Oxygen-derived free radicals and postischemic myocardial dysfunction ("stunned myocardium")

Journal of the American College of Cardiology

Volumn 12, Issue 1, 1988, Pages 239-249

  Bolli, Roberto ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; FREE RADICAL; OXYGEN RADICAL; SUPEROXIDE DISMUTASE;

COMPLICATION; CORONARY REPERFUSION; HEART INFARCTION; HUMAN; PRIORITY JOURNAL; SHORT SURVEY;

ANIMAL; CORONARY DISEASE; FREE RADICALS; HUMAN; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXYGEN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023887809     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(88)90381-6     Document Type: Review

References (76)

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6. Studies of experimental coronary artery reperfusion: effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage
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10. The stunned myocardium: prolonged, postischemic ventricular dysfunction
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13. Reduction of sympathetic inotropic response after ischemia in dogs
14. 2+ transport in the post-ischemic “stunned” myocardium (abstr)
15. Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium
16. Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional (“stunned”) but viable myocardium
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18. Depression of action potential characteristics and a decreased space constant are present in postischemic, reperfused myocardium
19. Validation of a single crystal for measurement of transmural and epicardial thickening
20. Disparity of epicardial and endocardial function during ischemia and reperfusion (abstr)
21. Nonuniform transmural response of the “stunned” myocardium to inotropic stimulation (abstr)
22. Delayed recovery of regional diastolic function following reversible ischemia in conscious dogs (abstr)
23. Dissociation between global and regional systolic and diastolic ventricular function during coronary occlusion and reperfusion
24. Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart
25. Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers
26. Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration
27. Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation
28. Selective enhancement of function of stunned myocardium by increased flow
29. Reversibly injured, postischemic canine myocardium retains normal contractile reserve
30. Oxygen-derived free radicals in postischemic tissue injury
31. The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis
32. Free radicals and myocardial injury: pharmacologic implications
33. Canine myocardial reperfusion injury: its reduction by the combined administration of superoxide dismutase and catalase
34. Xanthine oxidase as a source of free radical damage in myocardial ischemia
35. Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia
36. N-2-mercaptopropionylglycine improves recovery of myocardial function following reversible regional ischemia
37. Neutrophil depletion fails to attenuate postischemic myocardial dysfunction (abstr)
38. Attenuation of dysfunction in the postischemic “stunned” myocardium by dimethylthiourea
39. Evidence for a pathogenetic role of xanthine oxidase in the “stunned” myocardium
40. The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction
41. Lipoxygenase inhibitor nafazatrom fails to attenuate postischemic ventricular dysfunction
42. Superoxide dismutase plus catalase improve contractile function in the canine model of the “stunned” myocardium
43. Beneficial actions of Superoxide dismutase and catalase in stunned myocardium of dogs
44. Effect of intracoronary superoxide dismutase on regional myocardial function after brief periods of ischemia (abstr)
45. Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea
46. Enhancement of postischemic metabolic and functional recovery in the stunned canine myocardium by desferrioxamine (DF) (abstr)
47. Oxygen toxicity. oxygen radicals, transition metals and disease
48. Depression of contractility in isolated rabbit myocardium following exposure to iron: role of free radicals
49. Inhibition of the ironcatalysed formation of hydroxyl radicals from superoxide and lipid peroxidation by desferrioxamine
50. Myocardial tissue iron delocalization and evidence for lipid peroxidation after two hours of ischemia (abstr)
51. Post-resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest
52. Myocardial alterations due to freeradical generation
53. Influence of exogenously generated oxidant species on myocardial function
54. 2 free radical-mediated myocardial and vascular dysfunction
55. Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum: participation of the cyclooxygenase pathway
56. In vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury
57. Conjugated dienes in ischemic and reperfused myocardium an in vivo chemical signature of oxygen free radical mediated injury
58. Oxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion
59. Free radical-producing enzyme xanthine oxidase is undetectable in human hearts
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63. Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog
64. Direct measurement of free radical generation following reperfusion of ischemic myocardium
65. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy
66. Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production
67. Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO
68. Identification of transient and persistent segmental wall motion abnormalities in patients with unstable angina by two-dimensional echocardiography
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74. Delayed recovery of severely “stunned” myocardium with the support of a left ventricular assist device after coronary artery bypass graft surgery