Enantiomers of cyclophosphamide and iphosphamide

Biochemical Pharmacology

Volumn 37, Issue 1, 1988, Pages 145-148

  Farmer, P B ^a  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; IFOSFAMIDE;

ENANTIOMER; PRIORITY JOURNAL;

ANIMAL; CYCLOPHOSPHAMIDE; HUMAN; IFOSFAMIDE; STEREOISOMERISM;

EID: 0023870887     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(88)90767-8     Document Type: Article

References (23)

1. The synthesis of enantiomeric cyclophosphamides
2. The use of deuterated analogs in qualitative and quantitative investigations of the metabolism of cyclo-phosphamide (NSC-26271)
3. Observations on the differential metabolism and biological activity of the optical isomers of cyclo-phosphamide
4. Comparative metabolism of 2-[bis(2-chloroethyl)-amino]tetrahydro-2H-1,3,2-oxaza-phosphorine-2-oxide (cyclophosphamide) and its enantiomers in humans
5. Cyclophosphamide stereochemistry. I. Synthesis and configurational stability of diastereomeric cyclophosphamide derivatives
6. Determination of enantiomeric homogeneity (optical purity) of cyclo-phosphamide by nuclear resonance spectroscopy
7. Assymmetric synthesis of enantiomeric cyclophosphamides
8. Absolute configuration of the cancerostatic S(−)-cyclo-phosphamide
9. X-ray diffraction study and determination of the absolute configuration of the anti-cancer drug S-(−)-cyclo-phosphamide (Endoxan, Cytoxan, NS -26271)
10. Absolute configuration of (+)-cyclophosphamide. A crystal and molecular structure determination by X-ray diffraction
11. Optical resolution studies of cyclophosphamide
12. Resolution of chiral phosphamides
13. Formation of diastereoisomeric derivatives from the enantiomers of the antitumour agent cyclophosphamide by reaction with 1-phenylethyl alcohol, and their separation by thin-layer chromatography
14. Chromatographic resolutions. XIV. Optical resolution of the racemic anticancer drug ifosfamide and other chiral oxaza-phosphorines
15. The synthesis of the optical isomers of 2-(2-chloroethylamino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide (isophosphamide)
16. Stereospecific synthesis of (R)- and (S)-isophosphamide
17. Synthesis and absolute configuration assignments of enantiomeric forms of ifosphamide, sulfosphamide and trofosphamide
18. Optical resolution of the antitumour agents isophosphamide and triphosphamide by means of dias-tereomeric platinum (II) complexes
19. Absolute configuration of the cancerostatic S-(−)-isophosphamide
20. Stereoselectivity in the metabolism of the enantiomers of cyclophosphamide in mice, rats and rabbits
21. Application of deuterium labelling mass spectrometry in a study of the metabolism of the enantiomers of cyclophosphamide
22. Effects of enantiomeric homogeneity on the in vitro metabolism and in vivo anticancer activity of (+)- and (−)-cyclophosphamide
23. Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in urine