Changing Concepts in Cancer Prevention: Limitations and Implications for Future Research in Environmental Carcinogenesis

Cancer Research

Volumn 48, Issue 6, 1988, Pages 1381-1389

  Higginson, John ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PREVENTION; CARCINOGENESIS; ENVIRONMENT; HUMAN; THEORETICAL STUDY;

CARCINOGENS, ENVIRONMENTAL; EPIDEMIOLOGY; HUMAN; NEOPLASMS; RISK FACTORS;

EID: 0023915748     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (86)

1. Higginson, J. Present trends in cancer epidemiology. Proc. Can. Cancer Conf., 8:40-75, 1968.
2. Wynder, E. L., and Gori, G. B. Contribution of the environment to cancer incidence: an epidemiologic exercise. J. Natl. Cancer Inst., 58: 825-832, 1977.
3. Higginson, J., and Muir, C. S. Environmental carcinogenesis: misconceptions and limitations to cancer control. J. Natl. Cancer Inst., 63:1291-1298,1979.
4. Doll, R., and Peto, R. The causes of cancer quantitative estimates of avoidable risks of cancer in the United States today. London: Oxford University Press, 1981.
5. Berenblum, I. Theoretical and practical aspects of the two-stage mechanism of carcinogenesis. In: A. C. Griffin and C. R. Shaw (eds.), Carcinogens: Identification and Mechanisms of Action, pp. 25-36. New York: Raven Press, 1979.
6. Weinstein, I. B., Caggori-Celli, S., Kurschneuer, P., Multistage carcinogenesis involves multiple genes and multiple mechanisms. In: Cancer Cells. The Transformed Phenotype, pp. 229–237. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1984.
7. Epstein, S. S. The Politics of Cancer. San Francisco: Sierra Club Books, 1978.
8. Ames, B. N., Magaw, R., and Gold, L. S. Ranking possible carcinogenic hazards. Science (Wash. DC), 236:271-280, 1987.
9. Berenblum, I. Chemical carcinogenesis: predictive value of carcinogenicity studies. Br. J. Cancer, 41:490-493,1980.
10. Berenblum, I. Cancer prevention as a realizable goal. In: J. G. Fortner and J. E. Rhoads (eds.), Accomplishments in Cancer Research 1980, pp. 101–104. Philadelphia: J. B. Lippincott Co., 1980.
11. Rothman, K. J. Causation and Causal Inference. In: D. Schottenfeld and J. F. Fraumeni, Jr. (eds.), Cancer Epidemiology and Prevention, pp. 15-29. Philadelphia: W. B. Saunders, 1982.
12. International Agency for Research on Cancer. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 40, pp. 1–32. Lyon, France: International Agency for Research on Cancer, 1986.
13. MacMahon, B. Epidemiological methods in cancer research. Yale J. Biol. Med., 37:508-522, 1965.
14. Harris, C. C. (ed.). Biochemical and Molecular Epidemiology of Cancer. New York: Alan R. Liss, 1986.
15. Berlin, A., Draper, M., Hemminki, K., and Vainio, H. (eds.). Monitoring Human Exposure to Carcinogenic and Mutagenic Agents. IARC Scientific Publications No. 59. Lyon, France: International Agency for Research on Cancer, 1984.
16. United States Interagency Staff Group on Carcinogens. Chemical carcinogens: a review of the science and its associated principles. Environ. Health Perspect., 67:201-282, 1986.
17. Day, N. E. Statistical considerations. In: N. J. Wald and R. Doll (eds.), Interpretation of Negative Epidemiological Evidence for Carcinogenicity. IARC Scientific Publications No. 65, pp. 13-27. Lyon, France: International Agency for Research on Cancer, 1985.
18. Wynder, E. L. Workshop on guidelines to the epidemiology of weak associations. Prev. Med., 16:139-141, 1987.
19. Roman, E., Beral, V., Carpenter, L., Watson, A., Barton, C., Ryder, H., and Aston, D. L. Childhood leukaemia in the West Berkshire and Basingstoke and North Hampshire District Health Authorities in relation to nuclear establishments in the vicinity. Br. Med. J., 294:597-602,1987.
20. Cook-Mozaffari, P. Cancer near nuclear installations. Lancet, 1: 855-856, 1987.
21. Office of Population Censuses and Surveys. Occupational Mortality. The Registrar General's Decennial Supplement for England-Wales, 1970-72. Series DS No. 1. London: Her Majesty's Stationery Office, 1978.
22. Logan, W. P. D. Cancer Mortality by Occupation and Social Class 18511971. IARC Scientific Publications No. 36. Lyon, France: International Agency for Research on Cancer, 1982.
23. Zaridze, D. G., Muir, C. S., and McMichael, A. J. Diet and cancer value of different types of epidemiological studies. In: J. V. Joossens, M. J. Hill, and J. Geboers (eds.), Diet and Human Carcinogenesis, pp. 221-233. New York: Excerpta Medica, 1985.
24. Hemminki, K., and Vainio, H. Human exposure to potentially carcinogenic compounds. In: A. Berlin, M. Draper, K. Hemminki, and H. Vainio (eds.), Monitoring Human Exposure to Carcinogenic and Mutagenic Agents. IARC Scientific Publications No. 59, pp. 37-45. Lyon, France: International Agency for Research on Cancer, 1984.
25. Committee on the Institutional Means for Assessment of Commission on Life Sciences, National Research Council. Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Academy Press, 1983.
26. Environmental Protection Agency. Guidelines for carcinogenic risk assessment, Part II. Fed. Regist., 51 (185): 33992-34003,1986.
27. Third Task Force for Research Planning in Environmental Health Sciences. Human Health and the Environment Some Research Needs. Bethesda, MD: National Institutes of Health, 1984.
28. Peto, R. Epidemiology, multistage models, and short-term mutagenicity tests. In: H. H. Hiatt, J. P. Watson, and J. A. Winsten (eds.), Origins of Human Cancer, pp. 1403-1428. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1977.
29. Beasley, R. P., Wang, L. Y., Lin, C. C., and Chien, C. S. Hepatocellular carcinoma and hepatitis B virus. Lancet, 2:1129-1133, 1981.
30. Peto, R., Parish, S. E., and Gray, R. G. There is no such thing as aging, and cancer is not related to it In: A. Likachev, V. Annisimov, and R. Montesano (eds.), Age-related Factors in Carcinogenesis. IARC Scientific Publications No. 58, pp. 43-53. Lyon, France: International Association for Research on Cancer, 1985.
31. Little, J. B. Cellular mechanisms of oncogenic transformation in vitro. In: T. Kakunaga and H. Yamasaki (eds.), Transformation Assay of Established Cell Lines: Mechanisms and Application. IARC Scientific Publications No. 67, pp. 9-29. London: Oxford University Press, 1985.
32. Klein, G., and Klein, E. Conditioned tumorigenicity of activated oncogenes. Cancer Res., 46:3211-3224, 1986.
33. Klement, V., Freedman, M. H., McAllister, R. M., Nelson-Rees, W. A., and Heubner, R. Differences in susceptibility of human cells to mouse sarcoma virus. J. Natl. Cancer Inst., 47:65-71,1971.
34. Nicholson, G. L. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res., 47:1473-1487,1987.
35. Borzsony, M., Lapis, K., Day, N. E., and Yamasaki, H. (eds.). Models, Mechanisms and Etiology of Tumour Promotion. IARC Scientific Publications No. 56. London: Oxford University Press, 1984.
36. Sachs, L. Cell differentiation and bypassing of genetic defects in the suppression of malignancy. Cancer Res., 47:1981-1986,1987.
37. National Institutes of Health Workshop Report. Cellular and molecular mechanisms for suppression and reversion of tumorigenicity: a chemical pathology study section workshop. Cancer Res., 47:2514-2520,1987.
38. Waters, M. D., Nesnow, S., Huisingh, J. L., Sandhu, S. S., and Claxton, L. (eds.). Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures. New York: Plenum Publishing Corp., 1978.
39. National Center for Toxicological Research, Society of Toxicology. A report on the workshop on biological and statistical implications of the ED0( study and related data bases. Fund. Appl. Toxicol., 3:129-160, 1983.
40. Berenblum, I. The problem of quantitative carcinogenesis. In: The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Physico-Chemical Mechanisms of Carcinogenesis, pp. 321-324. Jerusalem: Israel Academy of Sciences and Humanities, 1969.
41. Ramsey, J. C., and Gehring, P. J. Application of pharmacokinetic principles in practice. Fed. Proc., 39:60-65,1980.
42. Armstrong, B. Endocrine factors in human carcinogenesis. In: H. Bartsch, B. Armstrong, and W. David (eds.), Host Factors in Human Carcinogenesis. IARC Scientific Publications No. 39. Lyon, France: International Agency for Research on Cancer, 1982.
43. Committee on Diet, Nutrition and Cancer, National Research Council. Diet, Nutrition and Cancer. Washington, DC: National Academy Press, 1982.
44. Higginson, J. Summary: nutrition and cancer. Cancer Res., 4J(Suppl.): 2515s-2518s, 1983.
45. Jensen, O. M., MacLennan, R., and Wahrendorf, J. Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland. Nutr. Cancer, 4:5-19, 1982.
46. Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A., Hennekens, C. H., and Speizer, F. E. Dietary fat and the risk of breast cancer. N. Engl. J. Med., 316:22-28, 1987.
47. Forman, D. Gastric cancer, diet, and nitrate exposure. Br. Med. J., 294:528529, 1987.
48. Knudson, A. G., Jr. Genetics of human cancer. Annu. Rev. Genet., 20:231251, 1986.
49. Doll, R. Cancer a world-wide perspective. In: C. C. Harris (ed.), Biochemical and Molecular Epidemiology of Cancer, pp. 127-134. New York: Alan R. Liss, 1986.
50. Knudson, A. G., Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res., 45:1437-1443,1985.
51. Swift, M., Reitnauer, P. J., Morrell, D., and Chase, C. L. Breast and other cancers in families with ataxia-telangiectasia. N. Engl. J. Med., 316: 12891294, 1987.
52. Dulbecco, R. A turning point in cancer research: sequencing the human genome. Science (Wash. DC), 231:1055-1056, 1986.
53. Pickle, L. W., Mason, T. J., Howard, N., Hoover, R., and Fraumeni, J. F., Jr. Atlas of U. S. Cancer Mortality Among Whites: 1950-1980. Washington, DC: United States Department of Health and Human Services, 1987.
54. Young, J. L., Percy, C. L., and Asire, A. J. Surveillance, Epidemiology, and End Results: Incidence and Mortality Data, 1973-77. National Cancer Institute Monograph 57. Bethesda, MD: United States Department of Health and Human Services, 1981.
55. Bailar, J. C., III, and Smith, E. M. Progress against cancer? N. Engl. J. Med., 314:1226-1232,1986.
56. Grisham, J. W. Health Aspects of the Disposal of Waste Chemicals. Elms-ford, NY: Pergamon Press, 1986.
57. Higginson, J. Metabolic aspects of host environment relationships: an overview. In: R. Doll, and I. Vodopija (eds.), Host Environment Interactions in the Etiology of Cancer in Man. IARC Scientific Publications No. 7. Lyon, France: International Agency for Research on Cancer, 1973.
58. Weisburger, J. H., Cohen, L. A., and Wynder, E. L. On the etiology and metabolic epidemiology of the main human cancers, pp. 567-602. In: H. H. Hiatt, J. D Watson, and J. A. Winsten (eds.), Cold Spring Harbor Conferences on Origins of Human Cancer, Vol. 4. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1977.
59. Singer, B., and Bartsch, H. (eds). The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis. IARC Scientific Publications No. 70. Lyon, France: International Agency for Research on Cancer, 1986.
60. Harris, C. C. Human tissues and cells in carcinogenesis research. Cancer Res., 47:1-10, 1987.
61. Geyer, H., Scheunert, I., and Korte, F. Bioconcentration potential of organic environmental chemicals in humans. Regu. Toxicol. Pharmacol., 6: 313347,1986.
62. Duesberg, P. H. Retroviruses are carcinogens and pathogens: expectations and reality. Cancer Res., 47:1199-1220, 1987.
63. Perera, F. P., and Weinstein, I. B. Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J. Chronic Dis., 35:581-600,1982.
64. Bartsch, H. The role of cyclic nucleic acid base adducts in carcinogenesis and mutagenesis. In: B. Singer and H. Bartsch (eds.), The Role of Cyclic Nucleic Acid Base Adducts in Carcinogenesis and Mutagenesis. IARC Scientific Publications No. 70, pp. 3-14. Lyon, France: International Agency for Research on Cancer, 1986.
65. Bryant, M. S., Skipper, P. L., Tannenbaum, S. R., and MacLuie, M. Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers. Cancer Res., 47:602-608, 1987.
66. Haugen, A., Becher, G., Benestad, C., Vahakangas, K., Trivers, G. E., Newman, M. J., and Harris, C. C. Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke over workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Res., 46:4178-4183,1986.
67. DiGiovanni, J., Sawyer, T. W., and Fisher, E. P. Correlation between formation of a specific hydrocarbon-deoxyribonucleoside adduct and tumor-initiating activity of 7,12-dimethylbenz(a)anthracene and its 9- and 10-monofluoro derivatives in mice. Cancer Res., 46:4336-4341,1986.
68. Barnstetter, D. G., Stoner, G. D., Schut, H. A., Senitzer, D., Conran, P. B., and Goldblatt, P. J. Ethylnitrosourea-induced transplacental carcinogenesis in the mouse: tumor response, DNA binding, and adduct formation. Cancer Res., 47:348-352,1987.
69. Wild, C. P., Umbenhauer, D., Chapot, B., and Montesano, R. Monitoring of individual human exposure to aflatoxins (AF) and W-nitrosamines (NNO) by immunoassays. J. Cell. Biochem., 30:171-179,1986.
70. Jensen, D. E., Stelman, G. J., and Spiegel, A. Species differences in blood-mediated nitrosocimetidine denitrosation. Cancer Res., 47:353-359, 1987.
71. Nowell, P. C., and Croce, C. M. Chromosomes, genes and cancer. Am. J. Pathol., 725:8-15, 1986.
72. Gupta, J., Pilotta, S., Rilke, F., and Shah, K. Association of human papillomavirus type 16 with neoplastic lesions of the vulva and other genital sites by in situ hybridization. Am. J. Pathol., 127:206-215, 1987.
73. Sporn, M. B., Roberts, A. B., Wakefield, L. M., and Assoian, R. K. Transforming growth factor-0: biological function and chemical structure. Science (Wash. DC), 233: 532-534,1986.
74. Buset, M., Lipkin, M., Winawer, S., Swaroop, S., and Friedman, E. Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res., 46:5426-5430, 1986.
75. Centers for Disease Control, National Institute of Child Health and Human Development Combination oral contraceptive use and the risk of endometrial cancer. JAMA, 257:796-800, 1987.
76. Bertram, J. S., Kolonel, L. N., and Meyskens, F. L., Jr. Rationale and strategies for chemoprevention of cancer in humans. Cancer Res., 47:30123031,1987.
77. Kates, R. W. Success, strain, and surprise. Issues Sci. Technol., 3: 46-58, 1985.
78. National Research Council. Regulating Pesticides in Foods. The Delaney Paradox. Washington, DC: National Academy Press, 1987.
79. National Cancer Institute. Cancer Control Objectives for the Nation: 19852000. National Cancer Institute Monographs No. 2. Washington, DC: United States Department of Health and Human Services, 1986.
80. Food and Drug Administration. Listing of D&C Orange No. 17 for use in externally applied drugs and cosmetics. Fed. Regist, 51 (152): 28331-28364, 1986.
81. The Conservation Foundation. Risk Assessment and Risk Control. Washington, DC: The Conservation Foundation, 1985.
82. Holland, J. F. The cancer breakthrough myth. Mt Sinai J. Med., 44:674681, 1977.
83. National Panel of Consultants on the Conquest of Cancer. National Program for the Conquest of Cancer. Washington, DC: United States Government Printing Office, 1971.
84. Miller, E. C. Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential address. Cancer Res., 38:14791496, 1978.
85. Shear, M. J. Invasion of the ivory tower—The AACR faces its second half century: Presidential address. Cancer Res., 29:1319-1324, 1969.
86. Epstein, Samuel S. Losing the War Against Cancer Who's to Blame and What To Do About It-A Position Paper on the Politics of Cancer, 1987. Congressional Record E3449-E3454, 1987.