Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications

Journal of Controlled Release

Volumn 7, Issue 1, 1988, Pages 1-24

  Banga, Ajay K ^a   Chien, Yie W ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DELIVERY SYSTEM; ELECTRODE; HUMAN; IONTOPHORESIS; METHODOLOGY; PRIORITY JOURNAL; REVIEW; TOPICAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0023885550     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(88)90075-2     Document Type: Review

References (226)

1. Therapeutic action of constant current
2. Introduction of medicinal substances into the depth of tissues by electric current
3. Iontophoresis
4. Electrical Stimulation and iontophoresis
5. Enhanced percutaneous absorption via iontophoresis. I. Evaluation of an in vitro system and transport of model compounds
6. A test for the concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis
7. Local anesthesia of the ear by iontophoresis
8. Iontophoresis in dermatology
9. Control of blood glucose levels in alloxandiabetic rabbits by iontophoresis of insulin
10. Facilitated transdermal transport of insulin
11. New frontiers in transdermal drug delivery, Academy of Pharmaceutical Science and Technology of Japan
12. Iontophoretic devices for drug delivery
13. Experimental iontophoresis: Studies with radioisotopes
14. Increased penetration of nonelectrolytes into mouse skin during iontophoretic water transport (iontohydrokinesis)
15. Iontophoretic assistance of 5-iodo-2'-deoxyuridine penetration into neonatal mouse skin and effects on DNA synthesis
16. Movement of charged molecules. The electrical properties of skin
17. Transdermal modulated delivery of polypeptides: Effect of DC pulse wave-form on enhancement
18. Electrochemistry and electrometallurgy
19. Über die Erregung von Elektrizität und Wärme in Elektrolyten
20. Physical principles and formalisms of electrical excitability
21. Ionic mass transport through a homogeneous membrane in the presence of a uniform electric field
22. Electrophoresis of particles in suspension
23. Electrophoresis and other electrokinetic phenomena
24. Potential impedance and rectification in membranes
25. The constant field approximation: Numerical evaluation for monovalent ions migrating across a homogenous membrane
26. The mechanism of iontophoretic transport
27. Electrical properties of the epidermal stratum corneum
28. Electrical characteristics of the skin: The impedance of the surface sheath and deep tissues
29. Experiments on electrical resistance of the human epidermis
30. Interpretation of skin impedance measurements
31. Skin impedance and phase angle as a function of frequency and current
32. A method for the investigation of the impedance of the human body to an alternating current
33. Electrical impedance of the human body
34. A new method of measuring the electrical skin resistance and its clinical application
35. Dispersion and correlation of the parameters for skin impedance
36. Skin impedance and moisturization
37. Skin resistance during square-wave electrical pulses of 1 to 10 mA
38. Drug permeation through human skin: Theory and in vitro experimental methods
39. Drug permeation through human skin. II. Permeability of ionizable compounds
40. A new device in the treatment of hyperhidrosis by iontophoresis
41. Skin reactions. IX. The electrophoretic demonstration of the patent pores of the living human skin; its relation to the charge of the skin
42. Mechanism of eccrine anhidrosis
43. Iontophoresis: Mechanism of action studied by potentiometry and X-ray fluorescence
44. 131 iontophoresis
45. Pathways of ionic flow through human skin in vivo
46. Conformational requirements for the potential dependent pore formation of the peptide antibiotics alamethicin, suzukacillin and trichotoxin
47. The permeability of mammalian skin to ions
48. Iontophoresis studies with a radioactive tracer
49. Iontophoretic medication in ophthalmology
50. Sulfadiazine iontophoresis in pyocyaneous infection of rabbit cornea
51. Iontophoretic induction of atropine and scopolamine into the rabbit eye
52. Iontophoresis of fluorescein into the posterior segment of the rabbit eye
53. Transscleral iontophoresis of cefazolin, ticarcillin and gentamicin in the rabbit
54. Transscleral iontophoresis of gentamicin in monkeys
55. Induction of ocular herpes simplex virus shedding by iontophoresis of epinephrine into rabbit cornea
56. Kinetics of ocular herpes simplex virus shedding induced by epinephrine iontophoresis
57. Herpes simplex virus recovery in neural tissues after ocular HSV shedding induced by epinephrine iontophoresis to the rabbit cornea
58. HSV-1 shedding by iontophoresis of 6-hydroxydopamine followed by topical epinephrine, Invest
59. HSV-1 quantitation from rabbit neural tissues after epinephrine induced reactivation
60. Iontophoresis of epinephrine isomers to rabbit eyes induced HSV-1 ocular shedding
61. Antibiotic iontophoresis in the treatment of ear chondritis
62. Maxillofacial prosthetics and iontophoresis in management of burned ears
63. Anesthesia of the tympanic membrane by iontophoresis
64. Anesthesia of the human tympanic membrane by iontophoresis of a local anesthesia
65. Anesthesia of the tympanic membrane using iontophoresis
66. Modified technique of iontophoresis anesthesia for myringotomy in children
67. Anesthesia of the ear by iontophoresis of lidocaine
68. Reduction of sensitivity by electrophoresis
69. A comparative evaluation of topical application and iontophoresis of sodium fluoride for desensitization of hypersensitive dentin
70. Iontophoresis for surface local anesthesia
71. Fluoride uptake by root dentin after immersion in 2% NaF solution with iontophoresis
72. Practical considerations in iontophoresis of fluoride for desensitizing dentin
73. Effects on pulp and dentin of iontophoresis of sodium fluoride on exposed roots in dogs
74. Iontophoretic application of fluoride by tray techniques for desensitization of multiple teeth
75. Effectiveness of sodium fluoride on tooth hypersensitivity with and without iontophoresis
76. Fluoride levels in dentin after iontophoresis of 2% NaI
77. The effectiveness of iontophoresis in reducing dentin hypersensitivity
78. Percutaneous iontophoresis of prednisolone—A pharmacokinetic study
79. New iontophoretic transdermal administration of the beta blocker metoprolol
80. Citrate iontophoresis in rheumatoid arthritis of the hands
81. Acetic acid iontophoresis for calcium deposits
82. Effect of drugs on the sweat glands by cataphoresis, and an effective method for suppression of local sweating. Observation on the effect of diaphoretics and adiaphoretics
83. Experimental miliaria in man 1 Production of sweat retention anhidrosis and vesicles by means of iontophoresis
84. The treatment of hyperhidrosis of hands and feet with constant current
85. Experimental milaria iontophoresis with salt solutions
86. Simple device for the treatment of hyperhidrosis by iontophoresis
87. Eccrine anhidrosis due to glutaraldehyde, formaldehyde and iontophoresis
88. Treatment of idiopathic hyperhidrosis with iontophoresis of tap water and poldine methosulfate
89. Transcutaneous inhibition of sweat gland function by atropine
90. The treatment of idiopathic hyperhidrosis by glycopyrronium bromide and tap water iontophoresis
91. Poldine iontophoresis in the treatment of plantar and palmar hyperhidrosis
92. Tap water iontophoresis in palmoplantar hyperhidrosis
93. Mechanism of action of iontophoresis in the treatment of palmar hyperhidrosis
94. An iontophoresis unit for the treatment of hyperhidrosis
95. Treatment of excess sweating of the palms by iontophoresis
96. Treatment of hyperhidrosis by tap water iontophoresis
97. Efficacy of the Drionic unit in the treatment of hyperhidrosis
98. A new device for the treatment of hyperhidrosis by iontophoresis
99. Treatment of hyperhidrosis
100. Tapwater iontophoresis in the treatment of hyperhidrosis
101. Electrolyte abnormalities of sweat in fibrocystic diseases of the pancreas
102. Insulin iontophoresis in cystic fibrosis
103. Cystic fibrosis of the pancreas: A study of sweat electrolyte levels in 36 families using pilocarpine iontophoresis
104. Cystic fibrosis — An improved diagnostic method using constant current iontophoresis
105. Iontophoretic sweat test for cystic fibrosis: Technical details
106. Development of a screening system for cystic fibrosis
107. Pilocarpine iontophoresis—Practical aspects
108. Some observations on sweat test by pilocarpine iontophoresis
109. Comparative study: Comparing three methods of performing sweat test to diagnose cystic fibrosis
110. The use of hyaluronidase by iontophoresis in the treatment of generalized scleroderma
111. Use of hyaluronidase by iontophoresis in treatment of lymphedema
112. Treatment of hay fever co-seasonally by electrophoresis of active constituents of ragweed extract
113. Skin reactions: Preseasonal treatment of hay fever by electrophoresis of ragweed extract into the skin, preliminary report
114. Electrophoretic skin studies I Reaction to common grasses
115. The influence of the electric current on the absorption of drugs
116. Fungous infections of hand and feet treated by copper iontophoresis
117. Treatment of epidermophytia on the extremities with iontophoresis of copper
118. Treatment by ion transfer (iontophoresis)
119. Copper iontophoresis in male contraception
120. Penetration of surface tissues with copper by iontophoresis
121. Zinc iontophoresis to treat ischemic skin ulcers
122. The use of magnesium sulfate iontophoresis in the treatment of deltoid bursitis
123. Calcium iontophoresis in suspected myopathy
124. Iodine iontophoresis in reducing scar tissue
125. Cataphoresis in dermabrasion tattooing
126. Experience with anode silver in the treatment of osteomyelitis
127. Silver iontophoresis in chronic osteomyelitis
128. Histamine iontophoresis in rheumatic and peripheral circulatory disturbances
129. Histamine iontophoresis in rheumatic conditions and deficiencies of peripheral circulation
130. Mechanisms of histamine iontophoresis from aqueous media
131. Local vascular effects of histamine iontophoresis and of direct current
132. Histamine iontophoresis to prevent tissue necrosis following Levarterenol extravasation
133. Physiologic and clinical basis for histamine by ion transfer
134. Histamine iontophoresis in the therapy of multiple sclerosis
135. Changes in efferent circulation of tubed pedicles and in the transplantability of large composite grafts produced by histamine iontophoresis
136. Arterialized capillary sampling using histamine iontophoresis
137. The iontophoresis of acetyl-beta-methylcholine chloride in the treatment of chronic arthritis and peripheral vascular diseases
138. Physiologic effects of acetyl-beta-methyl-choline chloride by iontophoresis
139. Iontophoresis of varicose ulcers
140. Treatment of arthritis with acetyl-beta-methyl-choline chloride
141. Use of acetyl-beta-methylcholine chloride iontophoresis in non arterial peripheral vascular disease
142. Evaluation of the local vasodilator effects of mecholyl by iontophoresis
143. Iontophoresis with acetyl-beta-methylcholine and blood flow through the hand at low environmental temperatures
144. Treatment of post herpetic neuralgia
145. Defining a practical solution for iontophoretic local anesthesia of skin
146. Lidocaine anesthesia: Comparison of iontophoresis, injection and swabbing
147. Mini set for iontophoresis for topical analgesia before injection
148. Iontophoresis: Clinical research in musculoskeletal inflammatory conditions
149. Introduction of antiinflammatory drugs by iontophoresis: Double blind study
150. The effect of iontophoresis and vehicle pH on the in vitro permeation of lignocaine through human stratum corneum
151. The treatment of Peyronie's disease by iontophoresis of C21 esterified glucocorticoids
152. The quantity and distribution of radiolabelled dexamethasone delivered to tissue by iontophoresis
153. Is cortisone iontophoresis possible?
154. Iontophoretic injection techniques
155. Responses of blood vessels to various amines applied by microiontophoresis
156. Micro-iontophoretic studies on cortical neurons
157. Penicillin iontophoresis in neocortex of cat: Effects on the spontaneous and induced activity of single neurons
158. Extracellular and intracellular recording during microiontophoresis: An appraisal (proceedings)
159. A simple inexpensive circuit to add balance to microiontophoresis apparatus,
160. A technique for microiontophoretic study of single neurons in a freely moving rat
161. Direct effects of androgens on lateral hypothalamic neuronal activity in the male rat. I. A microiontophoretic study
162. A technique for microiontophoretic study of single neurons in the behaving monkey
163. Iontophoretic application of antiviral chemotherapeutic agents
164. Iontophoretic application of Ara-AMP into adult mouse skin
165. Iontophoretic application of adenosine arabinoside monophosphate to herpes simplex virus type 1 infected hairless mouse skin
166. Iontophoretic application of adenosine arabinoside monophosphate for the treatment of herpes simplex virus type 2 skin infections in hairless mice
167. Iontophoretic application of idoxuridine for recurrent herpes labialis: Report of preliminary clinical findings
168. Iontophoresis and herpes labialis
169. Iontophoretic treatment of oral herpes
170. Iontophoresis: A method of antibiotic administration in the burn patient
171. Sodium salicylate iontophoresis in the treatment of plantar warts (a case report)
172. Observation of effect of iontophoresis of traditional Chinese drug in female infertility
173. Treatment of chronic pain syndromes with iontophoresis of vinca alkaloids to the skin of patients
174. Treatment of vitiligo with 1% solution of the sodium salt of meladine using the iontophoretic technique
175. Antibiotic iontophoresis in the treatment of ear chondritis
176. The potential use of iontophoresis in the treatment of skin disorders
177. Iontophoretic delivery of propranolol across excised rabbit, pig and human skins
178. Transdermal delivery of propranolol via iontophoresis
179. Examination of iontophoretic transport of ionic drugs across skin. I. Baseline studies with four electrode systems
180. Transdermal delivery of oxycodone. I. Animal models, passive diffusion and facilitated transport with iontophoresis
181. Transdermal delivery of oxycodone. II. Enhancement mechanisms with iontophoresis
182. Ophthalmic delivery of peptides and proteins
183. Peptides and protein drug delivery: Opportunities and challenges
184. Nonparenteral administration of peptide and protein drugs
185. Transdermal iontophoretic delivery of insulin for blood glucose control in diabetic rabbits
186. Iontophoresis and promoted drug absorption
187. Potential novel methods for insulin administration: Iontophoresis
188. Transdermal iontophoretic delivery of therapeutic peptides/proteins: (I) Insulin
189. Electro-osmotic transdermal drug delivery
190. Comparison between the iontophoretic and passive transport of thyrotropin releasing hormone across excised nude mouse skin
191. Conductivity of drugs used for iontophoresis
192. Influence of some physical chemical factors on iontophoresis using radio isotopes
193. Quantification of angiotensin iontophoresis
194. 22Na) ions in the guinea pig
195. Noninvasive delivery of a novel inotropic catecholamine. Iontophoretic versus intravenous infusion in dogs
196. Treatment of hyperhidrosis by a battery operated iontophoretic device
197. Iontophoretic application of drugs
198. Electrophoretically controlled dermal or transdermal application systems with electronic indicators
199. Answer to question on iontophoretic delivery of drugs