Propofol: A Review of its Pharmacodynamic and Pharmacokinetic Properties and Use as an Intravenous Anaesthetic

Drugs

Volumn 35, Issue 4, 1988, Pages 334-372

  Langley, Mark S ^a,b   Heel, Rennie C ^a  

^a Manchester International Law Centre   (United Kingdom)

^b ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; ENFLURANE; ETOMIDATE; FENTANYL; HALOTHANE; ISOFLURANE; METHOHEXITAL; NITROUS OXIDE; OPIATE; PROPOFOL; THIOPENTAL;

ANESTHESIA; APNEA; DRUG THERAPY; EXCITATION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NAUSEA; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; VOMITING;

ANESTHESIA, INTRAVENOUS; ANESTHETICS; ANIMAL; HUMAN; PHENOLS; PROPOFOL;

EID: 0023916186     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/00003495-198835040-00002     Document Type: Article

References (117)

1. ICI 35868 Pharmacokinetics in humans: single dose studies
2. Pharmacokinetic evaluation of ICI 35868 in man
3. Blood disoprofol levels in anaesthetised patients
4. Effect of premedication with atropine or hydroxyzine on induction and maintenance of anaesthesia with propofol
5. Comparison of the effect of disopropyl phenol (ICI 35868) and thiopentone on response to somatic pain
6. The effects of premedication on anaesthesia with propofol (‘Diprivan’)
7. Adverse reactions to intravenous anaesthetics. A survey of 100 reports
8. Hemodynamic effects of infusions of the emulsion formulation of propofol during nitrous oxide anaesthesia in humans
9. Haemodynamic responses to induction and endotracheal intubation with propofol/nitrous oxide anaesthesia
10. Propofol (‘Diprivan’) pharmacokinetics and metabolism — an overview
11. Pharmacokinetics of propofol in female patients
12. Dose requirements of ICI 35868 (Propofol, ‘Dipnvan’) in a new formulation for induction of anaesthesia
13. Use of an emulsion formulation of propofol (‘Dipnvan’) in intravenous anaesthesia for termination of pregnancy a comparison with methohexitone
14. Companson of propofol with methohexitol for outpatient anesthesia
15. Alterations in response to somatic pain associated with anaesthesia I: the effect of thiopentone and pentobarbitone
16. Sensitivity to propofol in the elderly
17. Suspected anaphylactic reactions to Cremophor EL
18. A comparison of the induction characteristics of thiopentone and propofol (2,6-di-isopropyl phenol)
19. The effect of propofol on adrenocortical steroidogenesis a comparative study with etomidate and thiopental
20. Drug kinetics and hepatic blood flow
21. Disposition of propofol administered as zero-order intravenous infusions in humans
22. Pharmacokinetics of propofol (‘Dipnvan’) administered by continuous intravenous infusion in man a preliminary report
23. Infusion of propofol (‘Dipnvan’) as a sedative technique for colonoscopies
24. Pharmacology of an emulsion formulation of ICI 35868
25. Some ventilatory effects of propofol as a sole anaesthetic agent
26. Anaesthesia for laparoscopy
27. Companson of etomidate and propofol for anaesthesia in microlaryngeal surgery
28. Propofol (‘Dipnvan’) emulsion for total intravenous anaesthesia
29. Propofol infusion for sedation in the intensive care unit preliminary report
30. Acute ventilatory changes during i v induction of anaesthesia with thiopentone or propofol in man
31. The haemodynamic effects of intravenous induction
32. Changes in intra-ocular pressure in the elderly during anaesthesia with propofol
33. Propofol and emesis
34. Intrakranielles druckverhalten bei patienten mit schadel-hiru-trauma nach propofol-bzw
35. 2 anaesthesia for long-lasting abdominal operations
36. Retentissement electroencephalographique de l’anesthesic au propofol
37. Propofol vs thiopentone as anaesthetic agents for short operative procedures
38. EEG and EMG monitoring during propofol induction and maintenance of anaesthesia
39. Propofol combined with nitrous oxide-oxygen for induction and maintenance of anaesthesia
40. The effects of increasing age on thiopental disposition and anaesthetic requirements
41. Propofol (‘Dipnvan’) induction and maintenance of anaesthesia
42. Companson of infusions of propofol and methohexitone to provide light general anaesthesia during surgery with regional blockade
43. Propofol and alfentanil infusion a comparison with methohexitone and alfentanil for major surgery
44. Propofol (‘Dipnvan’) for outpatient cystoscopy efficacy and recovery compared with althesin and methohexitone
45. Dose-response relationship for disopropofol (ICI 35868, Diprivan)
46. Disposition of propofol in patients undergoing surgery
47. Use of an emulsion of ICI 35868 (propofol) for the induction and maintenance of anaesthesia
48. Companson of the effects of etomidate, thiopentone and propofol on cortisol synthesis
49. Pharmacokinetics of propofol in elderly patients
50. An investigation of the pharmacokinetic profile of propofol (‘Dipnvan’) after administration for induction and maintenance of anaesthesia by repeat bolus doses in patients having spinal anaesthetic block
51. Effect of propofol, thiopentone and etomidate on adrenal steroidogenesis in vitro
52. Recovery time and side effects following propofol infusion versus isoflurane in ENT patients with regional block
53. Etomidate and adrenocortical function
54. Influence of sedation on mortality in critically ill multiple trauma patients
55. A controlled study of the haemodynamic effects of propofol vs thiopentol during anaesthesia induction
56. Single-shot i.v. anaesthesia for outpatient dental surgery
57. Comparison of propofol with methohexitone in the provision of anaesthesia for surgery under regional blockade
58. Propofol (‘Diprivan’) for continuous intravenous anaesthesia: a comparison with methohexitone
59. Propofol for intravenous sedation
60. A study of three doses of ICI 35868 for induction and maintenance of anaesthesia
61. Sedation par propofol à debit constant cheze le traumatisé cranien
62. Comparison of induction characteristics of four intravenous anaesthetic agents
63. Premedication: effect on induction of anaesthesia with propofol
64. Dose response studies with propofol (‘Diprivan’) in unpremedicated patients
65. Has propofol an antiemetic action
66. Propofol (‘Diprivan’) infusion as main agent for day case surgery
67. Recovery from outpatient anaesthesia: a comparison of incremental propofol and propofol-isoflurane
68. Propofol or thiopentone: effects on intraocular pressure associated with induction of anaesthesia and tracheal intubation
69. Haemodynamic effects of a prolonged infusion of propofol as a supplement to nitrous oxide anaesthesia
70. The induction of anaesthesia with propofol (‘Diprivan’) compared in normal and renal failure patients
71. Propofol infusion for sedation in intensive care
72. Altered hepatic blood flow and drug disposition
73. A comparison of propofol and methohexitone as induction agents for day case isoflurane anaesthesia
74. A comparison of the haemodynamic effects of propofol (‘Diprivan’) and thiopentone in patients with coronary artery disease
75. The haemodynamic effects of propofol and thiamylal sodium for induction in coronary artery surgery
76. Effect of propofol on cerebro-spinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy
77. Autoradiographic distribution study of a short-acting anaesthetic ICI 35868
78. On the biopotency and site of action of drugs affecting endocrine tissues with special reference to the anti-steroid effect of anaesthetic agents
79. Propofol (‘Diprivan’) by intermittent bolus with nitrous oxide in oxygen for body surface operations
80. Effect of speed of injection on induction of anaesthesia using propofol
81. A comparison of propofol and methohexital for anesthesia by continuous infusion
82. Disoprivan zur Einleitung und Unterhaltung von Kurznarkosen
83. Pharmacokinetic-dynamic modelling of diprivan
84. Pharmacokinetic and pharmacodynamic modelling of propofol (‘Diprivan’) in volunteers and surgical patients
85. 2 for the maintenance of anaesthesia
86. Propofol pharmacokinetics in patients with cirrhosis
87. 14C-propofol
88. 14C-propofol (‘Diprivan’) to male volunteers
89. Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man
90. A review of the safety and tolerance of propofol (‘Diprivan’)
91. Effects of propofol on cardiovascular dynamics, myocardial blood flow and myocardial metabolism in patients with coronary artery disease
92. 2 — reaktivität der hirngefä βe beim menschen
93. The respiratory effects of propofol with and without fentanyl
94. Ventilatory effects of propofol during induction of anaesthesia: comparison with thiopentone
95. Bradycardia after propofol infusion
96. Propofol (‘Diprivan’) as a supplement to nitrous oxide-oxygen for the maintenance of anaesthesia
97. Comparison of methohexitone and propofol (‘Diprivan’) for induction of enflurane anaesthesia in outpatients
98. Propofol-fentanyl anaesthesia for coronary bypass surgery in patients with good left ventricular function
99. A comparative evaluation of propofol for the induction and maintenance of general anaesthesia
100. Inhibition of adrenal steroidogenesis by the anaesthetic etomidate
101. The new formulation of ICI 35868 (propofol) as the main agent for minor surgical procedures
102. The cardiovascular effects of propofol in patients with impaired cardiac function
103. Recovery from propofol infusion as the main agent for outpatient arthroscopy