Prevention of Necrotizing Enterocolitis in Low-Birth-Weight Infants by IgA–IgG Feeding

New England Journal of Medicine

Volumn 319, Issue 1, 1988, Pages 1-7

  Eibl, Martha M ^a   Wolf, Hermann M ^a   Fürnkranz, Heinz ^b   Rosenkranz, Alfred ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b Children's Hospital Glanzing   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

HUMAN; INFANT; LOW BIRTH WEIGHT; NECROTIZING ENTEROCOLITIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0023902592     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198807073190101     Document Type: Article

References (50)

1. Santulli TV, Schullinger JN, Heird WC, et al. Acute necrotizing enterocolitis in infancy: a review of 64 cases. Pediatrics 1975; 55: 376–87.
2. Brown EG, Sweet AY. Neonatal necrotizing enterocolitis. Pediatr Clin North Am 1982; 29: 1149–70.
3. Kliegman RM, Fanaroff AA. Necrotizing enterocolitis. N Engl J Med 1984; 310: 1093–103.
4. Kosloske AM. Pathogenesis and prevention of necrotizing enterocolitis: a hypothesis based on personal observation and a review of the literature. Pediatrics 1984; 74: 1086–92.
5. Speer ME, Taber LH, Yow MD, Rudolph AJ, Urteaga J, Waller S. Fulminant neonatal sepsis and necrotizing enterocolitis associated with a “nonenteropathogenic” strain of Escherichia coli. J Pediatr 1976; 89: 91–5.
6. Cushing AH. Necrotizing enterocolitis with Escherichia coli heat-labile enterotoxin. Pediatrics 1983; 71: 626–30.
7. Hill HR, Hunt CE, Matsen JM. Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive-care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitis. J Pediatr 1974; 85: 415–9.
8. Powell J, Bureau MA, Paré C, Gaildry M-L, Cabana D, Patriquin H. Necrotizing enterocolitis: epidemic following an outbreak of Enterobacter cloacae type 3305573 in a neonatal intensive care unit. Am J Dis Child 1980; 134: 1152–4.
9. Henderson A, Maclaurin J, Scott JM. Pseudomonas in a Glasgow baby unit. Lancet 1969; 2: 316–7.
10. Engel R. Necrotizing enterocolitis in the newborn: report of 68th Ross Conference on Pediatric Research. Columbus, Ohio: Ross Laboratories, 1974:66–71.
11. Han VKM, Sayed H, Chance GW, Brabyn DG, Shaheed WA. An outbreak of Clostridium difficile necrotizing enterocolitis: a case for oral vancomycin therapy? Pediatrics 1983; 71: 935–41.
12. Cashore WJ, Peter G, Lauermann M, Stonestreet BS, Oh W. Clostridia colonization and clostridial toxin in neonatal necrotizing enterocolitis. J Pediatr 1981; 98: 308–11.
13. Howard FM, Flynn DM, Bradley JM, Noone P, Szawatkowski M. Outbreak of necrotising enterocolitis caused by Clostridium butyricum. Lancet 1977; 2: 1099–102.
14. Kosloske AM, Ulrich JA, Hoffman H. Fulminant necrotising enterocolitis associated with Clostridia. Lancet 1978; 2: 1014–6.
15. Rotbart HA, Levin MJ, Yolken RH, Manchester DK. An outbreak of rotavirus-associated neonatal necrotizing enterocolitis (NEC). Pediatr Res 1983; 17: 333A. abstract.
16. Resta S, Luby JP, Rosenfeld CR, Siegel JD. Isolation and propagation of a human enteric Coronavirus. Science 1985; 229: 978–81.
17. Egan EA, Mantilla G, Nelson RM, Eitzman DV. A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis. J Pediatr 1976; 89: 467–70.
18. Bell MJ, Shackelford PG, Feigin RD, Ternberg JL, Brotherton T. Alterations in gastrointestinal microflora during antimicrobial therapy for necrotizing enterocolitis. Pediatrics 1979; 63: 425–8.
19. Grylack LJ, Scanlon JW. Oral gentamicin therapy in the prevention of neonatal necrotizing enterocolitis: a controlled double-blind trial. Am J Dis Child 1978; 132: 1192–4.
20. Boyle R, Nelson JS, Stonestreet BS, Peter G, Oh W. Alterations in stool flora resulting from oral kanamycin prophylaxis of necrotizing enterocolitis. J Pediatr 1978; 93: 857–61.
21. Rowley MP, Dahlenburg GW. Gentamicin in prophylaxis of neonatal necrotising enterocolitis. Lancet 1978; 2: 532.
22. Barnes GL, Doyle LW, Hewson PH, et al. A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet 1982; 1: 1371–3.
23. Stoliar OA, Pelley RP, Kaniecki-Green E, Klaus MH, Carpenter CCJ. Secretory IgA against enterotoxins in breast-milk. Lancet 1976; 1: 1258–61.
24. Williams RC, Gibbons RJ. Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal. Science 1972; 177: 697–9.
25. van Furth R, Leijh PCJ, Klein F. Correlation between opsonic activity for various microorganisms and composition of gammaglobulin preparations for intravenous use. J Infect Dis 1984; 149: 511–7.
26. Schroeder DD, Mozen MM. Australia antigen: distribution during Cohn ethanol fractionation of human plasma. Science 1970; 168: 1462–4.
27. Blum PM, Phelps DL, Ank BJ, Krantman HJ, Stiehm ER. Survival of oral human immune serum globulin in the gastrointestinal tract of low birth weight infants. Pediatr Res 1981; 15: 1256–60.
28. Kliegman RM, Fanaroff AA. Neonatal necrotizing enterocolitis: a nine-year experience. I. Epidemiology and uncommon observations. Am J Dis Child 1981; 135: 603–7.
29. Stoll BJ, Kanto WP Jr, Glass RI, Nahmias AJ, Brann AW Jr. Epidemiology of necrotizing enterocolitis: a case control study. J Pediatr 1980; 96: 447–51.
30. Bunton GL, Durbin GM, McIntosh N, et al. Necrotizing enterocolitis: controlled study of 3 years' experience in a neonatal intensive care unit. Arch Dis Child 1977; 52: 772–7.
31. Hopkins GB, Gould VE, Stevenson JK, Oliver TK Jr. Necrotizing enterocolitis in premature infants. Am J Dis Child 1970; 120: 229–32.
32. Touloukian RJ, Posch JN, Spencer R. The pathogenesis of ischemic gastroenterocolitis of the neonate: selective gut mucosal ischemia in asphyxiated neonatal piglets. J Pediatr Surg 1972; 7: 194–205.
33. Ostertag SG, LaGamma EF, Reisen CE, Ferrentino FL. Early enterai feeding does not affect the incidence of necrotizing enterocolitis. Pediatrics 1986; 77: 275–80.
34. Book LS, Herbst JJ, Jung AL. Comparison of fast- and slow-feeding rate schedules to the development of necrotizing enterocolitis. J Pediatr 1976; 89: 463–6.
35. Goldman HI. Feeding and necrotizing enterocolitis. Am J Dis Child 1980; 134: 553–5.
36. Lehmiller DJ, Kanto WP Jr. Relationships of mesenteric thromboembolism, oral feeding, and necrotizing enterocolitis. J Pediatr 1978; 92: 96–100.
37. Welsh JK, May JT. Anti-infective properties of breast milk. J Pediatr 1979; 94: 1–9.
38. Glass RI, Svennerholm A-M, Stoll BJ, et al. Protection against cholera in breast-fed children by antibodies in breast milk. N Engl J Med 1983; 308: 1389–92.
39. Jason JM, Nieburg P, Marks JS. Mortality and infectious disease associated with infant-feeding practices in developing countries. Pediatrics 1984; 74: Suppl: 702–27.
40. Narayanan I, Prakash K, Bala S, Verma RK, Gujral VV. Partial supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants. Lancet 1980; 2: 561–3.
41. Pitt J, Barlow B, Heird WC. Protection against experimental necrotizing enterocolitis by maternal milk. I. Role of milk leukocytes. Pediatr Res 1977; 11: 906–9.
42. Barlow B, Santulli TV, Heird WC, Pitt J, Blanc WA, Schullinger JN. An experimental study of acute neonatal enterocolitis — the importance of breast milk. J Pediatr Surg 1974; 9: 587–95.
43. Mizrahi A, Barlow O, Berdon W, Blanc WA, Silverman WA. Necrotizing enterocolitis in premature infants. J Pediatr 1965; 66: 697–706.
44. Narayanan I, Prakash K, Murthy NS, Gujral VV. Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection. Lancet 1984; 2: 1111–3.
45. Ford JE, Law BA, Marshall VME, Reiter B. Influence of the heat treatment of human milk on some of its protective constituents. J Pediatr 1977; 90: 29–35.
46. Kliegman RM, Pittard WB, Fanaroff AA. Necrotizing enterocolitis in neonates fed human milk. J Pediatr 1979; 95: 450–3.
47. Yolken RH, Losonsky GA, Vonderfecht S, Leister F, Wee S-B. Antibody to human rotavirus in cow's milk. N Engl J Med 1985; 312: 605–10.
48. Hanson LÅ. The mammary gland as an immunological organ. Immunol Today 1982; 3: 168–72.
49. Lindh E. Increased resistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component. J Immunol 1975; 114: 284–6.
50. Soothill JF. Immunological aspects of infant feeding. In: Soothill JF, Hayward AR, Wood CBS, eds. Paediatric immunology. Oxford: Blackwell, 1983:110–29.