Muscarinic receptor differentiation

Pharmacology and Therapeutics

Volumn 37, Issue 3, 1988, Pages 357-423

  Mitchelson, F ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; MUSCARINIC RECEPTOR; PIRENZEPINE;

CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; GASTROINTESTINAL TRACT; HUMAN; NONHUMAN; REVIEW; SECOND MESSENGER;

CARDIOVASCULAR SYSTEM; CELL LINE; GALLAMINE TRIETHIODIDE; GASTROINTESTINAL SYSTEM; MUSCLE, SMOOTH, VASCULAR; PARASYMPATHOMIMETICS; PHOSPHATIDYLINOSITOLS; PIRENZEPINE; RECEPTORS, MUSCARINIC; SUPPORT, NON-U.S. GOV'T;

EID: 0023916293     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(88)90005-8     Document Type: Article

References (461)

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89. Batrachotoxin changes the properties of the muscarinic receptor in rat brain and heart: Possible interaction(s) between muscarinic receptors and sodium channels
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100. Action of different agonists and antagonists of the cholinergic system on the rat lower esophageal sphincter
101. Muscarinic cholinoceptors in the rabbit myometrium: A study of the relationship between binding and response
102. Muscarinic cholinergic receptors in a rat phaeochromocytoma cell line
103. Structural microheterogeneity of the muscarinic cholinergic receptor is not related to functional diversity identified by differences in affinity for pirenzepine
104. The action of certain esters and ethers of choline, and their relation to muscarine
105. A comparison of the muscarinic antagonist actions of pancuronium and alcuronium
106. Receptors for neurotransmitters in opossum oesophagus muscularis mucosa
107. Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3′,5′-cyclic monophosphate
108. Role of calcium mobilization in mediation of acetylcholine-evoked chloride currents in Xenopus laevis oocytes
109. Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes
110. The effects of atropine and secoverine on gastric secretion and motility in the mouse isolated stomach
111. Biochemical evidence for the presence of presynaptic receptors on dopaminergic nerve terminals
112. Muscarinic receptors discriminated by pirenzepine are involved in the regulation of neurotransmitter release in rat nucleus accumbens
113. Heterogeneity of muscarinic receptor binding sites in rat brain, submandibular gland and atrium
114. A comparison between muscarinic receptor occupancy, adenylate cyclase inhibition, and inotropic response in human heart
115. Heterogeneous behaviour of the canine arterial and venous wall
116. Effect of LY83583 on carbachol-induced cyclic GMP elevation and inhibition of contractile force in rabbit atrial strips
117. A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat
118. Nucleotide binding proteins in signal transduction and disease
119. Discrimination by N-ethylmaleimide between the chronotropic and inotropic response to muscarinic receptor stimulation in rat atrium
120. AF-DX 116 BS: A cardioselective muscarinic antagonist
121. Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle
122. Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium
123. Effects of pirenzepine and MDL72222 on contractions of the cat nictitating membranes to muscarinic agonists
124. 3H]QNB binding to putative cholinergic receptors
125. 2-muscarinic receptors to excite rat locus coeruleus neurones
126. 2 muscarinic receptor
127. Determination of the muscarinic receptor subtype mediating vasodilatation
128. Differential affinities of muscarinic antagonists at ileal and atrial receptors
129. Muscarinic receptor subtypes A critique of the current classification and a proposal for a working nomenclature
130. Muscarinic receptor subtypes in the ileum, atria and taenia caecum of the guine-pig
131. The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in rabbit myocardium
132. 3H]cismethyldioxolane
133. Muscarinic receptor regulation by guanine nucleotides, ions and N-ethylmaleimide
134. Muscarinic receptor-mediated phosphoinositide metabolism in guinea-pig parotid gland, ileum and cortex
135. 2 receptor subtypes
136. Competitive interaction of pirenzepine with rat brain muscarinic acetylcholine receptors
137. Analysis of regional variations in the affinities of muscarinic agonists in the rat brain
138. Competitive interactions of gallamine with multiple muscarinic receptors
139. Characterization of the interactions of gallamine with muscarinic receptors from brain
140. Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug
141. Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart
142. 3H]serotonin from rat hypothalamic slices
143. Muscarinic cholinergic receptor sites in cerebral blood vessels
144. Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms
145. Cardiac muscarinic cholinergic receptors
146. Inositol lipids and signal transduction at CNS muscarinic receptors
147. Muscarinic agonist binding and phospholipid turnover in brain
148. 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace-maker tissue?
149. Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins
150. Different effects of N-ethylmaleimide on M1 and M2 muscarine receptors in rat brain
151. Effect of solubilization on the distinct binding properties of muscarine receptors from rabbit hippocampus and brain stem
152. The role of endothelial and non-endothelial prostaglandins in the relaxation of isolated blood vessels of the rabbit induced by acetylcholine and bradykinin
153. Release-modulating acetylcholine receptors on cholinergic neurones of the guinea-pig ileum
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157. Pharmacological and biochemical evolution of muscarinic receptors of brain and heart tissues of vertebrates
158. Pharmacologic studies of N-benzyl-3-pyrrolidyl acetate methobromide (AHR-602), a ganglion stimulating agent
159. Regional differences in muscarinic receptor linked inositol phospholipid hydrolysis
160. Apparent affinities of muscarinic antagonists and agonists at binding sites in rat heart and brain
161. Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig
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163. The affinity of pirenzepine and other antimuscarinic compounds for pre- and postsynaptic muscarinic receptors of the isolated rabbit and rat heart
164. The effects of several muscarinic antagonists on pre- and postsynaptic receptors in the isolated rabbit heart
165. Sympathetic nerve stimulation on the perfused rat heart
166. Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart
167. The muscarinic receptor of vascular endothelium that subserves vasodilation
168. Cholinergic transmission in cat parasympathetic ganglia
169. The effect of pancuronium and gallamine on muscarinic transmission in the superior cervical ganglion
170. Distinct muscarinic mediation of suspected dopaminergic activity in sympathetic ganglions
171. Comparison of the effect of muscarinic agonists on phosphoinositide turnover and contractile response in the guinea-pig taenia caeci
172. Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle
173. Muscarinic receptor subtypes and responses to McN-A-343 and pirenzepine
174. Functional and biochemical evidence for muscarinic receptor subtypes in the gastrointestinal tract
175. 1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine
176. 2 receptor antagonist
177. 2 antagonist, discriminates among peripheral muscarine receptors
178. Differences in affinities of muscarinic acetylcholine receptor antagonists for brain and heart receptors
179. 2-acetylcholine receptors
180. Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase
181. Muscarinic cholinergic receptor binding sites differentiated by their affinity for pirenzepine do not interconvert
182. The cardio-selectivity of himbacine A muscarine receptor antagonist
183. Pharmacologic identification, activation and antagonism of two muscarine receptor subtypes in the lower esophageal sphincter
184. Changes in membrane currents in bullfrog atrium produced by acetylcholine
185. G Proteins and dual control of adenylate cyclase
186. Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat
187. Comparisons of dissociation constants and relative efficacies of muscarinic agonists in the hippocampal slice preparation and the guinea-pig ileum
188. Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter
189. Comparative studies of the postjunctional activities of some very potent muscarinic agonists
190. Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: Relationship to contraction and muscarinic receptor occupancy
191. Atropine exhibits a selectivity of action in the small intestine
192. The action of secoverine hydrochloride and atropine sulphate on rat intestinal motility and secretion in vivo
193. Comparison of endothelium-dependent relaxation in bovine intrapulmonary artery and vein by acetylcholine and A 23187
194. Rat brain and heart muscarinic receptors: Modification with tetranitromethane
195. Dual pathways in muscarinic receptor stimulation of phosphoinositide hydrolysis
196. 3H]acetylcholine and its modulation by transition metal ions and guanine nucleotides
197. 3H]acetylcholine to muscarinic receptors
198. Pirenzepine does not discriminate between pre- and postsynaptic muscarinic receptors in the guinea-pig small intestine
199. Three of a kind: The β-adrenergic receptor, the muscarinic acetylcholine receptor, and rhodopsin
200. Subclasses of muscarinic receptors and pirenzepine. Further experimental evidence
201. 2 biochemical and functional characterization
202. Selective muscarinic receptor antagonists
203. Pirenzepine distinguishes between different subclasses of muscarinic receptors
204. 1-receptor antagonist
205. Binding profile of a novel cardioselective muscarine receptor antagonist, AF DX 116, to membranes of peripheral tissues and brain in the rat
206. Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s)
207. Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors
208. Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: Demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment
209. Characteristics of two biochemical responses to stimulation of muscarinic cholinergic receptors
210. Assessment of the muscarinic subtype selectivity of (±)3-quinuclidinyl xanthene-9-carboxylate hemioxalate hydrate (QNX)
211. Muscarinic antagonists induce different receptor conformations in rat adenohypophysis
212. Role of cholinergic receptors in the release of newly synthesized amines from serotonergic and dopaminergic nerve terminals
213. 0, regulates neuronal calcium channels
214. Effect of proteolytic cleavage on functional properties of muscarinic acetylcholine receptors in rat pancreatic and parotid acinar cells
215. Muscarinic acetylcholine receptor structure in acinar cells of mammalian exocrine glands
216. + conductance underlies the slow inhibitory postsynaptic potential in sympathetic ganglia
217. Effect of N-ethylmaleimide on muscarinic acetylcholine receptor subtype autoradiography and inositide response in rat brain
218. Regulation of ligand binding to cardiac muscarinic receptors by ammonium ion and guanine nucleotides
219. Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321 N1 astrocytoma cells
220. Distinctions in acetylcholine receptor activity
221. Regulation of muscarinic agonist binding by cations and guanine nucleotides
222. Two populations of binding sites for muscarinic antagonists in the rat heart
223. Characterization of muscarinic receptors of the rabbit ear artery smooth muscle and endothelium
224. Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery
225. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: Stimulation by acetylcholine, bradykinin and arachidonic acid
226. Membrane currents and their modification by acetylcholine in isolated single atrial cells of the guinea-pig
227. 2+-dependent action potentials in chick heart
228. Influence of acetylcholine on the positive inotropic effect evoked by α- or β-adrenoceptor stimulation in rabbit heart
229. Muscarinic receptors and hydrolysis of inositol phospholipids in rat cerebral cortex and parotid gland
230. Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum
231. 2 cholinergic receptors does not antagonize cholinergic inhibition of adenylate cyclase in isolated plasma membrane
232. Non-muscarinic stimulation and block of a sympathetic ganglion by 4-(m-chlorophenyl carbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343)
233. Muscarinic stimulation of prostacyclin synthesis by the rat penis
234. 3H-labelled antagonist competition
235. Heterogeneity of muscarinic receptors in the guinea-pig oesophageal muscularis mucosa and ilead longitudinal muscle
236. Lithium ions inhibit function of low- but not high-affinity muscarinic receptors of murine neuroblastoma cells (Clone N1E 115)
237. 1) receptor mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (Clone N1E 115)
238. The effect of atropine upon acetylcholine release from cat superior cervical ganglion and rat cortical slices: Measurement by a radio-enzymic method
239. Acetylcholine
240. The classification of drugs and drug receptors in isolated tissues
241. The effect of dicyclomine and trifluoperazine on muscarinic receptors
242. Cardiotropic antimuscarinic action of some curare-like agents
243. Antimuscarinic and ganglion-blocking activity of neuromuscular blocking agents
244. Presynaptic muscarine receptors modulating acetylcholine release
245. Facilitation and inhibition by muscarinic agonists of acetylcholine release from guinea-pig myenteric neurones: Mediation through different types of neuronal muscarinic receptors
246. Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus
247. Inhibition by oxotremorine of acetylcholine resting release from guinea-pig ileum longitudinal muscle strips
248. Pre- and postsynaptic effects of muscarinic agonists in the guinea-pig ileum
249. Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum
250. Bisquaternary pyridinium oximes as allosteric inhibitors of rat brain muscarinic receptors
251. Allosteric interactions between muscarinic agonist binding sites and effector sites demonstrated by the use of bisquaternary pyridinium oximes
252. Characterization of muscarinic acetylcholine receptors from mouse brain: Evidence for regional heterogeneity and isomerization
253. Bisquaternary pyridinium oximes as presynaptic agonists and postsynaptic antagonists of muscarinic receptors
254. Comparison of the muscarinic cholinoceptors in the rabbit ciliary body and the guinea-pig ileum
255. N-Ethylmaleimide-induced alteration in the interaction of agonists with muscarinic cholinergic receptors of rat brain
256. Cloning, sequencing and expression of complementary DNA encoling the muscarinic acetylcholine receptor
257. Functions of cyclic GMP in acetylcholine-induced contraction of coronary smooth muscle
258. Possible allosteric interaction of 4-aminopyridine with rat brain muscarinic acetylcholine receptors
259. Structure and conformation activity relationships of heterocyclic acetylcholine analogues X. The inhibitory effect of 3-quinuclidinyl benzilates on cardiac muscarinic receptors
260. Selective inhibition of muscarinic receptors in intestinal smooth muscle
261. Heterogeneity in muscarinic receptors. Evidence from pharmacological studies with agonists and antagonists
262. Hexahydrosiladifenidol A selective antagonist on ileal muscarinic receptors
263. Heterogeneity in muscarinic receptors: Evidence from pharmacological and electrophysiological studies with selective antagonists
264. 2 receptor subtypes in a series of antimuscarinic agents of the procyclidine and difenidol type and their sila-analogues
265. Pirenzepine has similar affinities for pre- and postjunctional muscarinic receptors
266. Pirenzepine indicates heterogeneity of muscarinic receptors linked to cerebral inositol phospholipid metabolism
267. Heterogeneity of binding of muscarinic receptor antagonists in rat brain homogenates
268. Muscarinic receptor-mediated phosphoinositide turnover breakdown in guinea-pig myometrium. A possible mechanism that triggers contraction and cGMP accumulation
269. The interaction of pancuronium with cardiac and ileal muscarinic receptors
270. Modification by hexamethonium of the muscarinic receptor blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig
271. Muscarinic receptor inhibition and other effects of pancuronium in the rabbit ear artery preparation
272. Stimulation of phosphatidylinositol metabolism in atrial and ventricular myocytes
273. The effect of stercuronium on cardiac muscarinic receptors
274. The selective antimuscarinic action of stercuronium
275. Dopamine as a synaptic transmitter and modulator in sympathetic ganglia: A different mode of synaptic action
276. 2+ transport in guinea-pig ventricles
277. Differential cholinergic sensitivity of sinus and AV nodes
278. A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation
279. The parasympathetic neuroeffector junction of the heart
280. Der Einfluss von Atropin auf die Noradrenalin-Freisetzung durch Acetylcholin
281. + channel in heart
282. Acetylcholine-induced inhibition of responses to field stimulation in rabbit pulmonary artery is unaffected by endothelial removal
283. Inhibition of the actions of carbachol and DFP on guinea-pig isolated atria by alkane-ammonium compounds
284. 3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain
285. 3H]quinuclidinylbenzilate binding to brain muscarinic cholinergic receptors
286. 3H]pirenzepine binding to muscarinic cholinergic receptors solubilized from rat brain
287. The interaction of carbachol and forskolin in rabbit papillary muscles
288. Effects of the cyclic GMP lowering agent LY83583 on the interaction of carbachol with forskolin in rabbit isolated cardiac preparations
289. The interaction of hemicholinium-3 (HC-3) with cholinomimetics and atropine
290. Facilitation of noradrenaline release by gallamine in the rat salivary gland
291. Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea-pig myometrium
292. On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties
293. Autoregulation of acetylcholine release in isolated hippocampal nerve endings
294. Is the muscarinic receptor that mediates potentiation of dopamine release negatively coupled to the cyclic GMP system?
295. Actions of non-depolarizing neuromuscular blocking agents at cholinoceptors other than at the motor end plate
296. Comparison of the autonomic effects of some currently-used neuromuscular blocking agents
297. Comparison of the cardiovascular actions of ORG NC 45 with those produced by other non-depolarizing neuromuscular blocking agents in experimental animals
298. Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart
299. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta
300. 2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation
301. Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells
302. Pertussis toxin does not inhibit muscarinic receptor mediated phosphatidylinositide hydrolysis of calcium mobilization
303. Two types of muscarinic response to acetylcholine in mammalian cortical neurons
304. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
305. Pirenzepine discriminates among ionic responses to acetylcholine in guinea-pig cerebral cortex and reticular nucleus of thalamus
306. The dual mode of the antispasmodic effect of dicyclomine hydrochloride
307. Blockade of N1E-115 murine neuroblastoma muscarinic receptor function by agents that affect the metabolism of arachidonic acid
308. Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115): Cyclic GMP formation is mediated by a low affinity agonist-receptor conformation and cyclic AMP reduction is mediated by a high affinity agonist-receptor conformation
309. Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115)
310. Agonist interactions with cardiac muscarinic receptors
311. Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment
312. Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors
313. Mechanism of acetylcholine release: Possible involvement of presynaptic muscarinic receptors in regulation of acetylcholine release and protein phosphorylation
314. Dissociation between the electrophysiological properties and total tissue cyclic guanosine monophosphate content of guinea-pig atria
315. Pharmacological studies on the isolated taenia of the guinea-pig caecum
316. Antimuscarinic action of an alkane-bis-ammonium compound alone and in combination with (+)benzetimide
317. Multiple agonist binding sites of muscarinic acetylcholine receptors and their relation to the negative inotropic action of agonists in guinea-pig heart
318. Muscarinic agonists inactivate potassium conductance of guinea-pig myenteric neurones
319. Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea-pig ileum
320. Slow cholinergic excitation of guinea-pig hippocampal neurons in mediated by two muscarinic receptor subtypes
321. 2 muscarinic receptor subtypes
322. Regulation of catecholamine release. The muscarinic inhibitory mechanism
323. Xanthine derivatives that selectively inhibit cyclic GMP hydrolysis potentiate cardiac contractile effects of isoproterenol but not those of bethanecol
324. Selective muscarinic agonists and antagonists in functional tests
325. Modulation by the muscarinic agonist McN-A-343 of noradrenaline release from vascular sympathetic neurones
326. Dual effect of the muscarinic agonist McN-A-343 on vascular neuroeffector transmission
327. Interaction of neuromuscular blocking drugs alcuronium, decamethonium, gallamine, pancuronium, ritebronium, tercuronium, and d-tubocurarine with muscarinic acetylcholine receptors in the heart and ileum
328. Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs
329. Receptor-operated Ca channels
330. Pharmacological distinction between two muscarinic responses on the isolated superior cervical ganglion of the rat
331. On the muscarinic receptors in the urinary bladder and the putative subclassification of muscarinic receptors
332. Differences between binding affinities of some antimuscarinic drugs in the parotid gland and those in the urinary bladder and ileum
333. Dicyclomine, benzhexol and oxybutynine distinguish between subclasses of muscarinic binding sites
334. GTP-binding proteins couple cardiac muscarinic receptors to potassium channels
335. Muscarinic autoreceptor regulates acetylcholine release in rat hippocampus: In vitro evidence
336. Presynaptic antagonist-postsynaptic agonist at muscarinic cholinergic synapses
337. Effects of in vivo and in vitro treatments with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on putative muscarinic receptor subtypes in rat brain
338. Muscarinic receptors and membrane ion conductances
339. Receptors on individual neurones
340. 2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system
341. Mechanism of action of muscarine on the longitudinal muscle of the guinea-pig isolated ileum
342. Adenylate cyclase activity of synaptic membranes from rat striatum
343. Muscarinic receptor subtype in the rat anococcygeus muscle
344. Inositol 1,4,5-triphosphate mimics muscarinic response in Xenopus oocytes
345. The pharmacological assessment of RS 86 (2-ethyl-8-methyl-28-diazaspiro-[45]-decan-13-dion hydrobromide) A potent specific muscarinic acetylcholine receptor agonist
346. Mapping of subtypes of muscarinic receptors in the human brain with receptor autoradiographic techniques
347. Development of different electrophysiological mechanisms for muscarinic inhibition of atria and ventricles
348. Changes in intracellular calcium and in membrane currents evoked by injection of inositol trisphosphate into Xenopus ooxytes
349. 2 receptor subtype
350. Mechanisms of endothelium-dependent vascular smooth muscle relaxation
351. Purification of the muscarinic acetylcholine receptor from porcine atria
352. GTP-binding proteins couple cardiac muscarinic receptors to a K channel
353. Muscarinic M2-receptors enhance polyphosphoinositol release in rat gastric mucosal cells
354. 1-adrenergic, muscarinic or electrical stimulation in isolated rat heart
355. 2 receptors: Ligands, autoradiography and functions
356. Activation of muscarinic receptors in PC 12 cells
357. Regional distribution of muscarinic receptors preferring gallamine in the rat brain
358. 3H]acetylcholine receptors in rat brain: Comparison with antagonists
359. Heterogeneity of presynaptic receptors regulating neurotransmitter release in the rat brain
360. Presynaptic muscarinic receptors increase striatal dopamine release evoked by ‘quasi-physiological’ depolarization
361. Cardiovascular effects of choline esters
362. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP
363. 2 muscarinic receptor subtypes in the control of the lower esophageal sphincter in the opossum
364. N-Alkyl-N-(4-tert-amino-1-methyl-2-butynyl) carboxamides, a new class of potent oxotremorine antagonists
365. The pharmacology of flaxedil with observations on certain analogs
366. 3H]quinuclidinyl benzilate to intestinal mucus
367. Effects of inhibitors of arachidonic acid metabolism and calcium entry on responses to acetylcholine, potassium and norepinephrine in the isolated canine saphenous vein
368. Determination of dissociation constants and relative efficacies of oxotremorine analogs at muscarinic receptors in the guinea-pig ileum by pharmacological procedures
369. Affinity, efficacy and stereoselectivity of oxotremorine analogues for muscarinic receptors in the isolated guinea-pig ileum
370. Functional experiments with antimuscarinic agents in various smooth muscle organs
371. Differences in the chronotropic and inotropic response of the rat atrium to choline esters, cholinesterase inhibitors and certain blocking agents
372. Muscarinic receptors in rat nasal mucosa are predominantly of the low affinity agonist type
373. The study of the occupancy-biological effect relationship by irreversible inactivation of muscarinic receptors in guinea-pig ileum
374. 3H](−)quinuclidinylbenzilate binding to soluble rat brain muscarinic receptors indicates that pirenzepine binds to an allosteric state of the muscarinic receptor
375. Muscarinic cholinergic receptor regulation
376. The regulation of cardiac muscarinic cholinergic receptors by isoproterenol
377. An unusual type of sympathetic ganglion stimulant
378. + channels in isolated pacemaker cells of the mammalian heart
379. Inhibition of neuronal uptake of noradrenaline in the isolated perfused rat heart by pancuronium and its homologues, ORG.6368, ORG.7268 and NC45
380. Secoverine hydrochloride is a muscarinic antagonist in human isolated gastrointestinal muscle and myometrium
381. Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the guinea-pig ileum and its status after chronic exposure to morphine
382. Mechanism of selective cardiac vagolytic action of pancuronium bromide. Specific blockade of cardiac muscarinic receptors
383. Synergistic effects of alpha-1 and muscarinic receptors on phosphatidylinositol breakdown in murine atria
384. + channel in PC 12 pheochromocytoma cells which hyperproduce the apamin receptor
385. 14C]acetylcholine release from rat neostriatal slices: Selective antagonism by gallamine but not pirenzepine
386. Muscarinic receptor heterogeneity revealed by interaction with bretylium tosylate
387. Disopyramide and quinidine bind with inverse selectivity to muscarinic receptors in cardiac and extracardiac rat tissues
388. Rate constants of agonist binding to muscarinic receptors in rat brain medulla
389. The effects of racemic bethanecol and its (R)- and (S)-enantiomers on pre- and postjunctional muscarine receptors in guinea-pig ileum
390. Comparison of muscarinic and α-adrenergic receptors in rat atria based on phosphoinositide turnover
391. Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle
392. Cholinergic muscarinic binding by rat lymphocytes: Effects of antagonist treatment, strain and aging
393. 3H-acetylcholine to cholinergic receptors in bovine cerebral arteries
394. Molecular characterization of muscarinic receptor subtypes in bovine cerebral cortex by radiation inactivation and molecular exclusion h.p.l.c.
395. Cholinergic agonists suppress a potassium current in freshly dissociated smooth muscle cells of the toad
396. A mechanism of muscarinic excitation in dissociated smooth muscle cells
397. Muscarinic receptors in the central nervous system
398. Biochemical characterization of the muscarinic receptors
399. Modulation of muscarinic receptors and their interactions
400. Fundic mucosal muscarinic receptors modulating acid secretion
401. Comparison of muscarinic receptor properties in hatched chick heart atrium and ventricle
402. Autoradiographic analysis of receptors on vascular endothelium
403. Modification of the binding properties of muscarinic receptors by gallamine
404. Influence of “selective” antimuscarinic agents on gastric acid secretion and motility
405. Induction of muscarinic cholinergic responsiveness in Xenopus oocytes by mRNA isolated from rat brain
406. Muscarinic receptors in the submucous plexus and their roles in mucosal ion transport
407. Does pirenzepine distinguish between ‘subtypes’ of muscarinic receptors?
408. 3H]acetylcholine from rat hippocampal slices: Effect of septal lesion and of graded concentrations of muscarinic agonists and antagonists
409. Interaction of muscarinic drugs with their receptors
410. Interactions of muscarinic drugs with their receptors in single cells of guinea-pig taenia caecum
411. Receptor regulation of calcium entry
412. Receptor coupling to polyphosphoinositide turnover: A parallel with the adenylate cyclase system
413. The effects of dihydrochandonium and other chandonium analogues on neuromuscular and autonomic transmission
414. On the mechanism of the negative inotropic effect of acetylcholine
415. Intestinal epithelial cells and musculature contain different muscarinic binding sites
416. The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells
417. Effects of guanine nucleotide and sulphydryl reagents on subpopulations of muscarinic acetylcholine receptors in mammalian heart: Possible evidence for interconversion of super-high and low affinity agonist binding sites
418. Subclassification of muscarinic receptors in the heart urinary bladder and sympathetic ganglia in the pithed rat
419. Comparison of in vivo potencies of muscarinic antagonists on vascular endothelium, sympathetic ganglia, heart and salivary glands
420. General theory of drug-receptor interactions. Drug-receptor interaction models. Calculation of drug parameters
421. Molecular distinction between calf heart and brain muscarine receptors: Different N-ethylmaleimide modulation of agonist binding
422. Muscarinic cholinergic receptor structure
423. 1-adrenergic receptors
424. Gallamine and pancuronium inhibit pre- and postjunctional muscarinic receptors in canine saphenous veins
425. Activation of muscarinic receptors in PC 12 cells
426. 3H]cismethyldioxolane
427. Differential regulation of putative M1/M2 muscarinic receptors: Implications for different receptor-effector couping mechanisms
428. 3H]quinuclidinylbenzilate binding sites
429. Muscarinic and nicotinic stimulant actions at autonomic ganglia
430. Characterization of muscarinic receptors
431. Muscarinic receptors on rat ileal villus and crypt cells
432. Rat cardiac muscarinic receptors
433. 3H]-N-methylscopolamine binding to muscarinic receptors in the rat central nervous system: Evidence for the existence of three classes of binding sites
434. 1 muscarinic receptors, exerts antinicotinic and antimuscarinic effects in the rat adrenal medulla
435. 3H]pirenzepine
436. Interaction between cyclic adenosine monophosphate and cyclic guanosine monophosphate in guinea-pig ventricular myocardium
437. Mechanism of muscarinic modulation of protein phosphorylation in intact ventricles
438. 3H]pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex
439. 2 muscarinic receptor subtypes
440. Subclassification of muscarinic receptors based upon the selective antagonist pirenzepine
441. 3H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. ii. Characterization and regulation of antagonist binding to putative muscarinic subtypes
442. 3H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. i. Characterization and regulation of agonist binding to putative muscarinic subtypes
443. Heart atrial cholinergic receptor sites show greater affinity towards agonist compared to ventricular sites
444. Requirement for sulphydryl groups in the differential effects of magnesium ion and GTP on agonist binding of muscarinic cholinergic receptor sites in rat atrial membrane fraction
445. A comparison of the antimuscarinic effects of pirenzepine and N-methylatropine on ganglionic and vascular muscarinic receptors in the rat
446. 1 receptors by a series of tertiary arecaidine and isoarecaidine esters in the pithed rat
447. Presynaptic modulation of acetylcholine release from cardiac parasympathetic neurons
448. Tissue slices in radioligand binding assays: Studies in brain, pineal and muscle
449. Antagonist-like action of oxotremorine on a muscarinic receptor in guinea-pig olfactory cortex in vitro
450. Muscarinic depression of evoked surface-negative field potentials recorded from guinea-pig olfactory cortex in vitro
451. A comparison of muscarinic acetylcholine receptors coupled to phosphatidylinositol turnover and to adenylate cyclase in guinea-pig atria and ventricles
452. Postsynaptic localization of muscarinic cholinergic receptor binding in rat hippocampus
453. 3H]quinuclidinyl benzilate
454. 3H]pirenzepine
455. 3H](−)quinuclidinyl benzilate binding in human stellate ganglia
456. Species difference in the muscarinic receptors of thoracic aorta
457. K
458. Muscarinic acetylcholine receptor and smooth muscle contraction
459. Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1. Antimuscarinic and spasmolytic effects
460. Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2. General pharmacological properties
461. Secoverine selectively antagonizes muscarinic effects in various in vivo preparations