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Volumn 29, Issue 12, 1988, Pages 1367-1370

Synthetic efforts directed towards the taxol skeleton. The saturated C-ring approach

Author keywords

[No Author keywords available]

Indexed keywords

TAXOL DERIVATIVE;

EID: 0023872890     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)80298-1     Document Type: Article
Times cited : (46)

References (18)
  • 4
    • 37049068163 scopus 로고
    • J. Chem. Soc.
    • Several recent synthetic approaches to the taxane skeleton may be found in the following references, Perkin Trans. 1
    • (1986) J. Chem. Soc. , pp. 1303
    • Brown1    Jenkins2
  • 8
    • 0000332134 scopus 로고
    • A more complete list of references regarding synthetic entries into the taxane natural products can be found in these references.
    • (1987) Tetrahedron Lett. , pp. 2221
    • Wender1    Snapper2
  • 9
    • 84918486646 scopus 로고    scopus 로고
    • All new compounds gave spectral data consistent with the assigned structures.
  • 10
    • 84918486645 scopus 로고    scopus 로고
    • 3: 332.2351, found: 332.2354. [[Truncated]]
  • 11
    • 84918486644 scopus 로고    scopus 로고
    • 81Br).
  • 12
    • 84918486643 scopus 로고    scopus 로고
    • Bromodiene 6 was prepared in three steps from 1,1-dibromo-2,2,3,3-tetramethylcyclopropane. Thermally induced dehydrohalogenative ring opening yields 3-bromo-2,4-dimethyl-1,3-pentadiene (84%). Metalation (t-buLi, −78°C) followed by an ethylene oxide quench gave a homoallylic alcohol (55%) which was converted to bromide 6 by tosylation followed by refluxing in acetone/NaBr (62%).
  • 14
    • 84918486642 scopus 로고    scopus 로고
    • 2: 362.1738, found: 362.1722.
  • 15
    • 84918486641 scopus 로고    scopus 로고
    • 28 [[Truncated]]
  • 16
    • 84918486640 scopus 로고    scopus 로고
    • Yields for this reaction were somewhat erratic, possibly due to the long reaction time and large excess of Lewis acid needed.
  • 17
    • 0001387396 scopus 로고
    • The application of intramolecular saturation transfer NMR spectroscopy to conformational analysis. The effect of methyl substituents on the barrier height and conformational isomer population of the tricyclo[9.3.1.03,8]pentadecane ring system.
    • (1984) Tetrahedron Letters , pp. 2451
    • Shea1    Gilman2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.