Enhancement of the cytotoxicity of crystal violet against Trypanosoma cruzi in the blood by ascorbate

Molecular and Biochemical Parasitology

Volumn 27, Issue 2-3, 1988, Pages 241-247

  Docampo, Roberto ^a   Moreno, Silvia N J ^a   Cruz, Fernando S ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Ascorbyl radical; Crystal violet; Hydrogen peroxide; Superoxide anion; Trypanosoma cruzi

Indexed keywords

ASCORBIC ACID; CRYSTAL VIOLET;

BLOOD TRANSFUSION; CYTOTOXICITY; HUMAN CELL; PREVENTION; PROTOZOON; TRYPANOSOMA CRUZI;

ANIMAL; ASCORBIC ACID; BLOOD TRANSFUSION; CHAGAS DISEASE; DRUG SYNERGISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; GENTIAN VIOLET; MICE; OXIDATION-REDUCTION; OXYGEN; PHOTOCHEMISTRY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRYPANOSOMA CRUZI;

EID: 0023874496     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(88)90043-6     Document Type: Article

References (20)

1. Recent developments in the field of Chagas' disease
2. Chagas' disease and blood transfusion
3. Chagas' disease and blood transfusion
4. Ação de corantes trifenil-metanicos sobre o Trypanosoma cruzi ‘in vitro’
5. O problema da transmissão da doença de Chagas por transfusão de sangue
6. Estudo sobre a eficácia da violeta de genciana na profilaxia da transmissão da doença de Chagas em bancos de sangue: investigação em voluntário, receptor de sangue de caso agudo, ao qual foi adicionado o corante
7. Biochemical toxicology of antiparasitic compounds used in the chemotherapy and chemoprophylaxis of American trypanosomiasis (Chagas' disease)
8. Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet)
9. Photosensitization by the trypanocidal agent crystal violet
10. Evaluation of the toxicity of 3-allyl-β-lapachone against Trypanosoma cruzi bloodstream forms
11. Assay of in situ radicals by electron spin resonance
12. Interaction of crystal violet with nucleic acids
13. Effects of ascorbate on methemoglobin reduction in intact red cells
14. Spin trapping of superoxide
15. Production of hydroxyl radical by decomposition of superoxide spin trapped adducts
16. Chemistry of ascorbic acid
17. Oxidation of ascorbic acid with superoxide anion generated by xanthine-xanthine oxidase system
18. Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi
19. Prooxidant and antioxidant effects of ascorbate on photosensitized peroxidation of lipids in erythrocyte membranes