Studies on Scavengers of Active Oxygen Species. 1. Synthesis and Biological Activity of 2-O-Alkylascorbic Acids

Journal of Medicinal Chemistry

Volumn 31, Issue 4, 1988, Pages 793-798

  Kato, Kaneyoshi ^a   Terao, Shinji ^a   Shimamoto, Norio ^a   Hirata, Minoru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; ASCORBIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; HEART ARRHYTHMIA; LIPID PEROXIDATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMAL; ARRHYTHMIA; ASCORBIC ACID; HEART RATE; LIGATION; LINOLEIC ACID; LINOLEIC ACIDS; LIPID PEROXIDES; MALE; MICELLES; OXYGEN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023923325     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00399a019     Document Type: Article

References (22)

1. (a) Hammond, B.; Kontos, H. A.; Hess, M. L. Can. J. Physiol. Pharmacol. 1985, 63, 173.
2. Fridovich, I. Annu. Rev. Pharmacol. Toxicol. 1983, 23, 239.
3. Burton, K. P.; McCord, J. M.; Ghai, G. Am. J. Physiol. 1984, 246, H776.
4. McCord, J. M. N. Engl. J. Med. 1985, 312, 159.
5. Clark, R. A.; Leidal, K. G.; Pearson, D. W.; Nauseef, W. M. J. Biol. Chem. 1987, 262, 4065.
6. Halliwell, B.; Gutteridge, J. M. Trends Biochem. Sci. (Pers. Ed.) 1986, 11, 372.
7. Youngman, R. Y. Trends Biochem. Sci. (Pers. Ed.) 1984, 9, 280.
8. Bromberg, Y.; Pick, E. J. Biol. Chem. 1985, 260, 13539.
9. Beckman, J. K.; Borowitz, S. M.; Burr, I. M. Biol. Chem. 1987, 262, 1479.
10. Lands, W. E. M., Kulmacz, R. J.; Marshall, P. J. Free Radicals in Biology; Academic: Orlando, 1984; Vol. VI, p 39.
11. Woodward, B.; Zakaria, M. N. J. Mol. Cell. Cardiol. 1985,17, 485.
12. Seib, P. A.; Tolbelt, B. M. Ascorbic Acid: Chemistry, Metabolism, and Uses; Advance in Chemical Series 200; American Chemical Society: Washington, DC, 1982.
13. Blaschke, E.; Hertting, G. Biochem. Pharmacol. 1971, 20,1363.
14. Koppel, G. A.; Barton, R. L.; Bewley, J. R.; Briggs, S. L.; Parton, J. W. Brit. UK Pat. Appl. 2114571 A, 24 Aug 1983.
15. Jackson, K. G. A.; Jones, J. K. N. Can. J. Chem. 1965, 43, 450.
16. Jung, M. E.; Shaw, T. J. J. Am. Chem. Soc. 1980, 102, 6304.
17. Jernow, J.; Blount, J.; Oliveto, E.; Perrotta, A.; Rosen, P.; Toome, V. Tetrahedron 1979, 35, 1483.
18. Blois, M. S. Nature (London) 1958, 181, 1199.
19. Ohkawa, H.; Ohishi, N.; Yagi, K. Anal. Biochem. 1979, 95, 551.
20. Kharasch, E. D.; Novak, R. F. J. Biol. Chem. 1985,260,10645.
21. Manning, A. S.; Coltart, D. J.; Hearse, D. J. Circ. Res. 1984, 55, 545.
22. Second Clinical Conference on Free Radicals in Kyoto, Sept 20, 1986.