Comparison of the pyrimidine nucleoside phosphorylase activity in human tumors and normal tissues

Experimental Pathology

Volumn 33, Issue 1, 1988, Pages 23-25

  Choong, Y S ^a   Lee, S P ^a   Alley, P A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

5 deoxy 5 fluorouridine; cancer chemotherapy; fluoropyrimidine; gastrointestinal cancer; pyrimidine nucleoside phosphorylase; tumor inhibition

Indexed keywords

FLOXURIDINE;

DIGESTIVE SYSTEM CANCER; HISTOLOGY; HUMAN; HUMAN CELL;

EID: 0023867529     PISSN: 02321513     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0232-1513(88)80050-1     Document Type: Article

References (13)

1. 5′-deoxy-5-fluorouridine: selective toxicity for human tumour cells compared to human bone marrow
2. Metabolism and biological activity of 5′-deoxy-5-fluorouridine, a novel fluoro-pyrimidine
3. Tumour inhibitory effects of a new fluorouracil derivative: 5′-deoxy-5-fluorouridine
4. The degradation of 5′-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues
5. Fluorinated pyrimidines, a new class of tumor inhibitory compounds
6. Mechanisms of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluoridine and 5-fluoro-2′-deoxyuridine
7. Role of uridine phosphorylase for antimour activity of 5′-deoxy-5-fluorouridine
8. Activation of 5′-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors
9. 5′-deoxy-5-fluorouridine — a new orally active anti-tumour agent. Comparative activity with 5-fluorouracil, 2′-deoxy-5-fluorouridine and florofur against transplantable tumour in mice and rats
10. Protein measurements with the folin phenol reagent
11. Comparative studies on the immunosuppressive effect among 5′-deoxy-5-fluorouridine, florofur and 5-fluorouracil
12. Tissue distribution of 5′-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor bearing rats and mice
13. Specificity of pyrimidine nucleoside phosphorolysis of 5′-fluoro-2′-deoxyuridine