The relationship between inhibition of vitamin K1 2,3‐epoxide reductase and reduction of clotting factor activity with warfarin.

British Journal of Clinical Pharmacology

Volumn 25, Issue 1, 1988, Pages 1-7

  Choonara, IA ^a   Malia, RG ^a   Haynes, BP ^a   Hay, CR ^a   Cholerton, S ^a   Breckenridge, AM ^a   Preston, FE ^a   Park, BK ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; PHYTOMENADIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); WARFARIN;

DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PROTHROMBIN TIME; VITAMIN METABOLISM; VOLUNTEER;

BLOOD COAGULATION FACTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; MIXED FUNCTION OXYGENASES; PROTHROMBIN TIME; SUPPORT, NON-U.S. GOV'T; WARFARIN;

EID: 0023899986     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1988.tb03274.x     Document Type: Article

References (26)

1. Metabolism of vitamin K and prothrombin synthesis: anticoagulants and the vitamin K‐epoxide cycle
2. Warfarin and the inhibition of vitamin K activity by an oxide metabolite
3. Response of protein C and protein C inhibitor to warfarin therapy in patient with combined deficiences of factors V and VIII
4. Standardisation of the one stage prothrombin time for the control of anticoagulant therapy
5. Immunoassays of human prothrombin species which correlate with functional coagulant activities
6. A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4‐hydrocycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit
7. 1 metabolism in relation to pharmacodynamic response in anticoagulated patients
8. Radioimmunoassays for protein C and factor X. Plasma antigen levels in abnormal haemostatic states
9. Evidence that warfarin anticoagulant action involves two distinct reductase activities
10. Comparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy
11. Deficiency of protein C in congenital thrombotic disease
12. In
13. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies
14. Evidence against vitamin K deficiency in normal neonates
15. Studies on immunological assay of vitamin K dependent factors. (II) Comparison of four immunoassay methods with functional activity of protein C in human plasma
16. Diuretics and other agents employed in the mobilisation of edema fluid
17. A pharmacokinetic program for the TI‐59
18. 1 metabolism and prothrombin complex activity in the rabbit
19. 1 in relation to anticoagulant poisoning
20. Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4‐hydroxycoumarins
21. Relationship of dithiothreitol‐dependent microsomal vitamin K quinone and vitamin K epoxide reductases. Inhibition of epoxide reduction by vitamin K quinone
22. 1): dose‐response relationships in man
23. Vitamin K‐dependent formation of γ‐carboxyglutamic acid
24. Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy
25. Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat
26. 1 2, 3‐epoxide in rabbit plasma by high performance liquid chromatography