Pharmacokinetic and pharmacodynamic comparison of a new controlled-release formulation of metoprolol with a traditional slow-release formulation

European Journal of Clinical Pharmacology

Volumn 33, Issue 1 Supplement, 1988, Pages

  Oosterhuis, B ^a   Jonkman, J H G ^a   Kerkhof, F A ^a  

^a PRA International USA   (Netherlands)

Author keywords

controlled release formulation; exercise heart rate; metoprolol; plasma concentration profile; slow release formulation

Indexed keywords

METOPROLOL; METOPROLOL TARTRATE;

ADULT; CONTROLLED STUDY; EXERCISE; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

ADULT; BLOOD PRESSURE; COMPARATIVE STUDY; DELAYED-ACTION PREPARATIONS; EXERTION; HEART RATE; HUMAN; MALE; METOPROLOL;

EID: 0023902112     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/BF00578407     Document Type: Article

References (6)

1. Pharmacokinetic studies on the selective β1-receptor antagonist metoprolol in man
2. Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic β1-receptor antagonist metoprolol
3. Oxidation phenotype — A major determinant of metoprolol metabolism and response
4. Development of a new controlled release metoprolol product
5. Determination of metoprolol in plasma and urine using high-resolution gas-chromatography and electron-capture detection
6. Biopharmaceutic considerations in designing and evaluating novel drug delivery systems