Acceptable daily intake: Inception, evolution, and application

Regulatory Toxicology and Pharmacology

Volumn 8, Issue 1, 1988, Pages 45-60

  Lu, Frank C ^a  

^a Food Additives Contaminants and Environmental Chemicals Miami Florida 33116 0916 USA ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD ADDITIVE; PESTICIDE;

FOOD CONTAMINATION; HUMAN;

ANIMAL; BODY SURFACE AREA; BODY WEIGHT; CATS; CATTLE; DOGS; FOOD ADDITIVES; GUINEA PIGS; HUMAN; MICE; RABBITS; RATS; SPECIES SPECIFICITY; WORLD HEALTH ORGANIZATION;

EID: 0023899734     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/0273-2300(88)90006-2     Document Type: Article

References (42)

1. Delayed neurotoxicity from continuous low dose administration of leptophos to hens
2. New risk assessment initiatives in EPA
3. Reconsideration of the dilemma of DDT for the establishment of an acceptable daily intake
4. New approaches to the derivation of acceptable daily intake (ADI)
5. Regulatory history and experimental support of uncertainty (safety) factors
6. Guidelines and methodology used in the preparation of health effects assessment chapters of the consent decree water quality criteria
7. Integrated Risk Information System (IRIS)
8. Pesticide Residues in Food
9. Marked potentiation in mammalian toxicity from simultaneous administration of two anticholinesterase compounds
10. Estimation of risks of irreversible, delayed toxicity
11. Delayed neurotoxic action of some organophosphorus compounds
12. Evaluation of safety: Toxicological evaluation
13. 100-fold margin of safety
14. Thalidomide embryopathy
15. The Joint FAO/WHO Food Standards Program and the Codex Alimentarious
16. Toxicological evaluation of carcinogens and noncarcinogens: Pros and cons of different approaches
17. Safety assessments of chemicals with thresholded effects
18. Risk assessment and regulatory decision making
19. The use of quantal response data to make predictions
20. Resolution WHA 6.16
21. Procedures for the testing of intentional food additives to establish their safety for use
22. Evaluation of the carcinogenic hazards of food additives
23. Evaluation of the toxicity of a number of antimicrobials and antioxicants
24. Principles governing consumer safety in relation to pesticide residues
25. Specifications for the identity and purity of food additives and their toxicological evaluation: Some emulsifiers and stabilizers and certain other substances
26. Procedures for investigating intentional and unintentional food additives
27. Principles for the testing of drugs for teratogenicity
28. Specifications for the identity and purity of food additives and their toxicological evaluation: Some flavouring substances and non-nutritive sweetening agents
29. Principles for the testing and evaluation of drugs for carcinogenicity
30. Pesticide residues in food
31. Specifications for the identity and purity of food additives and their toxicological evaluation: Some food colours, emulsifiers, stabilizers, anticaking agents, and certain other substances
32. Evaluation and testing of drugs for mutagenicity: Principles and problems
33. Evaluation of food additives: Specifications for the identity and purity of food additives and their toxicological evaluation: Some extraction solvents and certain other substances; and a review of the technological efficacy of some antimicrobial agents
34. Toxicological evaluation of certain food additives with a review of general principles and of specifications
35. Pesticide residues in food
36. Evaluation of certain food additives and contaminants
37. Organophosphorus insecticides: A general introduction
38. Evaluation of certain food additives and contaminants
39. The no-effect level, an old bone of contention in toxicology