Age and the antihypertensive effect of aspirin in rats

British Journal of Pharmacology

Volumn 94, Issue 3, 1988, Pages 755-758

  Tuttle, Richard S ^a   Yager, Janice ^a   Northrup, Nicole ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; PROSTAGLANDIN F2 ALPHA;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE; HYPERTENSION; KIDNEY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

AGING; ANIMAL; ANTIHYPERTENSIVE AGENTS; ASPIRIN; DINOPROST; KIDNEY; MALE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SUPPORT, NON-U.S. GOV'T;

EID: 0023889144     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1988.tb11585.x     Document Type: Article

References (12)

1. Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism
2. Mechanism of the anti‐platelet activity of the beta‐receptor antagonists
3. The effect of salt and meclofenamate administration on the hypertension of spontaneously hypertensive rats
4. Renal functional and organic changes induced by salt and prostaglandin inhibition in spontaneously hypertensive rats
5. Modification of anti‐hypertensive effect of 3 adrenoceptor‐blocking agents by inhibition of endogenous prostaglandin synthesis
6. Prostaglandins: their disappearance from and release into the circulation
7. Influence of indomethacin and clidanac on the blood pressure lowering effect of beta blockers
8. Interference by B‐adrenergic blocking agents, with the anti‐inflammatory action of various drugs
9. Increase in experimental hypertension following inhibition of prostaglandin biosynthesis
10. Inhibition by metoprolol of the antihypertensive effect of aspirin in young rats
11. Dose dependent anti‐hypertensive effect of aspirin in the SHR.
12. Failure of chronic aspirin treatment to inhibit urinary prostaglandin excretion in spontaneously hypertensive rats: Comparison with indomethacin and flurbiprofen