RJ. Oral glucose-tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall survey. Lancet 1979; 2: 431–3.
9. Pettitt DJ, Knowler WC, Lisse JR, Bennett PH. Development of retinopathy and proteinuria in relation to plasma-glucose concentrations in Pima Indians. Lancet 1980; 2: 1050–2.
10. Rushforth NB, Miller M, Bennett PH. Fasting and two-hour post-load glucose levels for the diagnosis of diabetes: the relationship between glucose levels and complications of diabetes in the Pima Indians. Diabetologia 1979; 16: 373–9.
11. Harris MI, Hadden WC, Knowler WC, Bennett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20–74 years. Diabetes 1987; 36: 523–34.
12. Stern MP. Type II diabetes mellitus: interface between clinical and epidemiological investigation. Diabetes Care 1988; 11: 119–26.
13. Keen H, Jarrett RJ, McCartney P. The ten-year follow-up of the Bedford Survey (1962–1972): glucose tolerance and diabetes. Diabetologia 1982; 22: 73–8.
14. King H, Zimmet P, Raper LR, Balkau B. The natural history of impaired glucose tolerance in the Micronesian population of Nauru: a six-year follow-up study. Diabetologia 1984; 26: 39–43.
15. Knowler WC, Pettitt DJ, Everhart JE, Slaine KS, Bennett PH, Mott D. Rate of deterioration of impaired glucose tolerance to diabetes and the effects of age, obesity and serum insulin. Diabetologia 1986; 29: 558A. abstract.
16. Lillioja S, Mott DM, Zawadzki JK, et al. In vivo insulin action is familial characteristic in nondiabetic Pima Indians. Diabetes 1987; 36: 1329–35.
17. Goldman RF, Buskirk ER. Body volume measurement by underwater weighing. In: Brožek J, Henschel A, eds. Techniques for measuring body composition. Washington, D.C.: National Academy of Sciences, National Research Council, 1961:78–106.
18. Keys A, Brožek J. Body fat in adult man. Physiol Rev 1953; 33: 245–325.
19. Simpson RG, Benedetti A, Grodsky GM, Karam JH, Forsham PH. Early phase of insulin release. Diabetes 1968; 17: 684–92.
20. Chen M, Porte D Jr. The effect of rate and dose of glucose infusion on the acute insulin response in man. J Clin Endocrinol Metab 1976; 42: 1168–75.
21. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214–E223.
22. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 1959; 82: 420–30.
23. Best JD, Taborsky GT Jr, Halter JB, Porte D Jr. Glucose disposal is not proportional to plasma glucose level in man. Diabetes 1981; 30: 847–50.
24. SAS user's guide: statistics: version 5. Rev. ed. Cary, N.C.: SAS Institute, 1985:10, 797.
25. Lillioja S, Young AA, Cutler CL, et al. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest 1987; 80: 415–24.
26. Reaven G, Miller R. Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes 1968; 17: 560–9.
27. Welborn TA, Stenhouse NS, Johnstone CG. Factors determining serum-insulin response in a population sample. Diabetologia 1969; 5: 263–6.
28. Savage PJ, Dippe SE, Bennett PH, et al. Hyperinsulinemia and hypoinsulinemia: insulin responses to oral carbohydrate over a wide spectrum of glucose tolerance. Diabetes 1975; 24: 362–8.
29. Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest 1984; 74: 1238–46.
30. Knowler WC, Slaine KR, Everhart JE, Bennett PH. Variation in insulin responses to oral glucose: subclassification of NIDDM or national history of one disease? Diabetes 1986; 35: Suppl 1: 129A. abstract.
31. Hansen BC, Bodkin NL. Heterogeneity of insulin responses: phases leading to Type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey. Diabetologia 1986; 29: 713–9.
32. Polonsky KS, Given BD, Hirsch L, et al. Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 1988; 81: 435–41.
33. Polonsky KS, Given BD, Van Cauter E. Twenty-four–hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 1988; 81: 442–8.
34. Ward WK, Bolgiano DC, McKnight B, Halter JB, Porte D Jr. Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 1984; 74: 1318–28.
35. Halter JB, Graf RJ, Porte D Jr. Potentiation of insulin secretory responses by plasma glucose levels in man: evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation. J Clin Endocrinol Metab 1979; 48: 946–54.
36. Goodner CJ, Conway MJ, Werrbach JH. Control of insulin secretion during fasting hyperglycemia in adult diabetics and in nondiabetic subjects during infusion of glucose. J Clin Invest 1969; 48: 1878–87.
37. Beck P, Schalch DS, Parker ML, Kipnis DM, Daughaday WH. Correlative studies of growth hormone and insulin plasma concentrations with metabolic abnormalities in acromegaly. J Lab Clin Med 1965; 66: 366–79.
38. Roelfsema F, Frölich M. Glucose tolerance and plasma immunoreactive insulin levels in acromegalics before and after selective transsphenoidal surgery. Clin Endocrinol (Oxf) 1985; 22: 531–7.
39. Sherwin RS, Schulman GA, Hendler R, Walesky M, Belous A, Tamborlane W. Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man. Diabetologia 1983; 24: 155–61.
40. Cohen JC, Hickman R. Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids. J Clin Endocrinol Metab 1987; 64: 960–3.
41. Drenick EJ, Brickman AS, Gold EM. Dissociation of the obesity–hyperinsulinism relationship following dietary restriction and hyperalimentation. Am J Clin Nutr 1972; 25: 746–55.
42. Horton ES, Danforth E Jr, Sims EAH, Salans LB. Endocrine and metabolic alterations in spontaneous and experimental obesity. In: Bray GA, ed. Obesity in perspective: a conference sponsored by the John E. Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, Bethesda, Maryland, October 1–3, 1973. Washington, D.C: Government Printing Office, 1975:323–34. (DHEW publication no. 75–708.)
43. Frier BM, Corrall RJM, Adrian TE, Bloom SR, Strachan RK, Heading RC. The influence of adrenergic denervation on the response to feeding of the gastroenteropancreatic system in man. Clin Endocrinol (Oxf) 1984; 21: 639–47.
44. Rose HG, Yalow RS, Schweitzer P, Schwartz E. Insulin as a potential factor influencing blood pressure in amputees. Hypertension 1986; 8: 793–800.
45. Burghen GA, Givens JR, Kitabchi AE. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 1980; 50: 113–6.
46. Dunaif A, Hoffman AR, Scully RE, et al. Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. Obstet Gynecol 1985; 66: 545–52.
47. Kahn CR, Flier JS, Bar RS, et al. The syndromes of insulin resistance and acanthosis nigricans: insulin-receptor disorders in man. N Engl J Med 1976; 294: 739–45.
48. Savage PJ, Bennion LJ, Bennett PH. Normalization of insulin and glucagon secretion in ketosis-resistant diabetes mellitus with prolonged diet therapy. J Clin Endocrinol Metab 1979; 49: 830–3.
49. Ward WK, Halter JB, Beard JC, Porte D Jr. Adaptation of B and A cell function during prolonged glucose infusion in human subjects. Am J Physiol 1984; 246: E405–E411.
50. Beard JC, Ward WK, Halter JB, Wallum BJ, Porte D Jr. Relationship of islet function to insulin action in human obesity. J Clin Endocrinol Metab 1987; 65: 59–64.
51. Curry DL. Insulin secretory dynamics in response to slow-rise and square-wave stimuli. Am J Physiol 1971; 221: 324–8.
52. Srikanta S, Ganda OP, Jackson RA, et al. Pre-Type I (insulin-dependent) diabetes: common endocrinological course despite immunological and immunogenetic heterogeneity. Diabetologia 1984; 27: 146–8.
53. Warram JH, Martin BC, Gleason RE, Soeldner JS. Slow glucose removal rate but not insulin secretion predicts development of NIDDM in offspring of two NIDDM parents. Diabetes 1987; 36: Suppl 1: 14A. abstract.
54. Unger RH, Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 1985; 28: 119–21.
55. Seltzer HS, Harris VL. Exhaustion of insulogenic reserve in maturity-onset diabetic patients during prolonged and continuous hyperglycemic stress. Diabetes 1964; 13: 6–13.
56. Clark A, Brown E, King T, Vanhegan RI, Turner RC. Islet changes induced by hyperglycemia in rats: effect of insulin or chlorpropamide therapy. Diabetes 1982; 31: 319–25.
57. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 1983; 71: 1544–53.
58. Portha B, Picon L. Insulin treatment improves the spontaneous remission of neonatal streptozotocin diabetes in the rat. Diabetes 1982; 31: 165–9.
59. Bolaffi JL, Heldt A, Lewis LD, Grodsky GM. The third phase of in vitro insulin secretion: evidence for glucose insensitivity. Diabetes 1986; 35: 370–3.
60. Leahy JL, Cooper HE, Deal DA, Weir GC. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: a study in normal rats using chronic in vivo glucose infusion. J Clin Invest 1986; 77: 908–15.
61. Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 1987; 80: 1037–44.
62. Hidaka H, Nagulesparan M, Klimes I, et al. Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics. J Clin Endocrinol Metab 1982; 54: 217–22.
63. Savage PJ, Bennion LJ, Flock EV, et al. Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. J Clin Endocrinol Metab 1979; 48: 999–1007.
64. Ferner RE, Stephenson P, Alberti KGMM. Hyperglycemia impairs B-cell function in non-insulin-dependent diabetes. Diabetes 1987; 36: Suppl 1: 96A. abstract.
65. Groop L, Miettinen A, Groop P-H, Meri S, Koskimies S, Bottazzo GF. Organ-specific autoimmunity and HLA-DR as markers for β-cell destruction in patients with type II diabetes. Diabetes 1988; 37: 99–103.