Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

Nature

Volumn 333, Issue 6168, 1988, Pages 93-96

  Davidson, Howard W ^a,b   Rhodes, Christopher J ^a   Hutton, John C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Department of Biochemistry   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROINSULIN;

ANIMAL CELL; CALCIUM CELL LEVEL; GOLGI COMPLEX; INSULIN SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CALCIUM; CYTOPLASMIC GRANULES; ENDOPEPTIDASES; HYDROGEN-ION CONCENTRATION; IN VITRO; ISLETS OF LANGERHANS; KINETICS; PROINSULIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0023895049     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/333093a0     Document Type: Article

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