Preparation and characterization of monoclonal antibodies directed to the tumor-associated o-linked sialosyl-2→6α-N-Acetylgalactosaminyl (Sialosyl-Tn) Epitope

Cancer Research

Volumn 48, Issue 8, 1988, Pages 2214-2220

  Kjeldsen, Thomas ^a   Clausen, Henrik ^a   Hirohashi, Setsuo ^a   Ogawa, Tomoya ^b   Iijima, Hiroyuki ^b   Hakomori, Sen itiroh ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ADENOCARCINOMA; HISTOCHEMISTRY; HISTOLOGY; HUMAN; HUMAN CELL;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; DISACCHARIDES; EPITOPES; MICE; MICE, INBRED BALB C; MONOSACCHARIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR MARKERS, BIOLOGICAL;

EID: 0023880015     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hakomori, S. Blood group glycolipid antigens and their modifications as human cancer antigens (Philip Levine Award Lecture). Am. J. Clin. Path., 82:635-648, 1984.
2. Hakomori, S. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspective. Cancer Res., 45: 2405–2414, 1985.
3. Dahr, W., Uhlenbruck, G., Gunson, H. H., and Hart, M. V. D. Molecular basis of Tn-polyagglutinability. Vox Sang., 29: 36–50, 1975.
4. Springer, G. F., Desai, P. R., and Bawatwala, I. Blood group MN specific substances and precursors in normal and malignant human breast tissue. Naturwissenschaften, 61:457-458, 1974.
5. Hirohashi, S., Clausen, H., Yamada, T., Shimosata, Y., and Hakomori, S. Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-Lu-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigen. Proc. Natl. Acad. Sci. USA, 82:7039-7043, 1985.
6. Schachter, H., McGuire, E. Y., and Roseman, S. Sialic acids XIII: a uridine diphosphate D-galactose:mucin galactosyl-transferase from porcine submaxillary gland. J. Biol. Chem., 246:5321-5328, 1971.
7. Korosaka, A., Nakayima, H., Fuwakoshi, I., Matsuyama, M., Nagayo, T., and Yamashiwa, I. Structures of major oligosaccharides from a human rectal adenocarcinoma glycoprotein. J. Biol. Chem., 285: 11594–11598, 1983.
8. Colcher, D., Horan Hand, P., Nuti, M., and Schlom, J. A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc. Natl. Acad. Sci. USA, 78:3199-3203, 1981.
9. Nuti, M., Teramoto, Y. A., Mariani-Constantini, R., Hand, P. H., Colcher, D., and Schlom, J. A monoclonal antibody (B72.3) defines patterns of a novel tumor-associated antigen in human mammary carcinoma cell populations. J. Inst. Cancer, 29:539-545, 1982.
10. Thor, A., Ohuchi, W., Szpak, C. A., Johnston, W. W., and Schlom, J. Distribution of oncofectal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res., 46: 3118-3124,1986.
11. Johnson, V. G., Schlom, J., Paterson, A. J., Bennett, J., Magnani, J. H., and Colcher, D. Analysis of human tumor-associated glycoproteins (TAG-72) identified by monoclonal antibody B72.3. Cancer Res., 46:850-857,1986.
12. Kurosawa, A., Fukui, S., Kitagawa, H., Nakeda, H., Namata, Y., Fumakoshi, I., Kawasashi, T., and Yamashiwa, I. Mucin-carbohydrate directed mono-clonal antibody. FEBS Lett., 215:137-139, 1987.
13. Springer, G. F., Desai, P. R., Robinson, M. K., Tegtmeyer, H., and Scanlon, E. F. The fundamental and diagnostic role of T and Tn antigens in breast carcinomas at earliest histologic stage and throughout. In: T. Dao, A. Brodie, and C. Ip (eds.), Tumor Markers and Their Significance in the Management of Breast Cancer, pp. 47–70. New York: A. R. Liss, 1986.
14. Tettamanti, G., and Pigman, W. Isolation and characterization of glycoproteins from ovine submaxillary mucin: purification and characterization of bovine and ovine submaxillary mucins. Arch. Biochem. Biophys., 124: 45–50, 1968.
15. Pigman, W., and Gottschalk, A. Submaxillary gland glycoproteins. In: A. Gottschalk (ed.), Glycoproteins, Vol. 5, pp. 434–445. New York: Elsevier, 1966.
16. Tsuji, T., and Osawa, T. Carbohydrate structures of bovine submaxillary mucin. Carbohydr. Res., 151:391-402,1986.
17. Clausen, H., Levery, S. B., Nudelman, E., Stroud, M., Parker, J., White, T., and Hakomori, S. Isolation and characterization of blood group A-associated type 3 chain glycosphingolipids: galactosyl-A and its sialyl derivative. In: Proc. IXth Intl. Symp. on Glycoconjugates, p. F49. Tourcoing, France: Lerouge, 1987.
18. Springer, G. F. T and Tn, general carcinoma autoantigens. Science (Wash. DC), 224:1198-1206,1984.
19. Nakada, H., Kitagawa, H., Kurosaka, A., Fukui, F., Numata, Y., Funakoshi, I. Kawasaki, T., and Yamashima, I. Monoclonal Antibodies recognizing mucin-type glycoproteins. In: Proc. IXth Intl. Symp. on Glycoconjugates, p. F49. Tourcoing, France: Lerouge, 1987.