Glutathione mutagenesis in salmonella typhimurium is a γ-glutamyltranspeptidase-enhanced process involving active oxygen species

Carcinogenesis

Volumn 9, Issue 5, 1988, Pages 771-777

  Stark, Avishay Abraham ^a   Zeiger, Errol ^a,b   Pagano, Dennis A ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; OXYGEN;

ANIMAL EXPERIMENT; CYSTEINYLGLYCINE; MUTAGENESIS; NONHUMAN; SALMONELLA;

CATALASE; DNA DAMAGE; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HORSERADISH PEROXIDASE; MUTAGENS; OXIDATION-REDUCTION; OXYGEN; SALMONELLA TYPHIMURIUM; SUPEROXIDE DISMUTASE; SUPPORT, NON-U.S. GOV'T;

EID: 0023917659     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/9.5.771     Document Type: Article

References (48)

1. Glatt, H., Protic-Sabljid M. and Oesch, F. (1983) Mutagencity of glutathione and cysteine in the Ames test. Science, 220, 961-963.
2. Stark, A.-A., Zeiger, E. and Pagano, D.A. (1987) Glutathione mutagenesis in Salmonellayphimurium TA100: dependence on a single enzyme, y-glutamyl- transpeptidase. Mutat. Res., 177, 42-52.
3. Ross, D., Mokleus, D., Sies, H. and Smith, M.T. (1986) Mechanism and relevance of glutathione mutagenicity. Mutat. Res., 175, 127-131.
4. Mcistcr, A. and Anderson, M.E. (1983) Glutathione. Annu. Rev. Biochem., 52, 711-760.
5. Tate, S.S. and Meister, A. (1978) Serine—borate complex as a transition-state inhibitor of y-glutamyl transpepddase. Proc. Natl. Acad. Set. USA, 75, 4806 -4809
6. Tate, S.S. and Meister, A. (1974) Interaction of y-glutamyl transpeptidase with amino acids, dipeptides and derivatives and analogs of glutathione. J. Biol. Chem., 249, 7593 - 7602
7. Fiala, S., Trouet, E. (1979) Increased y-glutamyl- transferase activity in human colon cancer. Lancet, i, 1145.
8. Munjal, D.D. (1980) Concurrent measurements of carcinoembryonic antigen, glucosephosphate isomerase, y-glutamyltransferase, and lactate dehydrogenase in malignant, normal adult and fetal colon tissues. Clin. Chem, 26, 1809-1812.
9. Groscurth, P., Fleming, N. and Kistler, G.S. (1977) The activity and distribution of y-ghitamyltranspeptidase in human lung cancers serially transplanted in nude mice. Histochemistry, 53, 135-142.
10. Sahm, D.F. (1983) Gamma-glutamyltranspeptidase levels as an aid in the management of human cancer. Cancer, 52, 1673-1678.
11. Edwards, A.M. and Lucas, M. (1982) y-Glutamyltranspeptidase as a preneoplastic marker in hepalocarcinogenesis: expression in hepatocytes from normal and carcinogen-induced rats. In Smith, G.J. and Stewart, B.W. (eds), In Vitro Epithelial Cell Differentiation and Neoplasia. Australian Cancer Society, Sydney, pp. 173-191.
12. Maron, D.M. (1983) Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215.
13. Stark, A.-A., Hochman J. (1986) y-Gtutamyltranspeptidase in munne lymphomas. Eur. J. Cancer Clm. Oncol., 22, 77 - 87.
14. McCord, J.M. and Fridovich, I. (1969) Superoxide dismutase, an enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem., 244, 6049 - 6055.
15. Fridovich, I. (1982) Measuring the activity of superoxide dismutases: An embarrassment of riches. In Oberley.L.W. (ed.), Superoxide Dismutase. CRC Press, Boca Raton, FL, Vol. I, pp. 69-77.
16. Tate, S.S. and Meister, A. (1981) y4jlutamyl transpepddase: catalytic, structural and functional aspects. Mol. Cell. Biochem., 39, 357-368.
17. Mennigmann, H.D. and Pons, F. (1979) Mutation induction by thymidinedeprivation in Escherichia coli B/r. I. Influence of caffeine. Mutal. Res., 60, 13-23.
18. Pons, F. (1979) Mutation induction by thymine deprivation in Escherichia coli B/r. B. Mutation in the repressed and derepressed typtophan operon. Mutal. Res., 60, 271-278.
19. Haynes, R.H. and Kunz, B.A. (1982) DNA repair and mutagenesis in yeast. In StrathemJ.N., Jones, E.W and Broach.J.R. (eds), The Molecular Biology of the Yeast Saccharomyces. Cold Spring Harbor Laboratory Press, New York, pp 371-414.
20. Misra, H.P. (1974) Generation of superoxide free radicals during the autoxidation of thiols. J. Biol. Chem., 249, 2151-2155
21. Levin, D.E., Hollstein, M., Chrisfrnan, M.F., Schwiers, E.A. and Ames, B.N. A new Salmonella strain (TA102) with A:T base pairs at the site of mutation detects oxidauve mutagens. Proc. Natl. Acad. Sci. USA, 79, 7445 - 7449.
22. Dixon, M. and Webb, E.C. (1964) Enzymes. Longman, London, pp. 102-107.
23. AIbro, P.W.,. (1986) Generation of hydrogen peroxide by incidental metal ion-catalysed autooxidation of glutathione. J. Inorg. Biochem., 27, 191-203.
24. Freese, E (1971) Molecular mechanisms of mutation. In Hollander, A. (ed.), Chemical Mutagens. Principles and Methods for Their Detection. Plenum Press, New York, pp 1-56.
25. Lesko, S.A. (1980) Role of superoxide in deoxyribonucleic acid strand scission. Biochemistry, 19, 3023-3028.
26. Rigo, A., Scarpa, M., Argese, E., Ugo, P. and Viglino, P. (1984) Generation of superoxide in the auto-oxidation of ascorbate and glutathione. In Bors.W., Satan, M. and Tait.D. (eds), Oxygen Radicals in Chemistry and Biology. Walter de Gruyer, Berlin and New York, pp. 171-176.
27. Harman, L.S., Carver, D.K., Schreiber I. and Mason, R.P. (1986) One- and two-electron oxidation of reduced glutathione by peroxidases. J. Biol. Chem., 261, 1642-1648
28. Mottley.C. and Mason, R.P. (1984) Free radical metabolites of L-cysteine oxidation. J. Biol. Chem., 259, 5606-5611.
29. Saez, G. (1982) The production of free radicals during the auto-oxidation of cysteine and their effects on isolated rat hepatocytes. Biochim. Biophys. Acta, 719, 24-31.
30. Eling, T.E., Curtis J.F., Harman, L.S. and Mason, R.P. (1986) Oxidation of glutathione to its thiyl free-radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. J. Biol. Chem., 261, 5023 - 5028.
31. Halliwell, B. (1985) Free Radicals in Biology and Medicine. Clarendon Press, Oxford, p. 64.
32. Friedman, M., CavinsJ, F. and Wall J.S. (1965) Relative nucleophilic reactivities of amino groups and mercaptide ions in addition reactions with a,/3-unsaturaled compounds. J. Am. Chem. Soc., 87, 3672-3682.
33. Halliwell, B (1982) The toxic effects of oxygen on plant tissues. In Oberley, L. (ed.), Superoxide Dismutase. CRC Press, Boca Raton, FL, Vol I, pp 89-123.
34. Fiala, S., Mohindru, A., Kettering, W.G., Fiala, A.E and Morris, H.P. (1976) Glutathione and y-glutamyltranspcptidase in rat liver during chemical carcinogenesis. J. Natl. Cancer Inst., ST, 591-598.
35. Pilot, H.C. (1980) Characteristics of stages of hepatocarcinogenesis. In Pullman, B., Ts’o.P.O.P. and Gelboin.H. (eds), Carcinogenesis: Fundamental Mechanisms and Environmental Effects. D.Reidel Publishing Co., Hingham, MA, pp. 219-233.
36. Hanigan, H.M. and Pitot, H.C. (1982) Isolation of 7-glutamyl transpeptidase positive hepatocytes during early stages of hepatocarcinogenesis in the rat. Carcinogenesis, 3, 1349-1354.
37. Kalanagyi, M.M.R., Ronchi, G. and Desmet, VJ. (1975) Histochemistry of 7-glutamyl transpeptidase in rat liver during aflatoxin B,-induced carcinogenesis. J. Natl. Cancer Inst., 55, 579 - 588.
38. Moore, M.R., Pitot, H.C., Miller, E.C. and Miller, J.A. (1982) Cholangio- cellular carcinomas induced in Syrian golden hamsters administered aflatoxin B in large doses. J. Natl. Cancer Inst., 68, 27-278.
39. Pugh, T.D. and Goldfarb, S. (1978) Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital. Cancer Res., 38, 4450 - 4457.
40. Farber, E. (1980) The sequential analysis of liver cancer induction. Biochim. Biophys. Acta, 605, 149-166.
41. Manson, M.M., Legg, R.F., Watson J.V., Green J. and Neal, G.E. (1981) An examination of the relative resistances to aflatoxin B and susceptibilities of 7-glutamyl-p-phenylenediamine mustard of 7-glutamyl transferase negative and positive cell lines. Carcinogenesis, 2, 661-670.
42. Neal, G.E., Metcalfe, S.A., Legg, R.F., Judah, D.J. and Green J.A. (1981) Mechanism of the resistance to cytotoxicity which precedes aflatoxin B! hepatocarcinogenesis. Carcinogenesis, 2, 457-461.
43. Oagawa, K.,. (1980) Phenotypic diversity as an early
44. Solt, D.B., Medline, A. and Farber, E. (1977) Rapid emergence of carcinogen- induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am. J. Pathol., 88, 595-618.
45. Tsuda, H., Lee, G. and Farber, E. (1980) Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res., 40, 1157-1164.
46. Cerut U.P. (1985) Prooxidant stales and tumor promotion. Science, 227, 375-381.
47. Perchelle U.P., Perchcllet, E.M., Orten, D.K. and Schneider, B.A. (1986) Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters. Carcinogenesis, 7, 503-506.
48. Ahluwalia, M.B., Rotstein J., Tatemasu, M., Roomi, M. and Farber, E. Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model. Carcinogenesis, 4, 119-121.