Inhaled albuterol does not protect against ozone toxicity in nonasthmatic athletes

Archives of Environmental Health

Volumn 43, Issue 1, 1988, Pages 46-53

  Gong, Henry ^a   Bedi, John F ^b   Horvath, Steven M ^b  

^a UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; OZONE; SALBUTAMOL;

ADULT; ATHLETE; BRONCHODILATATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLING; DIAGNOSIS; EPIDEMIOLOGY; ETIOLOGY; EXPERIMENT; HUMAN; HUMAN EXPERIMENT; LUNG FUNCTION; MALE; PERFORMANCE;

ADULT; AIR POLLUTANTS, ENVIRONMENTAL; ALBUTEROL; ASTHMA; BRONCHI; BRONCHIAL PROVOCATION TESTS; CONSTRICTION; DOUBLE-BLIND METHOD; EXERTION; FEMALE; HUMAN; LUNG; MALE; OZONE; PHYSICAL ENDURANCE; RANDOM ALLOCATION; RESPIRATORY FUNCTION TESTS; SUPPORT, NON-U.S. GOV'T;

EID: 0023907974     PISSN: 00039896     EISSN: None     Source Type: Journal    
DOI: 10.1080/00039896.1988.9934373     Document Type: Article

References (34)

1. Bates, D. V.; Bell, G. M.; Burham, C. D.; Hazucha, M.; Mantha, J.; Pengelly, L.; an Silverman, F. 1972. Short-term effects of ozone on the lung. J Appl Physiol 32:176-81.
2. Folinsbee, L. J.; Silverman, F.; and Shephard, R. J. 1975. Exercise responses following ozone exposure. J Appl Physiol 38: 966-1001.
3. Silverman, F.; Folinsbee, L. J.; Barnard, J.; and Shephard, R. J. 1976. Pulmonary function changes in ozone: Interaction of concentration and ventilation. J Appl Physiol 41:859-64.
4. Folinsbee, L. J.; Silverman, F.; and Shephard, R. J. 1977. Decrease in maximum work performance following ozone exposure. J Appl Physiol 42:531-36.
5. Folinsbee, L. J.; Horvath, S. M.; Raven, P. B.; Bedi, J. F.; Morton, A. R.; Drinkwater, B. L.; Bolduan, N. W.; and Gliner, J. A. 1977. Influence of exercise and heat stress on pulmonary function during ozone exposure. J Appl Physiol 43:409-13.
6. DeLucia, A. j. and Adams, W. C. 1977. Effects of 03 inhalation during exercise on pulmonary function and blood chemistry. J Appl Physiol 43:75-81.
7. Folinsbee, L. J.; Drinkwater, B. L.; Bedi, J. F.; and Horvath, S. M. 1978. The influence of exercise on the pulmonary function changes due to exposure to low concentrations of ozone. In: Environmental Stress: Individual Human Adaptations, L. J. Folinsbee, J. A. Wagner, J. F. Borgia, B. L. Drinkwater, J. A. Gliner, and J. F. Bedi, Eds., pp. 125-45. New York: Academic Press.
8. Horvath, S. M.; Gliner, J. A.; and Matsen-Twisdale, J. A. 1979. Pulmonary function and maximum exercise responses following acute ozone exposure. Aviat Space Environ Med 50:901-05.
9. Adams, W. C.; Savin, W. M.; and Christo, A. E. 1981. Detection of ozone toxicity during continuous exercise via the effective dose concept. J Appl Physiol 51:415-22.
10. McDonnell, W. F.; Horstman, D. H.; Hazucha, M. J.; Seal, E., Jr.; Haak, E. D.; Salaam, S. A.; and House, D. E. 1983. Pulmonary effects of ozone exposure during exercise: Dose-response characteristics. J Appl Physiol 54:1345-52.
11. Adams, W. C. and Schelegle, E. S. 1983. Ozone and high ventilation effects on pulmonary function and endurance performance. J Appl Physiol 55:805-12.
12. Gibbons, S. I. and Adams, W. C. 1984. Combined effects of ozone exposure and ambient heat on exercising females. J Appl Physiol 57:450-56.
13. Folinsbee, L. J.; Bedi, J. F.; and Horvath, S. M. 1984. Pulmonary function changes after 1h continuous heavy exercise in 0.21 ppm ozone. J Appl Physiol 57:984-88.
14. Avol, E. L.; Linn, W. S.; Venet, T. G.; Shamoo, D. A.; and Hackney, J. F. 1984. Comparative respiratory effects of ozone and ambient oxidant pollution exposure during heavy exercise. J Air Pollut Control Assoc 34:804-09.
15. Kulle, T. J.; Sauder, L. R.; Hebel, J. R.; and Chatham, M. D. 1985. Ozone response relationships in healthy nonsmokers. Am Rev Respir Dis 132:36-41.
16. Gong, H., Jr.; Bradley, P. W.; Simmons, M. S.; and Tashkin, D. P. 1986. Impaired exercise performance and pulmonary function in elite cyclists during low-level ozone exposure in a hot environment. Am Rev Respir Dis 134:726-33.
17. Schelegle, E. S. and Adams, W. C. 1986. Reduced exercise time in competitive simulations consequent to low level ozone exposure. Med Sci Sports Exerc 18:408-14.
18. Wayne, W. S.; Wehrle, P. F.; and Carroll, R. E. 1967. Oxidant air pollution and athletic performance. JAMA 199:151-54.
19. Foxcroft, W. J. and Adams, W. C. 1986. Effects of ozone exposure on four consecutive days on work performance and V°2max-1 APPL Physiol 61:960-66.
20. Bromberg, P. A. and Hazucha, M. J. 1982. Is adaptation to ozone protective? Am Rev Respir Dis 125:489-90.
21. Avol, E. L.; Linn, W. S.; Wightman, L. H.; Homer, J. E.; and Hackney, J. D. 1982. Laboratory evaluation of a disposable halfface mask for protection against ozone. Am Rev Respir Dis 126:818-21.
22. Chatham, M. D.; Sauder, L. R.; and Kulle, T. J. 1984. Evaluation of the effect of vitamin C on ozone-induced bronchoconstriction in normal subjects. Am Rev Respir Dis 129.A145.
23. Hackney, J. D.; Linn, W. S.; Buckley, R. D.; Jones, M. P.; Wightman, L. H.; and Karuza, S. K. 1981. Vitamin E supplementation and respiratory effects of ozone in humans. J Toxicol Environ Health 7:383-90.
24. O’Bryne, P. M.; Walters, E. H.; Aizawa, H.; Fabbri, L. M.; Holtzman, M. J.; and Nadel, J. A. 1984. Indomethacin inhibits the airway responsiveness but not the neutrophil influx induced by ozone in dogs. Am Rev Respir Dis 130:220-24.
25. Fabbri, L. M.; Aizawa, H.; O’Bryne, P. M.; Bethel, R. A.; Walters, E. H.; Holtzman, M. J.; and Nadel, J. A. 1985. An antiinflammatory drug (BW755C) inhibits airway responsiveness induced by ozone in dogs. J Allergy Clin Allergy 76:162-66.
26. Holtzman, M. J.; Cunningham, J. H.; Sheller, J. R.; Irsigler, G. B.; Nadel, J. A.; and Boushey, H. A. 1979. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects. Am Rev Respir Dis 120:1059-67.
27. Beckett, W. S.; McDonnell, W. F.; Horstman, D. H.; and House, D. E. 1985. Role of the parasympathetic nervous system in acute lung response to ozone. J Appl Physiol 59:1879-85.
28. Fitch, K. D. 1986. The use of anti-asthmatic drugs. Do they affect sports performance? Sports Med 3:136-50.
29. Sly, R. M. 1984. Beta-adrenergic drugs in the management of asthma in athletes. J Allergy Clin Immunol 73:680-85.
30. Koenig, J. Q.; Marshall, S. C.; Horike, M.; Shapiro, C. G.; Furukawa, C. T.; Bierrnan, C. W.; and Pierson, W. E. 1987. The effects of albuterol on sulfur dioxide-induced bronchoconstriction in allergic adolescents. J Allergy Clin Immunol 79:54-58.
31. Sidney, K. H. and Lefcoe, N. M. 1977. The effects of ephedrine on the physiological and psychological responses to submaximal and maximal exercise in man. Med Sci Sports 9:95-99.
32. McKenzie, D. C.; Rhodes, E. C.; Stirling, D. R.; Wiley, J. P.; Dunwoody, D. W.; Filsinger, I. B.; Jang, F.; and Stevens, A. 1983. Salbutamol and treadmill performance in non-atopic athletes. Med Sci Sports Exerc 15:520-22.
33. Barnes, P. J. 1986. Neural control of human airways in health and disease. Am Rev Respir Dis 134:1289-314.
34. Howarth, P. H.; Durham, S. R.; Lee, T. H.; Kay, B.; Church, M. K; and Holgate, S. T. 1985. Influence of albuterol, cromolyn sodium, and ipratropium bromide on the airway and circulatory mediator responses to allergen bronchial provocation in asthma. Am Rev Respir Dis 132:986-92.