Gene products which play a role in cancer invasion and metastasis

Breast Cancer Research and Treatment

Volumn 11, Issue 2, 1988, Pages 113-124

  Liotta, Lance A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

autocrine factors; basement membrane; collagenase; extracellular matrix; growth factors; integrins; invasion; laminin receptors; metastasis; oncogenes; ras

Indexed keywords

GROWTH FACTOR;

BASEMENT MEMBRANE; BREAST CANCER; CANCER; FEMALE; HUMAN; METASTASIS; ONCOGENE; REVIEW;

BREAST NEOPLASMS; CELL MOVEMENT; EXTRACELLULAR MATRIX; GENES, RAS; HUMAN; IN VITRO; LAMININ; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; ONCOGENES;

EID: 0023893386     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/BF01805835     Document Type: Article

References (61)

1. Patterns of metastasis in human malignancies
2. Cancer metastasis: Experimental approaches, theoretical concepts, and impacts for treatment strategies
3. Tumor invasion and metastases — role of the extracellular matrix: Rhoads Memorial Award Lecture
4. Loss of basement membrane components by invasive tumors but not their benign counterparts
5. Laminin and fibronectin in rectal adenocarcinoma: Relationship to tumor grade, stage and metastasis
6. Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin
7. Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment
8. Shapes, domain, organization, and flexibility of laminin and fibronectin, two multifunctional proteins of the ECM
9. Laminin molecular domains which alter metastasis in a murine model
10. Integrins: A family of cell surface receptors
11. Editorial: Critical factors controlling angiogenesis: Cell products, cell matrix, and growth factors
12. Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro
13. Role of collagenases in tumor cell invasion
14. Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein
15. A gene for rabbit synovial cell collagenase: Member of a family of metalloproteinases that degrade the connective tissue matrix
16. Collagenase in human head and neck tumors and rat tumors and fibroblasts in monolayer cultures
17. Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase
18. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
19. Cysteine proteinases and metastasis
20. Oncogenes of spontaneous and chemically induced tumors
21. Oncogenes and proto-oncogenes: How do they differ?
22. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
23. Tumor cell instability, diversification, and progression to the metastatic phenotype: From oncogene to oncofetal expression
24. NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice
25. Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell
26. Experimental metastatic ability of H- ras transformed NIH-3T3 cells
27. Tumorigenic and metastatic properties of ‘normal’ and ras-transfected NIH/3T3 cells
28. Expression of H- ras correlates with metastatic potential: Evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells
29. Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c-Ha- ras-1 gene
30. Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection
31. Invasive and metastatic potential induced by ras-transfection into mouse BW5147 T-lymphoma cells
32. Karyotypic analysis of diploid or near diploid metastatic Harvey ras transformed rat embryo fibroblasts
33. Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials
34. N-nitroso-methylurea as a mammary gland carcinoma in rats
35. Induction of mammary carcinomas in rats by NMU involves malignant activation of Ha- ras-1 locus by a single point mutation
36. Secretion of type IV collagenolytic protease and metastatic phenotype: Induction by transfection with c-Ha- ras but not c-Ha- ras plus Ad2-E1a
37. β1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis
38. Tumor cell autocrine motility factor
39. Ras-transformed cells: Altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites
40. Transformation by oncogenes encoding protein kinases induces the metastatic phenotype
41. Requirement for c- ras proteins during viral oncogene transformation
42. The v- mos and H- ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR
43. The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes
44. Proto-oncogene abnormalities in human breast cancer: Correlations with anatomic features and clinical course of disease
45. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
46. Oncogenes give breast cancer prognosis
47. Amplification of the neu (c- erbB-2) oncogene in human mammary tumors is relatively frequent and is often accompanied by amplification of the linked c- erbA oncogene
48. Comparative study of Harvey- ras oncogene expression with conventional clinicopathologic parameters of breast cancer
49. Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer
50. Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas
51. Elevated ras oncogene expression correlates with lymph node metastases in breast cancer patients
52. Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation
53. Association of multiple copies of the N- myc oncogene with rapid progression of neuroblastomas
54. Amplification of N- myc in untreated human neuroblastomas correlates with advanced disease stage
55. Human small-cell lung cancers show amplification and expression of the N- myc gene
56. Expression of the c- myc gene in human gastrointestinal malignancies
57. The chemotactic response of tumor cells: A model for cancer metastasis
58. Stimulation of haptotaxis and migration of tumor cells by serum spreading factor
59. Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells
60. Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration