Solid phase extraction chromatography and NMR spectroscopy (SPEC-NMR) for the rapid identification of drug metabolites in urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 6, Issue 2, 1988, Pages 151-165

  Wilson, Ian D ^a   Nicholson, J K ^b  

^a Hoechst Pharmaceutical Research Laboratories   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

drug metabolite identification; high resolution proton NMR; solid phase extraction; SPEC NMR.; Urinalysis

Indexed keywords

ACETYLSALICYLIC ACID; DRUG METABOLITE; IBUPROFEN; NAPROXEN; PARACETAMOL; PENTOXIFYLLINE;

DRUG IDENTIFICATION; DRUG MIXTURE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; URINE;

EID: 0023887138     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0731-7085(88)80041-4     Document Type: Article

References (21)

1. Proton magnetic resonance spectroscopy of human urine: Excretion of 1-(3′-carboxypropyl)-3,7-dimethylxanthine by man after dosing with oxpentifylline
2. A rapid method for the isolation and identification of drug metabolites from human urine using solid phase extraction and proton NMR spectroscopy
3. Spin-echo proton NMR spectroscopy of urine samples. Water suppression via a urea-DependentT2 relaxation process
4. Nuclear magnetic resonance detection for the on-line identification of liquid chromatography eluents