Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles, pick bodies and lewy bodies

Journal of Neuropathology and Experimental Neurology

Volumn 47, Issue 4, 1988, Pages 393-405

  Love, S ^a   Saitoh, T ^a   Quijada, S ^a   Cole, G M ^a   Terry, R D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alz 50; Alzheimer s disease; Microtubule associated protein; Neurofibrillary tangle; Pick s disease; Tau protein; Ubiquitin

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; TAU PROTEIN; UBIQUITIN;

ADULT; AGED; ALZHEIMER DISEASE; CYTOCHEMISTRY; HUMAN; HUMAN CELL; LEWY BODY; NEUROFIBRILLARY TANGLE; PICK DISEASE (ARNOLD);

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; ANTIGENS; DEMENTIA; HUMAN; IMMUNOCHEMISTRY; INCLUSION BODIES; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGE; NEUROFIBRILS; NEURONS; PARKINSON DISEASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAU PROTEINS; UBIQUITINS;

EID: 0023917701     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/00005072-198807000-00001     Document Type: Article

References (32)

1. Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer’s disease do not recognize normal brain proteins. (Letter) Nature 1983;304:727–30.
2. Yen S-H, Crowe A, Dickson DW. Monoclonal antibodies to Alzheimer neurofibrillary tangles: 1. Identification of polypeptides. Am J Pathol 1985;120:282–91.
3. Anderton BH, Brienburg D, Downes MJ, et al. Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. (Letter) Nature 1982;298:84–6.
4. Sternberger NH, Sternberger LA, Ulrich J. Aberrant neurofilament phosphorylation in Alzheimer disease. Proc Natl Acad Sci USA 1985;82:4274–6.
5. Brion J-P, Passareiro E, Nunez J, Flament-Durand J. Mise en evidence immunologique de la proteine Tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d’Alzheimer. Arch Biol (Bruxelles) 1985;96:229–35.
6. Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ. Microtubule-associated protein 2: Monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci USA 1984;81:7941–5.
7. Kosik KS, Joachim CJ, Selkoe DJ. Microtubule-associated protein tau (T) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci USA 1986;83: 4044–8.
8. Grunde-Iqbal I, Iqbal K, Quinlan M, Tung Y-C, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau: A component of Alzheimer paired helical filaments. J Biol Chem 1986;261:6084–9.
9. Wood JG, Mirra SS, Pollock NJ, Binder LI. Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (T). Proc Natl Acad Sci USA 1986;83:4040–3.
10. Yen S-H, Dickson DW, Crowe A, Butler M, Shelanski ML. Alzheimer’s neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2. Am J Pathol 1987;126:81–91.
11. Probst A, Anderton BH, Ulrich J, Kohler R, Kahn J, Heitz PU. Pick’s disease: An immunocytochemical study of neuronal changes. Monoclonal antibodies show that Pick bodies share antigenic determinants with neurofibrillary tangles and neurofilaments. Acta Neuropathol (Berl) 1983;60: 175–82.
12. Dickson DW, Kress Y, Crowe A, Yen S-H. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol 1985;120:292–303.
13. Mori H, Kondo J, Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 1987;235:1641–4.
14. Perry G, Friedman R, Shaw G, Chau V. Ubiquitin is detected in neurofibrillary tangles and senile plaques neurites of Alzheimer disease brains. Proc Natl Acad Sci USA 1987;84:3033–6.
15. Cole GM, Timiras PS. Ubiquitin-protein conjugates in Alzheimer’s disease. Neurosci Letts 1987 (in press).
16. Nukina N, Ihara Y. One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem 1986;99:1541–4.
17. Wolozin BL, Pruchnicki A, Dickson DW, Davies P. A neuronal antigen in the brains of Alzheimer patients. Science 1986;232:648–50.
18. Haas AL, Bright PM. The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates. J Biol Chem 1985;260:12464–73.
19. R 60,000 protein in brain from patients with Alzheimer disease. Proc Natl Acad Sci USA 1986;83:9764–7.
20. Horoupian DS, Yang SS. Paired helical filaments in neurovisceral lipidosis (juvenile dystonic lipidosis). Ann Neurol 1978;4:404–11.
21. Rasool CG, Selkoe DJ. Sharing of specific antigens by degenerating neurons in Pick’s disease and Alzheimer’s disease. New Engl J Med 1985;312:700–5.
22. Ulrich J, Haugh M, Anderton BH, Probst A, Lautenschlager C, His B. Alzheimer dementia and Pick’s disease: Neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes. Acta Neuropathol (Berl) 1987;73:240–6.
23. Hyman BT, Van Hoesen GW, Kromer LJ. Alz-50 staining implicates cortico-cortical pathways in the pathology of Alzheimer’s disease. (Abstract) J Neuropathol Exp Neurol 1987;46:335.
24. Hershko A, Ciechanover A, Heller H, Haas AL, Rose I A. Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci USA 1980;77:1783–6.
25. Haas AL, Rose IA. Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: Role of hemin in regulating ubiquitin conjugate degradation. Proc Natl Acad Sci USA 1981;78:6845–8.
26. Goldman JE, Yen S-H, Chiu F-C, Peress NS. Lewy bodies of Parkinson’s disease contain neurofilament antigens. Science 1983;221:1082–4.
27. Fomo LS, Stemberger LA, Stemberger NH, Strefling AM, Swanson K, Eng LF. Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments. Neurosci Letts 1986;64:253–8.
28. Pappolla MA. Lewy bodies of Parkinson’s disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments. Arch Pathol Lab Med 1986;110:1160–3.
29. Pollock NJ, Mirra SS, Binder LI, Hansen LA, Wood JG. Filamentous aggregates in Pick’s disease, progressive supranuclear palsy, and Alzheimer’s disease share antigenic determinants with microtubule-associated protein, tau. (Letter) Lancet 1986;2:1211.
30. Galloway P, Grunde-Iqbal I, Autilio-Gambetti L, Gambetti P, Perry G. Neuronal cytoskeletal involvement in Lewy body formation. (Abstract) J Neuropathol Exp Neurol 1987;46:374.
31. Okamoto K, Hirano A, Yamaguchi H, Hirai S. [The fine structure of eosinophilic stages of Alzheimer’s neurofibrillary tangles.] Rinsho Shinkeigaku 1982;22:840–6.
32. Probst A, Ulrich J, Heitz PhU. Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus. An immunocytochemical and electron-microscopic study. Acta Neuropathol (Berl) 1982;57:75–9.