Antinuclear antibodies: Diagnostic markers and clues to the basis of systemic autoimmunity

Pediatric Infectious Disease Journal

Volumn 7, Issue 5, 1988, Pages S3-S9

  Tan, Eng M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; AUTOANTIBODY; AUTOANTIGEN; DNA; DNA DIRECTED RNA POLYMERASE; DNA TOPOISOMERASE;

ANTIGEN SM; AUTOIMMUNE DISEASE; CENTROMERE; DERMATOMYOSITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; PRIORITY JOURNAL; SCLERODERMA; SHORT SURVEY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMAL; ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL COMPARTMENTATION; DNA; HUMAN; IMMUNOLOGIC TECHNIQUES; INDICATORS AND REAGENTS; LUPUS ERYTHEMATOSUS, SYSTEMIC; RNA; RNA SPLICING; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023920546     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Deicher HRG, Holman HR, Kunkel HG: The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus. J Exp Med 109:97-107,1959
2. Tan EM, Kunkel HG: Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 96:464-471,1966
3. Northway JD, Tan EM: Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence. Clin Immunol Immunopathol 1:140-154, 1972
4. Mattioli M, Reichlin M: Physical association of two nuclear antigens and mutual occurrence of their antibodies: The relationship of the Sm and RNA protein (Mo) systems in SLE sera. J Immunol 110:1318-1324, 1973
5. Willingham RC, Pastan I: An Atlas of Immunoflurescence in Culture CeUs. New York, Academic Press, 1985
6. Lerner MR, Steitz JA: Snurps and Scyrps. Cell 25:298-300,1981
7. Notman DD, Kurata N, Tan EM: Profiles of antinuclear antibodies in systemic rheumatic diseases. Ann Intern Med 83:464- 469,1975
8. Tan EM, Carr RI, Schur PH, et al: DNA and antibody to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 45:1732-1740, 1966
9. Stollar BD: Antibodies to DNA. CRC Crit Rev Biochem 20:1- 36,1986
10. Stollar BD, Levine L, Lehrer HI, et al: The antigenic determinants of denatured DNA reactive with lupus erythematosus serum. Proc Natl Acad Sci USA 48:874-880,1962
11. Fritzler MJ, Tan EM: Antibodies to histones in drug-induced and idiopathic lupus erythematosus. J Clin Invest 62:560-567, 1978
12. Kunkel HG, Holman HR, Deicher HRG: Multiple autoantibodies in cell constituents in systemic lupus erythematosus. Ciba Foundation Symposium on Cellular Aspects of Immunity. Basel, Ciba, 1960, pp 429-437
13. Rubin RL, Joslin FG, Tan EM: Specificity of anti-histone antibodies in systemic lupus erythematosus. Arthritis Rheum25:779-782,1982
14. Tan EM, Kunkel HG: Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 96:464-471,1966
15. Moore CL, Sharp PA: Site-specific polyadenylation in a cell- free reaction. Cell 36:581-591, 1984
16. Bozzoni I, Annesi F, Beccari E, et al: Splicing of Xenopus laevis ribosomal protein RNAs is inhibited in vivo by antisera to ribonucleoproteins containing U1 small nuclear RNA. J Mol Biol 180:1173-1178, 1984
17. Fradin A, Jove R, Hemenway C, et al: Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell 37:927-936,1984
18. Conner GE, Nelson D, Wiesniewolski R, et al: Protein antigens of the RNA-protein complexes detected by anti-Sm and anti- RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders. J Exp Med 156:1475-1486, 1982
19. Fisher DE, Conner GE, Reeves WH, et al: Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation. Proc Natl Acad Sci USA 80:6356-6361, 1983
20. Mattioli M, Reichlin M: Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera. J Immunol107:1281-1290,1971
21. Sharp GC, Irvin WS, Tan EM, et al: Mixed connective tissue disease: An apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148-159, 1972
22. Yamagata H, Harley JB, Reichlin M: Molecular properties of the Ro/SSA antigen and enzyme-linked immunosorbent assay for quantitation of antibody. J Clin Invest 74:625-633, 1984
23. Harmon CE, Deng J-S, Peebles CL, et al: The importance of tissue substrate in the SS-A/Ro antigen-antibody system. Arthritis Rheum 27:166-173, 1984
24. Lieu T-S, Jiang M, Steigerwald JS, et al: Identification of the SS-A/Ro intracellular antigen with autoimmune sera. J Immunol Methods 71:217-228,1984
25. Alspaugh MA, Talal N, Tan EM: Differentiation and characterization of autoantibodies and their antigens in Sjogren’s syndrome. Arthritis Rheum 19:216-222,1976
26. Mattioli M, Reichlin M: Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus. Arthritis Rheum 17:421-429,1974
27. Lerner MR, Boyle JA, Hardin JA, Steitz JA. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 211:400-402, 1981
28. Hendrick JP, Wolin SL, Rinke J, et al: Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: Further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells. J Mol Cell Biol 12:1138- 1149,1981
29. Francoeur AM, Mathews MB: Interaction between VA-RNA and the lupus antigen La: Formation of a ribonucleoprotein particle in vitro. Proc Natl Acad Sci USA 79:6772-6776,1982
30. Chan EKL, Francoeur AM, Tan EM: Epitopes, structural domains and asymmetry of amino acid residues in SS-B/La nuclear protein. J Immunol 136:3744-3749, 1986
31. Reddy R, Henning D, Tan EM, et al: Identification of a La protein binding site in a RNA polymerase III transcript (4.51 RNA). J Biol Chem 258:8352-8356, 1983
32. Mimori T, Akizuki M, Yamagata H, et al: Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-sclero- derma overlap. J Clin Invest 68:611-620, 1981
33. Francoeur AM, Peebles CL, Gomper PT, et al: Identification of Ki (Ku, p70/p80) autoantigens and analysis of anti-Ki autoantibody reactivity. J Immunol 136:1648-1653,1986
34. Reeves WH: Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J Exp Med 161:18-39,1985
35. Mimori T, Hardin JA: Mechanisms of interaction between Ku protein and DNA. J Biol Chem 261:10375-10379,1986
36. Elkon KB, Pamassa AP, Foster CL: Lupus autoantibodies target ribosomal P proteins. J Exp Med 162:459-471,1985
37. Francoeur AM, Peebles CL, Heckman KJ, et al: Identification of ribosomal protein autoantigens. J Immunol 135:2378-2384, 1985
38. Miyachi K, Fritzler MJ, Tan EM: Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121:2228-2234, 1978
39. Takasaki Y, Deng JS, Tan EM: A nuclear antigen associated with cell proliferation and blast transformation: Its distribution in synchronized cells. J Exp Med 154:1899-1909,1981
40. Bravo R, Fey SJ, Bellatin J, et al: Identification of a nuclear and of a cytoplasmic polypeptide whose relative proportions are sensitive to changes in the rate of cell proliferation. Exp Cell Res 136:311-317, 1981
41. Mathews MB, Bernstein RM, Franze BR Jr, et al: Identity of the proliferating cell nuclear antigen and cyclin. Nature309:374-376,1984
42. Takasaki Y, Fishwild D, Tan EM: Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera. J Exp Med 159:981-992,1984
43. Ogata K, Ogata Y, Nakamura RM, et al: Purification and N- terminal amino acid sequence of proliferating cell nuclear antigen (PCNA)/cyclin and development of ELISA for anti- PCNA antibodies. J Immunol 135:2623-2627, 1985
44. Takasaki Y, Robinson WA, Tan EM: Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J Natl Cancer Inst 73:655-661, 1984
45. Kurki P, Vanderlaan M, Dolbeare F, et al: Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res 166:209-219, 1986
46. Ogata K, Kurki P, Celis JE, et al: Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication. Exp Cell Res, in press, 1987
47. Brunei C, Sri-Widada J, Jeanteur P: snRNPs and scRNPs in eukaryotic cells. Progr Mol Subcell Biol 9:1-52,1985
48. Nishikai M, Reichlin M: Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis: Characterization of the Jo-1 antibody system. Arthritis Rheum 23:881-888,1980
49. Mathews MB, Bernstein RM: Myositis autoantibody inhibits histidyl-tRNA synthetase: A model for autoimmunity. Nature304:177-179,1983
50. Yang DCH, Dang CV, Arnett FC. Rat liver histidyl-tRNA synthetase: Purification and inhibition by the myositis-specific anti-Jo-1 autoantibody. Biochem Biophys Res Commun 120:15- 21,1984
51. Bernstein RM, Morgan SH, Chapman J, et al: Anti-Jo-1 antibody: A marker for myositis with interstitial lung disease. Br Med 289:151-152,1984
52. Mathews MB, Reichlin M, Hughes GR, et al: Anti-threonyl- tRNA synthetase, a second myositis-related autoantibody. J Exp Med 160:420-434, 1984
53. Bunn CC, Bernstein RM, Mathews MB: Autoantibodies against alanyl-tRNA synthetase and tRNA Ala co-exist and are associated with myositis. J Exp Med 163:1281-1291,1986
54. Targoff IN, Reichlin M: The association between Mi-2 antibodies and dermatomyositis. Arthritis Rheum 28:796-803, 1985
55. Wilusz J, Keene JD: Autoantibodies specific for U1 RNA and initiator methionine tRNA. J Biol Chem 261:5467-5472,1986
56. Douvas AS, Achten M, Tan EM: Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma. J Biol Chem 254:10514-10522,1979
57. Shero JH, Bordwell B, Rothfield NF, et al: Antibodies to topoisomerase I are found in sera from scleroderma patients. Science 231:737-740,1986
58. Maul GG, French BT, Van Venrooij WJ, et al: Topoisomerase I identified by scleroderma 70 antisera: Enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase. Proc Natl Acad Sci USA 83:5145-5149,1986
59. Guldner HH, Szostecki C, Vosberg HP, et al: Scl-70 autoantibodies from scleroderma patients recognize a 95 KD protein identified as DNA topoisomerase I. Chromosoma 94:132-138, 1986
60. Moroi Y, Peebles C, Fritzler MJ, et al: Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci USA 77:1627-1631,1980
61. Earnshaw WC, Rothfield NR: Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91:313-321,1985
62. Reimer G, Rose KM, Scheer U, et al: Autoantibody to RNA polymerase I in scleroderma sera. J Clin Invest 79:65-72,1987
63. Reichlin M, Maddison PJ, Targoff I, et al: Antibodies to a nuclear/nucleolar antigen in patients with polymyositis overlap syndromes. J Clin Immunol 4:40-44, 1984
64. Reimer G, Scheer U, Peters JM, et al: Immunolocalization and partial characterization of a nucleolar antigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes. J Immunol 137:3802-3808,1986
65. Targoff IN, Reichlin M: Nucleolar localization of the PM-Scl antigen. Arthritis Rheum 28:226-230, 1985
66. Reimer G, Pollard KM, Penning CA, et al: Monoclonal autoantibody from NZB/NZW FI mouse and some human scleroderma sera target a M, 34,000 nucleolar protein of the U3-ribonucle- oprotein particle. Arthritis Rheum, in press, 1987
67. Lischwe MA, Ochs RL, Reddy R, et al: Purification and partial characterization of a nucleolar scleroderma antigen (M, = 34,000; pi 8.5) rich in N°, NG-dimethylarginine. J Biol Chem260:14304-14310,1985
68. Ochs RL, Lischwe MA, Spohn WH, et al: Fibrillarin: A new protein of the nucleolus identified by autoimmune sera. Biol Cell 54:123-134,1985
69. Tan EM, Rodan GP, Garcia I, et al: Diversity of antinuclear antibodies in progressive systemic sclerosis: Anticentromere antibody and its relationship to CREST syndrome. Arthritis Rheum 23:617-625,1980
70. Muller MT, Pfund WP, Mehta VB, et al: Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active in ribosomal DNA. EMBO J 4:1237-1243,1985