Effects of U-71,184 and Several Other CC-1065 Analogues on Cell Survival and Cell Cycle of Chinese Hamster Ovary Cells

Cancer Research

Volumn 48, Issue 1, 1988, Pages 109-116

  Adams, Earl G ^a   Badiner, Gloria J ^a   Bhuyan, Bijoy K ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RACHELMYCIN; RACHELMYCIN DERIVATIVE; U 71184;

ANIMAL CELL; CELL CULTURE; CELL CYCLE; CHO CELL; CYTOTOXICITY; DRUG THERAPY; HAMSTER; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HAMSTERS; INDOLES; LEUCOMYCINS; PROTEINS; RNA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023874486     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hanka, L. J., Dietz, A., Gerpheide, S. A., Kuentzel, S. L., and Martin, D. G. CC-1065 (NSC-298223), a new antitumor antibiotic. J. Antibiot. (Tokyo), 31: 1211–1217, 1978.
2. Martin, D. G., Biles, C., Gerpheide, S. A., Hanka, L. J., Krueger, W. C., McGovren, J. P., Mizsak, S. A., Neil, G. L., Stewart, J. C., and Visser, J. CC-1065 (NSC-298223), a potent new antitumor agent—improved production and isolation, characterization, and antitumor activity. J. Antibiot (Tokyo), 34: 1119-1125,1981.
3. Chidester, C. G., Krueger, W. C., Mizsak, S. A., Duchamp, D. J., and Martin, D. G. The structure of CC-1065, a potent antitumor agent and its binding to DNA. J. Am. Chem. Soc., 103:7629, 1981.
4. Neil, G. L., Clarke, G. L., and McGovren, J. P. Antitumor activity and acute toxicity of CC-1065 (NSC-298223) in the mouse. Proc. Am. Assoc. Cancer Res., 22:244,1981.
5. Bhuyan, B. K., Newell, K. A., Crampton, S. L., and Von Hoff, D. D. CC-1065 (NSC-298223), a most potent antitumor agent kinetics of inhibition of growth, DNA synthesis, and cell survival Cancer Res., 42: 3532–3537, 1982.
6. Li, L. H., Swenson, D. H., Schpok, S. L. F., Kuentzel S. L., Dayton, B. D., and Krueger, W. C. CC-1065 (NSC-298223), a novel antitumor agent that interacts strongly with double-stranded DNA. Cancer Res., 42: 999–1004, 1982.
7. Swenson, D. H., Li, L. H., Hurley, L. H., Rokem, J. J., Petzold, G. L., Dayton, B. D., Wallace, T. L., Lin, A. H., and Krueger, W. C. Mechanism of interaction of CC-1065 (NSC-298223) with DNA. Cancer Res., 42:2821-2828,1982.
8. Reynolds, V. L., McGovren, J. P., and Hurley, L. H. The chemistry, mechanism and biological properties of CC-1065, a potent antitumor antibiotic. J. Antibiot (Tokyo), 39:319-334,1986.
9. McGovren, J. P., Clarke, G. L., Pratt, E. A., and DeKoning, T. F. Preliminary toxicity studies with the DNA-binding antibiotic CC-1065. J. Antibiot (Tokyo), 37:63-70,1984.
10. Wierenga, W. Synthesis of the left-hand segment of the antitumor agent CC-1065. J. Am. Chem. Soc., 103:5621-5623, 1981.
11. Warpehoski, M. A., Kelly, R. C., McGovren, J. P., and Wierenga, W. IV-2-substituted tetrahydro-4-oxocyclopropa[c)pyrrolo-(3,2-e]indoles: novel anticancer agents modeled on CC-1065. Proc. Am. Assoc. Cancer Res., 26:870, 1985.
12. Petzold, G. L., Krueger, W. C., Swenson, D.H., Wallace, T. L., Prairie, M. D., and Li L. H. Biochemical and cytotoxic effects of CC-1065 analogs. Proc. Am. Assoc. Cancer Res., 26:225,1985.
13. Wierenga, W., Bhuyan, B. K., Kelly, R. C., Krueger, W. C., Li, L. H., McGovren, J. P., Swenson, D. H., and Warpehoski, M. A. Antitumor activity and biochemistry of novel analogs of the antibiotic CC-1065. Adv. Enzyme Regul., 25:141-155,1986.
14. Bhuyan, B. K., Badiner, G. J., and Adams, E. G. Inhibition of nucleic acid synthesis and of survival and progression in CHO cells by U-71,184. Proc. Am. Assoc. Cancer Res.,
15. Bhuyan, B. K., Badiner, O. J., and Adams, E. G. Cell-kill kinetics and cell cycle profile of CC-1065 analogs. Proc. Am. Assoc. Cancer Res., 26: 226, 1985.
16. Bhuyan, B. K., Crampton, S. L., and Adams, E. G. Cell cycle effects of CC-1065. Cancer Res., 43:4227-4232,1983.
17. Adams, E. G., Crampton, S. L., and Bhuyan, B. K. Effect of 7-con-O-methylnogarol on DNA synthesis, survival, and cell cycle progression of Chinese hamster ovary cells. Cancer Res., 41:4981-4987,1981.
18. Crissman, H. A., and Steinkamp, J. A. Rapid, one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry. Cytometry, 3:84-90, 1982.
19. Cohen, L. S., and Studzinski, G. P. Correlation between cell enlargement and nucleic acid and protein content of HeLa cells in unbalanced growth produced by inhibitors of DNA synthesis. J. Cell. Physiol., 69: 331–340, 1967.
20. Harbach, P. R., Mazuek, J. H., Zimmer, D. M., Trzos, R. J., and Bhuyan, B. K. Genotoxicity of CC-1065 (NSC-298223) and its analogs. Proc. Am. Assoc. Cancer Res., 24:95,1983.
21. Darzynkiewicz, Z., Evenson, D. P., Staiano-Coico, L., Sharpless, T., Melamed, M. R. Correlation between cell cycle duration and RNA content. J. CeU. Physiol., 100:425-438,1979.
22. Traganos, F., Staiano-Coico, L., Darzynkiewicz, Z., and Melamed, M. R. Effects of acclacinomycin on cell survival and cell cycle progression of cultured mammalian cells. Cancer Res., 41:2728-2733, 1981.
23. Moy, B. C., Prairie, M. D., Krueger, W. C., and Bhuyan, B. K. Molecular aspects of CC-1065 interaction with chromatin. J. Cell Biol., 103:40a, 1986.
24. Warpehosld, M. A., Kelly, R. D., and Krueger, W. C. Comparison of the antitumor activity and DNA binding of U-71,184 analogs. Proc. Am. Assoc. Cancer Res., 27:252, 1986.