In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

Cell

Volumn 52, Issue 6, 1988, Pages 831-841

  Uematsu, Yasushi ^a   Ryser, Stefan ^a,b   Dembić, Zlatko ^a,b   Borgulya, Peter ^a   Krimpenfort, Paul ^c   Berns, Anton ^c   von Boehmer, Harald ^a   Steinmetz, Michael ^a,b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN;

ANIMAL EXPERIMENT; CONTROLLED STUDY; MOUSE; NONHUMAN; TRANSGENIC ANIMAL;

ANIMAL; BASE SEQUENCE; CELL MEMBRANE; CELLS, CULTURED; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GENE EXPRESSION REGULATION; GENES, STRUCTURAL; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC;

EID: 0023882920     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(88)90425-4     Document Type: Article

References (51)

1. Structure. function and serology of the T-cell antigen receptor complex
2. The T-cell antigen receptor gamma gene: rearrangement and cell lineages
3. Murine T-cell receptor mutants with deletions of β-chain variable region genes
4. Expression of a munne polyclonal T-cell receptor marker correlates with the use of specific members of the Vβ8 gene segment subfamily
5. Rearrangement of T-cell receptor β-chain genes during T-cell development
6. Ontogeny of T-cell receptor gene expression
7. Somatic recombination in a murine T cell receptor gene
8. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation
9. T-cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments
10. Tandem linkage and unusual RNA splicing of the T-cell receptor β-chain variable-region genes
11. Mapping of the gene encoding the a chain of the T-cell receptor close to the Np-2 locus on mouse chromosome 14
12. Transfer of specificity by murine a and β T-cell receptor gene
13. Correlations between T-cell specificity and the structure of the antigen receptors
14. Lambda replacement vectors carrying polylinker sequences
15. Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes
16. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes
17. Structural studies of murine lymphocyte surface IgD
18. Rearranged β T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between VI, and MHC restriction
19. Rearrangements and expression of T cell antigen receptor and γ genes during thymic development
20. Structure, organization, and somatic rearrangement of T cell gamma genes
21. Differentiation of thymocytes in fetal organ culture
22. Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes
23. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition
24. Genomic organization of the mouse T-cell receptor β chain gene family
25. Identification of a monoclonal antibody specific for a murine T3 peptide
26. Transient rearrangements of the T cell antigen receptor α locus in early thymocytes
27. Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements
28. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ
29. T cell receptor β gene sequences in the circular DNA of thymocyte nuclei direct evidence for intramolecular DNA deletion in V-D-J joining
30. Germline transformation of mice
31. Cytotoxic T cell responses to haptenated cells. I. Primary, secondary and long-term cultures
32. Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gel
33. Rapid transfer of DNA from agarose gel to nylon membrane
34. Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
35. Specific antigen-la activation of transferred human T-cells expressing murine Ti ββ-human T3 receptor complexes
36. The structure, rearrangement and expression of Dβ gene segment of the murine T-cell antigen receptor
37. Ontogeny of the T-cell antigen receptor within the thymus
38. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T-cell antigen receptor
39. Methods in molecular immunology: chromosomal walking in the major histocompatibility complex
40. Gene organization and recombinational hotspots in the murine major histocompatibility complex
41. Transgenic mice with immunoglobulin genes
42. Transgenic mice with μ and κ antiphosphorylcholine antibodies
43. A novel approach for prepaying anti T cell receptor constant region antibodies
44. The same MHC recombinational hotspots are active in crossing-over between wild/wild and wild/inbred mouse
45. Cytolytic T cell clones and hybridomas
46. The role of the T3/antigen receptor complex in T-cell activation
47. H gene segments
48. Regulation of the assembly and expression of variable-region genes
49. Efficient isolation of genes by using antibody probes