1-Substituted 7-[3-[(Ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids. New Quantitative Structure-Activity Relationships at N1 for the Quinolone Antibacterials

Journal of Medicinal Chemistry

Volumn 31, Issue 5, 1988, Pages 991-1001

  Domagala, John M ^a   Heifetz, Carl L ^a   Hutt, Marland P ^a   Mich, Thomas F ^a   Nichols, Jeffry B ^a   Solomon, Marjorie ^a   Worth, Donald F ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 7 [3 (ETHYLAMINOMETHYL) 1 PYRROLIDINYL] 6,8 DIFLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; AMIFLOXACIN; CARBOXYLIC ACID DERIVATIVE; CIPROFLOXACIN; DIFLOXACIN; FLEROXACIN; NORFLOXACIN;

CELL CULTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

ANIMAL; ANTI-INFECTIVE AGENTS; BACTERIA; CARBOXYLIC ACIDS; CHEMISTRY; DNA TOPOISOMERASES, TYPE II; MICE; MICROBIAL SENSITIVITY TESTS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023885198     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00400a017     Document Type: Article

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