Lesion localisation: Implications for the study of functional effects and mechanisms of action

Toxicology

Volumn 49, Issue 1, 1988, Pages 131-136

  Cavanagh, J B ^a,b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Energy deprivation; Nitroimidazoles; Nitroreduction; Thiamine deficiency; Wernicke

Indexed keywords

3 ACETYLPYRIDINE; 6 AMINONICOTINAMIDE; FURALTADONE; METRONIDAZOLE; MISONIDAZOLE;

ENERGY DEPRIVATION; HUMAN; LEIGH DISEASE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; REDUCTION; SHORT SURVEY; THIAMINE DEFICIENCY; WERNICKE ENCEPHALOPATHY;

ANIMAL; ENERGY METABOLISM; HUMAN; NIACINAMIDE; NITRO COMPOUNDS; PERIPHERAL NERVOUS SYSTEM DISEASES; WERNICKE ENCEPHALOPATHY;

EID: 0023897451     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(88)90184-9     Document Type: Article

References (11)

1. Mechanism of damage by chemical agents
2. Thiamine content and turnover rates of some rat nervous regions using labelled thiamine as tracer
3. Histochemical and biochemical approaches to axoplasmic transport of thiamine
4. Wernicke's Disease: a clinical and pathological study of 42 cases
5. Effects of thiamine deficiency on the nervous system
6. Ultrastructural features of early brain stem lesions of thiamine-deficient rats
7. Acute gliopathy in spinal cord and brain stem induced by 6-aminonicotinamide
8. Effects of 3-acetylpyridine on the central nervous system of the rat as demonstrated by silver methods
9. Anti-metabolic action on the pentose phosphate pathway in the central nervous system induced by 6-aminonicotinamide
10. Functional disorders of the brain induced by synthesis of nucleotides containing 3-acetylpyridine
11. Metabolic reduction of 4-Nitroquinoline N-oxide and other radical producing drugs to oxygen-reactive intermediates